Journals / Dental and Medical Journal - Review / 2026 / Cilt: 8 Sayı: 1

Photobiomodulation Therapy in Pediatric Dentistry

Çocuk Diş Hekimliğinde Fotobiyomodülasyon Terapisi

Özge Bektaş(HACETTEPE UNIVERSITY, FACULTY OF DENTISTRY)0000-0002-6157-2534
Pages
19–36
Publication Date
2026-05-10
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

When the literature is examined, it is seen that more clinical research is required to expand the effectiveness and usage areas of photobiomodulation therapy in the field of pediatric dentistry.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Photobiomodulation therapy, which is an effective and up-to-date treatment in dentistry, can be beneficial in pediatric dentistry, especially in the treatment of oral diseases, since it is noninvasive and does not cause side effects.
📊
Key Findings & Data:In this review, a literature review was conducted to reach current studies on photobiomodulation therapy with low-intensity laser used in pediatric dentistry, and the biostimulatory effect of low-intensity laser use in clinical practice was mentioned.
💡
Conclusion & Impact:When the literature is examined, it is seen that more clinical research is required to expand the effectiveness and usage areas of photobiomodulation therapy in the field of pediatric dentistry.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:fotobiyomodülasyon terapisi · çocuk diş hekimliği · dental teknoloji

Abstract

Photobiomodulation therapy, which is an effective and up-to-date treatment in dentistry, can be beneficial in pediatric dentistry, especially in the treatment of oral diseases, since it is noninvasive and does not cause side effects. In this review, a literature review was conducted to reach current studies on photobiomodulation therapy with low-intensity laser used in pediatric dentistry, and the biostimulatory effect of low-intensity laser use in clinical practice was mentioned. When the literature is examined, it is seen that more clinical research is required to expand the effectiveness and usage areas of photobiomodulation therapy in the field of pediatric dentistry.

Özet

Diş hekimliğinde etkili ve güncel bir tedavi olan fotobiyomodülasyon terapisi invaziv olmadığı ve yan etkiye yol açmadığı için çocuk diş hekimliğinde özellikle ağız hastalıklarının tedavisinde yarar sağlayabilir. Bu derlemede çocuk diş hekimliği alanında kullanılan düşük yoğunluklu lazer ile gerçekleştirilen fotobiyomodülasyon terapisi ile ilgili yapılan güncel çalışmalara ulaşmak için literatür taraması yapılmış ve klinik uygulama alanında düşük yoğunluklu lazer kullanımının biyostimülatör etkisine değinilmiştir. Literatür incelendiğinde çocuk diş hekimliği alanında fotobiyomodülasyon terapisinin etkinliğini ve kullanım alanlarını genişletmek için daha fazla klinik araştırmanın gerekli olduğu görülmektedir.

🔖

Cite This Article

Bektaş, Ö. (2026). Photobiomodulation Therapy in Pediatric Dentistry. Dental and Medical Journal - Review, Cilt: 8 Sayı: 1, 19–36. https://ajindex.com/articles/1472725

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References (76)

