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Journals / Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi / 2026 / Volume: 45 Issue: 1

Antiviral Potential of Cistus L. against Infectious Bronchitis Virus and SARS-CoV-2

Cistus L.'nin Enfeksiyöz Bronşitis Virüsü ve SARS-CoV-2'ye Karşı Antiviral Potansiyeli

Feyruz Bozoglan(EGE UNIVERSITY)0000-0003-3868-9109
Ali Ergüç(ONDOKUZ MAYIS UNIVERSITY)0000-0002-9791-4399
Furkan Ozan Çöven(EGE ÜNİVERSİTESİ)0000-0001-7696-3418
Gizem Gungor Erkanli(EGE ÜNİVERSİTESİ)0000-0001-7229-5934
Engin Alp Onen0000-0003-1661-5803
Ahmet C Goren(GEBZE TECHNICAL UNIVERSITY)0000-0002-5470-130X
Ayşe Nalbantsoy(ege ü.)0000-0002-3852-1974
Pages
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Publication Date
2025-03-01
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Increasing incubation time and concentration of C. creticus extract led to increase of antiviral activity against SARS-CoV-2, which means that C. creticus extract had potent antiviral activity.

📌 3 Key Takeaways

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Objective & Hypothesis:Cistus L. (Cistus) is distributed in Türkiye by 5 species including Cistus creticus L. (C. creticus), Cistus monspeliensis L. (C. monspeliensis), Cistus laurifolius L. (C. laurifolius), Cistus parviflorus L. (C. parviflorus) and Cistus salviifolius L. (C. salviifolius).
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Key Findings & Data:In this study, antiviral activity of 5 Cistus extracts were investigated against Infectious bronchitis virus (IBV) using the in ovo antiviral activity assay, which measures both embryo viability and agglutination of chicken red blood cells.
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Conclusion & Impact:Increasing incubation time and concentration of C. creticus extract led to increase of antiviral activity against SARS-CoV-2, which means that C. creticus extract had potent antiviral activity.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Cistus L. · IBV · SARS‑CoV‑2

Abstract

Cistus L. (Cistus) is distributed in Türkiye by 5 species including Cistus creticus L. (C. creticus), Cistus monspeliensis L. (C. monspeliensis), Cistus laurifolius L. (C. laurifolius), Cistus parviflorus L. (C. parviflorus) and Cistus salviifolius L. (C. salviifolius). In this study, antiviral activity of 5 Cistus extracts were investigated against Infectious bronchitis virus (IBV) using the in ovo antiviral activity assay, which measures both embryo viability and agglutination of chicken red blood cells. In further experiments, antiviral potential of C. creticus extract was also examined against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected Vero-E6 cells. In ovo antiviral activity assays displayed that C. parviflorus and C. monspeliensis extracts caused more antiviral activity against IBV-D274 strain than other extracts. Further asssays showed that C. creticus extract led to dose and time dependent antiviral activity against SARS-CoV-2. The results proposed that C. parviflorus and C. monspeliensis extracts might have a potential for the treatment of virus-mediated diseases. Increasing incubation time and concentration of C. creticus extract led to increase of antiviral activity against SARS-CoV-2, which means that C. creticus extract had potent antiviral activity.

Özet

Cistus L. (Cistus), Türkiye'de Cistus creticus L. (C. creticus), Cistus monspeliensis L. (C. monspeliensis), Cistus laurifolius L. (C. laurifolius), Cistus parviflorus L. (C) olmak üzere 5 tür tarafından yayılış göstermektedir. . parviflorus) ve Cistus salviifolius L. (C. salviifolius). Bu çalışmada, 5 Cistus ekstraktının antiviral aktivitesi, hem embriyo canlılığını hem de tavuk kırmızı kan hücrelerinin aglütinasyonunu ölçen in ovo antiviral aktivite tahlili kullanılarak Enfeksiyöz bronşitis virüsüne (IBV) karşı araştırıldı. Daha sonraki deneylerde, C. creticus ekstraktının antiviral potansiyeli, şiddetli akut solunum sendromu koronavirüs 2 (SARS-CoV-2) ile enfekte Vero-E6 hücrelerine karşı da incelenmiştir. İn ovo antiviral aktivite analizleri, C. parviflorus ve C. monspeliensis ekstraktlarının IBV-D274 suşuna karşı diğer ekstraktlara göre daha fazla antiviral aktiviteye neden olduğunu göstermiştir. Daha ileri analizler, C. creticus ekstraktının SARS-CoV-2'ye karşı doza ve zamana bağlı antiviral aktiviteye yol açtığını gösterdi. Sonuçlar, C. parviflorus ve C. monspeliensis ekstraktlarının virüs kaynaklı hastalıkların tedavisinde potansiyele sahip olabileceğini öne sürdü. Artan inkübasyon süresi ve C. creticus ekstraktının konsantrasyonu SARS-CoV-2'ye karşı antiviral aktivitenin artmasına yol açtı, bu da C. creticus ekstraktının güçlü antiviral aktiviteye sahip olduğu anlamına geliyor.

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Cite This Article

Bozoglan, F., Ergüç, A., Çöven, F. O., Erkanli, G. G., Onen, E. A., Goren, A. C., Nalbantsoy, A. (2025). Antiviral Potential of Cistus L. against Infectious Bronchitis Virus and SARS-CoV-2. Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi, Volume: 45 Issue: 1. https://doi.org/10.52794/hujpharm.1525333

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