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Journals / Experimental and Applied Medical Science / 2025 / Cilt: 6 Sayı: 4

Appropriateness of Antibiotic Treatment in Lower Respiratory Tract Infections: A Cross-Sectional Study

ALT SOLUNUM YOLU ENFEKSİYONLARINDA ANTİBİYOTİK TEDAVİSİNİN UYGUNLUĞU: KESİTSEL BİR ÇALIŞMA

Yaşar İncekara(KARAMANOĞLU MEHMETBEY UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF PULMONARY DISEASES)0000-0002-1430-1571
Selda Aslan(Gaziantep Şehir Hastanesi)0000-0001-8695-7118
Pages
338–348
Publication Date
2025-12-31
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: According to MAI assessment, overall clinical appropriateness of antibiotic prescribing was high.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: This study aimed to evaluate the appropriateness of antibiotic therapy and discharge prescriptions in patients with lower respiratory tract infections (LRTIs) using the Medication Appropriateness Index (MAI) criteria.
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Key Findings & Data:Methods: A retrospective cross-sectional study was conducted between January 2022 and January 2024 at a tertiary training and research hospital.
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Conclusion & Impact:Conclusion: According to MAI assessment, overall clinical appropriateness of antibiotic prescribing was high.
🔬Design:Araştırma Makalesi
📍Scope:2022 Verileri
⚙️Variables:Alt Solunum Yolu Enfeksiyonu · antibiyotik uygunluğu · İlaç Uygunluk İndeksi

Abstract

Objective: This study aimed to evaluate the appropriateness of antibiotic therapy and discharge prescriptions in patients with lower respiratory tract infections (LRTIs) using the Medication Appropriateness Index (MAI) criteria. Methods: A retrospective cross-sectional study was conducted between January 2022 and January 2024 at a tertiary training and research hospital. A total of 111 patients diagnosed with community-acquired pneumonia, acute/chronic bronchitis, or infectious exacerbations of COPD and asthma were included. Prescriptions were evaluated independently by two physicians based on the ten MAI domains. Results: All prescriptions were fully appropriate regarding indication, effectiveness, dosage, and directions (100%). No clinically significant drug–drug or drug–disease interactions were detected. Unnecessary antibiotic duplication occurred in 4.5% of cases, and cost appropriateness was achieved in 68%. Monotherapy was predominant during hospitalization, while a trend toward narrower-spectrum and more cost-effective regimens was observed at discharge. Conclusion: According to MAI assessment, overall clinical appropriateness of antibiotic prescribing was high. Reducing unnecessary duplication and promoting cost-effective alternatives may further strengthen rational antibiotic use and antimicrobial stewardship practices.

Özet

Amaç: Bu çalışma, alt solunum yolu enfeksiyonu (ASYE) tanısı ile izlenen hastalarda antibiyotik tedavilerinin ve taburculuk reçetelerinin uygunluğunu İlaç Uygunluk İndeksi (Medication Appropriateness Index, MAI) kriterlerine göre değerlendirmeyi amaçlamaktadır. Yöntem: Ocak 2022–Ocak 2024 tarihleri arasında üçüncü basamak bir eğitim ve araştırma hastanesinde retrospektif, kesitsel tasarımda yürütülen çalışmaya, toplum kökenli pnömoni, akut/kronik bronşit, KOAH ve astımın enfeksiyon kaynaklı alevlenmeleri nedeniyle antibiyotik tedavisi alan 111 hasta dahil edildi. Reçetelerin uygunluğu, iki uzman hekim tarafından MAI’nin on değerlendirme alanına göre puanlandı. Bulgular: Tüm reçetelerde antibiyotik endikasyonu, etkililik, dozaj ve talimatların doğruluğu açısından tam uygunluk (%100) saptandı. Klinik olarak anlamlı ilaç–ilaç veya ilaç–hastalık etkileşimi görülmedi. Gereksiz antibiyotik duplikasyonu %4,5 oranında saptandı. Maliyet uygunluğu %68 idi. Yatışta monoterapi oranı yüksek olup, taburculukta daha dar spektrumlu ve maliyet-etkin antibiyotiklere geçiş eğilimi gözlendi. Sonuç: MAI değerlendirmesine göre, antibiyotik reçeteleme sürecinde genel klinik uygunluk yüksek bulunmuştur. Ancak gereksiz duplikasyonun azaltılması ve maliyet-etkin seçeneklerin daha yaygın tercih edilmesi, akılcı antibiyotik kullanımını daha da güçlendirecektir.

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Cite This Article

İncekara, Y., Aslan, S. (2025). Appropriateness of Antibiotic Treatment in Lower Respiratory Tract Infections: A Cross-Sectional Study. Experimental and Applied Medical Science, Cilt: 6 Sayı: 4, 338–348. https://doi.org/10.46871/eams.1812615

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