  1. Tosun E, Tasar F. Oral ve maksillofasiyal cerrahide lazer kullanımı. Turkiye Klinikleri J Dental Sci-Special Topics. 2012:3.
  2. Coluzzi DJ. Fundamentals of lasers in dentistry: basic science, tissue interaction, and instrumentation. J Laser Dent. 2008;16:4-10.
  3. Neimz MH. Laser-tissue interactions: fundamentals and applications. Berlin: Springer; 2003.
  4. Alexiades-Armenakas M. Laser-mediated photodynamic therapy. Clin Dermatol. 2006;24(1):16-25.
  5. De Mello EDA, Pagnoncelli RM, Munin E, Filho MSA, De Mello GPS, Arisawa EAL, et al. Comparative histological analysis of bone healing of standardized bone defects performed with the Er:YAG laser and steel burs. Lasers Med Sci. 2008;23(3):253-60.
  6. Catone GA, Ailing CC 3rd, Smith BM. Laser applications in oral and maxillofacial surgery. Implant Dent. 1997;6(3):238.
  7. Tuner J, Hode L. Depth of penetration of laser light in tissue. Laser Partn Clinixperience. 2000;(15):1-3.
  8. Waynant RW. Lasers in medicine. Boca Raton: CRC Press; 2011.
  9. Asnaashari M, Safavi N. Application of low level lasers in dentistry (endodontic). J Lasers Med Sci. 2013;4(2):57-66.
  10. Huang YH, Zhao YY, Ou-Yang XP, Li FM, Ding JD, Li QG. A model for light-driven proton pump and transfer in bacteriorhodopsin. Chinese Phys Lett. 2003;20(6):959-61.
  11. Walsh LJ, Goharkhay K, Verheyen P, Moritz A. Low level laser therapy. Oral laser application. 2006:521-39.
  12. Parker S, Cronshaw M, Anagnostaki E, Bordin-Aykroyd SR, Lynch E. Systematic review of delivery parameters used in dental photobiomodulation therapy. Photobiomodul Photomed Laser Surg. 2019;37(12):784-97.
  13. Schindl A, Schindl M, Pernerstorfer-Schön H, Schindl L. Low-intensity laser therapy: a review. J Investig Med. 2000;48(5):312-26.
  14. Mester E, Mester AF, Mester A. The biomedical effects of laser application. Lasers Surg Med. 1985;5(1):31-9.
  15. Beauvoit B, Kitai T, Chance B. Contribution of the mitochondrial compartment to the optical properties of the rat liver: a theoretical and practical approach. Biophys J. 1994;67(6):2501-10.
  16. Karu TI, Pyatibrat LV, Kolyakov SF, Afanasyeva NI. Absorption measurements of a cell monolayer relevant to phototherapy: reduction of cytochrome c oxidase under near IR radiation. J Photochem Photobiol B Biol. 2005;81(2):98-106.
  17. De Nguyen T, Turcotte JY. Lasers in dentistry and in oral and maxillofacial surgery. J Can Dent Assoc. 1994;60(3):227-8.
  18. Kitchen SS, Partridge CJ. A review of low level laser therapy: part I: background, physiological effects and hazards. Physiotherapy. 1991;77(3):161-8.
  19. Kan B. Düşük yoğunluklu lazer uygulamasının distraksiyon osteogenezisi üzerine etkilerinin histomorfometrik ve radyolojik olarak karşılaştırmalı incelenmesi [doktora tezi]. Ankara: Hacettepe Üniversitesi Sağlık Bilimleri Enstitüsü; 2011.
  20. Yamany AA, Sayed HM. Effect of low level laser therapy on neurovascular function of diabetic peripheral neuropathy. J Adv Res. 2012;3(1):21-8.
  21. Freitas PM, Simões A. Lasers in dentistry: guide for clinical practice. Hoboken: John Wiley & Sons; 2015.
  22. Convissar RA. Principles and practice of laser dentistry. Elsevier Health Sciences; 2015. p. 251-74.
  23. Whelan HT, Buchmann EV, Dhokalia A, Whelan NT, Turner SG, Margolis DA, et al. Effect of NASA light-emitting diode irradiation wound healing. J Clin Laser Med Surg. 2001;19(6):305-14.
  24. Lim W, Lee SG, Kim I, Chung M, Kim M, Lim H, et al. The anti-inflammatory mechanism of 635 nm light-emitting-diode irradiation compared with existing COX inhibitors. Lasers Surg Med. 2007;39(7):614-21.
