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Journals / Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi / 2026 / Volume: 46 Issue: 2

Alginate–Basil Seed Hydrogel Films for Sustained Topical Delivery of Silver Sulfadiazine

Kailas Krishnat Mali(Adarsh College of Pharmacy, Vita)0000-0002-1789-3592
Vijay Daulatrao Havaldar(Adarsh Institute of Pharmacy, Vita)0009-0006-7092-5609
Pratiksha Dadaso Narute(Adarsh College of Pharmacy, Vita)0009-0001-7489-5551
Niranjan Mahajan(Adarsh College of Pharmacy, Vita)0000-0002-2432-4507
Remeth Jacky Dias(Government College of Pharmacy, Karad)0000-0002-8234-9630
Pages
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Publication Date
2026-06-01
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Overall, SA–BSM hydrogel films show strong potential as wound dressings, offering a stable, biocompatible matrix for sustained SSD delivery.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:This study developed and evaluated silver sulfadiazine (SSD)-loaded hydrogel films based on sodium alginate (SA) and basil seed mucilage (BSM) for controlled topical delivery.
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Key Findings & Data:Films were formulated by varying SA (800–1000 mg) and BSM (50–200 mg) with calcium chloride (CaCl2) (5–15%) as the crosslinker and propylene glycol (15% w/w) as a plasticizer.
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Conclusion & Impact:Overall, SA–BSM hydrogel films show strong potential as wound dressings, offering a stable, biocompatible matrix for sustained SSD delivery.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Sodium alginate · Basil seed mucilage · Hydrogel films

Abstract

This study developed and evaluated silver sulfadiazine (SSD)-loaded hydrogel films based on sodium alginate (SA) and basil seed mucilage (BSM) for controlled topical delivery. Films were formulated by varying SA (800–1000 mg) and BSM (50–200 mg) with calcium chloride (CaCl2) (5–15%) as the crosslinker and propylene glycol (15% w/w) as a plasticizer. The optimized film (900 mg SA, 100 mg BSM, 10% CaCl2, 30 min) was selected for its superior integrity and swelling. Attenuated Total Reflectance–Fourier Transform Infrared Spectroscopy (ATR–FTIR), Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), and X-ray Diffraction (XRD) confirmed SSD compatibility and uniform polymer dispersion. The optimized film exhibited high swelling (~38 g/g), moderate thickness (~609 μm), excellent flexibility (~252 folds), optimum tensile strength (0.454 kg/cm2) and good surface wettability (~48° contact angle), reflecting balanced hydrophilicity and mechanical strength. In vitro release followed Fickian diffusion (Korsmeyer–Peppas n < 0.45), while additional evaluations confirmed appropriate water vapor transmission, microbial barrier properties, and hemocompatibility (< 5% hemolysis), supporting its biocompatibility. Overall, SA–BSM hydrogel films show strong potential as wound dressings, offering a stable, biocompatible matrix for sustained SSD delivery. However, as the study was limited to in vitro evaluations, further in vivo, stability, wound healing, and mechanical studies are warranted.

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Cite This Article

Mali, K. K., Havaldar, V. D., Narute, P. D., Mahajan, N., Dias, R. J. (2026). Alginate–Basil Seed Hydrogel Films for Sustained Topical Delivery of Silver Sulfadiazine. Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi, Volume: 46 Issue: 2. https://doi.org/10.52794/hujpharm.1729518

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