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Journals / Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi / 2025 / Volume: 45 Issue: 4

Tranexamic Acid in Dermatology: Exploring Its Antioxidant Activity and Therapeutic Potential for Melasma

Merve Nenni(Çukurova Üniversitesi)0000-0003-3165-1060
Tuğba Tehçi(Adana City Training and Research Hospital, Department of Dermatology)0000-0002-8588-4292
Pages
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Publication Date
2025-12-01
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The 2,2′-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay is a widely accepted and often employed test for quantifying the overall antioxidant capacity of substances.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Melasma, a condition causing uneven brown patches on the forehead, cheeks, and chin, is classified into epidermal, dermal, mixed, and indeterminate types.
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Key Findings & Data:The 2,2′-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay is a widely accepted and often employed test for quantifying the overall antioxidant capacity of substances.
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Conclusion & Impact:After examining the results, it is clear that TXAA exhibits antioxidant activity, although it is less potent than the antioxidant effect of ascorbic acid.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Tranexamic acid · DPPH · Antioxidant

Abstract

Melasma, a condition causing uneven brown patches on the forehead, cheeks, and chin, is classified into epidermal, dermal, mixed, and indeterminate types. Treatment options include tranexamic acid (TXAA), which has been increasingly used recently. The 2,2′-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay is a widely accepted and often employed test for quantifying the overall antioxidant capacity of substances. The DPPH method was used to calculate the antioxidant scavenging percentages of TXAA and ascorbic acid (vitamin C). TXAA showed a DPPH radical scavenging activity of 60.77±0.34% at 50,000 ppm, while ascorbic acid showed a DPPH radical scavenging activity of 95.77±0.59% at 1000 ppm. Ascorbic acid is a known powerful antioxidant. After examining the results, it is clear that TXAA exhibits antioxidant activity, although it is less potent than the antioxidant effect of ascorbic acid.

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Cite This Article

Nenni, M., Tehçi, T. (2025). Tranexamic Acid in Dermatology: Exploring Its Antioxidant Activity and Therapeutic Potential for Melasma. Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi, Volume: 45 Issue: 4. https://doi.org/10.52794/hujpharm.1669708

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