  25. Eells JT, Henry MM, Summerfelt P, Wong-Riley MTT, Buchmann EV, Kane M, et al. Therapeutic photobiomodulation for methanol-induced retinal toxicity. Proc Natl Acad Sci U S A. 2003;100(6):3439-44.
  26. Zhang R, Mio Y, Pratt PF, Lohr N, Warltier DC, Whelan HT, et al. Near infrared light protects cardiomyocytes from hypoxia and reoxygenation injury by a nitric oxide dependent mechanism. J Mol Cell Cardiol. 2009;46(1):4-14.
  27. Karu TI, Kolyakov SF. Exact action spectra for cellular responses relevant to phototherapy. Photomed Laser Surg. 2005;23(4):355-61.
  28. Saito S, Shimizu N. Stimulatory effects of low-power laser irradiation on bone regeneration in midpalatal suture during expansion in the rat. Am J Orthod Dentofacial Orthop. 1997;111(5):525-32.
  29. Eroğlu CN, Feslihan E. Temporomandibular eklem rahatsızlıklarının tedavisinde düşük seviyeli lazer terapi uygulaması: literatür derlemesi. Van Tıp Dergisi. 2017;24(1):59-65.
  30. Tunér J, Beck-Kristensen PH. Low-level lasers in dentistry. Principles and practice of laser dentistry. 2011:263-86.
  31. Fornaini C, Arany P, Rocca JP, Merigo E. Photobiomodulation in pediatric dentistry: a current state-of-the-art. Photobiomodul Photomed Laser Surg. 2019;37(12):798-813.
  32. Miloro M, Repasky M. Low level laser effect on neurosensory recovery after sagittal ramus osteotomy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;89(1):12-8.
  33. Seifi M, Maghzi A, Gutknecht N, Mir M, Asna-Ashari M. The effect of 904 nm low level laser on condylar growth in rats. Lasers Med Sci. 2010;25(1):61-5.
  34. Kahraman SA. Low-level laser therapy in oral and maxillofacial surgery. Oral Maxillofac Surg Clin North Am. 2004;16(2):277-88.
  35. Uysal AGDD, Güler Ç. Diş hekimliğinde lazer: bir literatür derlemesi. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi. 2012;6:44-53.
  36. Mester E, Spiry T, Szende B, Tota JG. Effect of laser rays on wound healing. Am J Surg. 1971;122(4):532-5.
  37. Hosseinpour S, Tunér J, Fekrazad R. Photobiomodulation in oral surgery: a review. Photobiomodul Photomed Laser Surg. 2019;37(12):814-25.
  38. Siposan DG, Lukacs A. Effect of low-level laser radiation on some rheological factors in human blood: an in vitro study. J Clin Laser Med Surg. 2000;18(4):185-95.
  39. Coluzzi DJ. Fundamentals of dental lasers: science and instruments. Dent Clin North Am. 2004;58(4):751-70.
  40. Kumari P, Dhull KS, Devraj IM, Agrawal PK, Thakre UA, Khan H, et al. Future of laser pediatric dentistry: emerging technologies and clinical applications. Bioinformation. 2025;21(8):2304-10.
  41. Parker PJ, Parker SP. Laser safety in dentistry. In: Lasers in dentistry—current concepts. Cham: Springer International Publishing; 2024. p. 97-125.
  42. Spanemberg JC, De Figueiredo MAZ, Cherubini K, Salum FG. Low level laser therapy: a review of its applications in the management of oral mucosal disorders. Altern Ther Health Med. 2016;22(6):24-31.
  43. Tunér J, Beck-Kristensen PH, Ross G, Ross A. Photobiomodulation in dentistry. In: Principles and practice of laser dentistry. 2015. p. 251-74.
  44. Meneguzzo DT, Lopes LA, Pallota R, Soares-Ferreira L, Lopes-Martins RÁB, Ribeiro MS. Prevention and treatment of mice paw edema by near-infrared low-level laser therapy on lymph nodes. Lasers Med Sci. 2013;28(3):973-80.
