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Journals / Dicle Üniversitesi Veteriner Fakültesi Dergisi / 2020 / Cilt: 13 - Sayı: 1

Distribution of Vascular Endothelial Growth Factor and Receptors in Rat Liver

Sıçan Karaciğerinde Vasküler Endoteliyal Büyüme Faktörü ve Reseptörlerinin Dağılımı

Bayram BAYRAM
Hakan SAĞSÖZ
Pages
56–60
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As a result, the findings also indicate that VEGF and receptors (flt1/fms, flk1/KDR and flt4) played important roles in the physiological changes of rat liver.

📌 3 Key Takeaways

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Objective & Hypothesis:The liver regenerate after various damages is a phenomenon essential for the maintenance of its important functions such as detoxification and metabolism.
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Key Findings & Data:Vascular endothelial growth factor (VEGF) increases microvascular permeability and is a specific mitogen for endothelial cells and is thought to take an important role in angiogenesis.
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Conclusion & Impact:As a result, the findings also indicate that VEGF and receptors (flt1/fms, flk1/KDR and flt4) played important roles in the physiological changes of rat liver.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The liver regenerate after various damages is a phenomenon essential for the maintenance of its important functions such as detoxification and metabolism. The regeneration process is histologically well described. Of particular interest are cytokines and growth factors, which control different phases of liver regeneration. Vascular endothelial growth factor (VEGF) increases microvascular permeability and is a specific mitogen for endothelial cells and is thought to take an important role in angiogenesis. The present study examined VEGF and receptors (flt1/fms, flk1/KDR and flt4) expression immunohistochemically. In this study, ten rats were used. Positive immunoreaction for VEGF and its receptors was determined in the hepatocyte and endothelial and smooth muscle cells of blood vessels in the rat liver. However, the flt1/fms immunoreactivity in hepatocytes around the vena centralis was quite strong compared to VEGF, flk1/KDR and flt4. As a result, the findings also indicate that VEGF and receptors (flt1/fms, flk1/KDR and flt4) played important roles in the physiological changes of rat liver.

Özet

Karaciğerin çeşitli hasarlardan sonra yenilenmesi, metabolizmanın ve detoksifikasyon gibi önemli fonksiyonlarının sürdürülmesi için gerekli bir olaydır. Rejenerasyon olayı histolojik olarak çok iyi bir şekilde tanımlanmıştır. Özellikle ilgi çekici olan, karaciğer rejenerasyonunun farklı fazlarını kontrol eden sitokinler ve büyüme faktörleridir. Vasküler endoteliyal büyüme faktörü (VEGF) mikrovasküler geçirgenliği arttırır ve endoteliyal hücreler için spesifik bir mitojendir ve anjiyogenezde önemli bir rol oynadığı düşünülmektedir. Sunulan çalışmada, VEGF ve reseptörlerin (fltl / fms, flkl / KDR ve flt4) ekspresyonu immünohistokimyasal olarak incelendi. Bu çalışmada 10 adet sıçan kullanıldı. VEGF ve reseptörleri için pozitif immünoreaksiyon, sıçan karaciğerindeki hepatositler ile kan damarlarının endotel ve düz kas hücrelerinde belirlendi. Bununla birlikte, vena sentralis çevresindeki hepatositlerde flt1/fms immünreaktivitesi VEGF, flk1/KDR ve flt4 ile karşılaştırıldığında oldukça güçlü idi. Sonuç olarak, VEGF ve reseptörlerin (flt1/fms, flk1/KDR ve flt4) sıçan karaciğerinin fizyolojik değişikliklerinde önemli roller oynadığını göstermektedir.

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Cite This Article

BAYRAM, B., SAĞSÖZ, H. (2020). Distribution of Vascular Endothelial Growth Factor and Receptors in Rat Liver. Dicle Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 13 - Sayı: 1, 56–60. https://ajindex.com/articles/148866

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