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Journals / International Journal of Health Services Research and Policy / 2026 / Volume: 4 Issue: 1

HISTOLOGICAL AND HISTOCHEMICAL EVALUATION OF NORMOTENSIVE AND PREECLAMPTIC PLACENTAS

Gamze Erdogan(Dicle University)0000-0002-5854-8517
Yusuf Nergiz(Dicle University)0000-0002-9988-9385
Elif Ağaçayak(Dicle University)0000-0002-5854-8517
Pages
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Publication Date
2019-04-01
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The level of alkaline phosphatase enzyme in preeclamptic placentas was found to be lower compared to normotensive placenta.

📌 3 Key Takeaways

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Objective & Hypothesis:The placenta plays a role in the pathophysiology of preeclampsia.
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Key Findings & Data:In our study, 10 normotensive and 10 preeclamptic, totally 20 placentas were obtained.Paraffin sections were stained with Hematoxylin-Eosin, Masson trichrome and PAS for histopathological examination.Remaining sections were then stained via Gomori’s method and micrographed under light microscope.
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Conclusion & Impact:The level of alkaline phosphatase enzyme in preeclamptic placentas was found to be lower compared to normotensive placenta.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Placenta · Preeclampsia · Alkaline phosphatase

Abstract

The placenta plays a role in the pathophysiology of preeclampsia. Preeclampsia is more common in multifetal pregnancies than singleton pregnancies. In this study, we aimed to investigate the histopathology of normotensive and preeclamptic placentas and the localization of alkaline phosphatase activity. In our study, 10 normotensive and 10 preeclamptic, totally 20 placentas were obtained.Paraffin sections were stained with Hematoxylin-Eosin, Masson trichrome and PAS for histopathological examination.Remaining sections were then stained via Gomori’s method and micrographed under light microscope. Sections of the control group observed normal histologically structure.The alkaline phosphatase reaction was evident in the inner and outer membranes of the syncytiotrophoblasts. There was a significant increase in the number of syncytial knots, terminal villi and syncytial bridges in the preeclamptic placenta sections. Marked thickening of the trophoblast basal membranes were observed. Alkaline phosphatase reaction in preeclampsia group: The localization of alkaline phosphatase in the inner and outer membranes of the syncytiotrophoblasts was reduced. In placentas of preeclampsia group, a significant increase in syncytial knot, syncytial bridge were observed. The level of alkaline phosphatase enzyme in preeclamptic placentas was found to be lower compared to normotensive placenta.

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Cite This Article

Erdogan, G., Nergiz, Y., Ağaçayak, E. (2019). HISTOLOGICAL AND HISTOCHEMICAL EVALUATION OF NORMOTENSIVE AND PREECLAMPTIC PLACENTAS. International Journal of Health Services Research and Policy, Volume: 4 Issue: 1. https://doi.org/10.23884/ijhsrp.2019.4.1.07

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