  45. Khan MK, Sharma DS, Jindal MK. Laser photobiomodulation as noninvasive therapeutic modality in pediatric endodontics: a comprehensive review. Journal of the Scientific Society. 2024;51(2):147-52.
  46. Takeda Y. Irradiation effect of low-energy laser on alveolar bone after tooth extraction: experimental study in rats. Int J Oral Maxillofac Surg. 1988;17(6):388-91.
  47. Muñoz Sanchez PJ, Capote Femenías JL, Díaz Tejeda A, Tunér J. The effect of 670-nm low laser therapy on herpes simplex type 1. Photomed Laser Surg. 2012;30(1):37-40.
  48. Do Prado RF, El Abras Ankha M del V, Bueno DAG, De Souza Santos EL, Tini ÍRP, Ramos CJ, et al. Cap coating and low-level laser therapy to stimulate early bone formation and improve fixation of rough threaded implants. Implant Dent. 2018;27(6):660-6.
  49. Da Silva APRB, Petri AD, Crippa GE, Stuani AS, Stuani AS, Rosa AL, et al. Effect of low-level laser therapy after rapid maxillary expansion on proliferation and differentiation of osteoblastic cells. Lasers Med Sci. 2012;27(4):777-83.
  50. Amid R, Kadkhodazadeh M, Ahsaie MG, Hakakzadeh A. Effect of low level laser therapy on proliferation and differentiation of the cells contributing in bone regeneration. J Lasers Med Sci. 2014;5(4):163-70.
  51. Brawn P, Kwong-Hing A, Boeriu S, Clokie CM. Accelerated implant stability after LED photobiomodulation. J Dent Res. 2008;87(Spec Iss B):2021.
  52. Khadra M, Kasem N, Lyngstadaas SP, Haanæs HR, Mustafa K. Laser therapy accelerates initial attachment and subsequent behaviour of human oral fibroblasts cultured on titanium implant material: a scanning electron microscopic and histomorphometric analysis. Clin Oral Implants Res. 2005;16(2):168-75.
  53. Kim YD, Kim SS, Hwang DS, Kim SG, Kwon YH, Shin SH, et al. Effect of low-level laser treatment after installation of dental titanium implant-immunohistochemical study of RANKL, RANK, OPG: an experimental study in rats. Lasers Surg Med. 2007;39(5):441-50.
  54. Kats AG, Vilkova LA, Barabash AG, Malomud ZP, Ershova NI. Treatment of erosive-ulcerative forms of lichen planus with low-energy laser irradiation. Vestnik khirurgii imeni II Grekova. 1990;144(4):121-3.
  55. Youssef M, Ashkar S, Hamade E, Gutknecht N, Lampert F, Mir M. The effect of low-level laser therapy during orthodontic movement: a preliminary study. Lasers Med Sci. 2008;23(1):27-33.
  56. Honmura A, Yanase M, Obata J, Haruki E. Therapeutic effect of Ga-Al-As diode laser irradiation on experimentally induced inflammation in rats. Lasers Surg Med. 1992;12(4):441-9.
  57. Orbak G. Low level laser applications in periodontology. J Marmara Univ Inst Heal Sci. 2014;4(1):1.
  58. Passarella S, Casamassima E, Molinari S, Pastore D, Quagliariello E, Catalano IM, et al. Increase of proton electrochemical potential and ATP synthesis in rat liver mitochondria by HeNe laser. FEBS Lett. 1984;175(1):95-9.
  59. Pires Oliveira DAA, De Oliveira RF, Zangaro RA, Soares CP. Evaluation of low-level laser therapy of osteoblastic cells. Photomed Laser Surg. 2008;26(4):401-4.
  60. Dörtbudak O, Haas R, Mailath-Pokorny G. Biostimulation of bone marrow cells with a diode soft laser. Clin Oral Implants Res. 2000;11(6):540-5.
  61. Hopkins JT, McLoda TA, Seegmiller JG, Baxter GD. Low-level laser therapy facilitates superficial wound healing in humans: a triple-blind, sham-controlled study. J Athl Train. 2004;39(3):223-9.
  62. Adriaens PA, Edwards CA, De Boever JA, Loesche WJ. Ultrastructural observations on bacterial invasion in cementum and radicular dentin of periodontally diseased human teeth. J Periodontol. 1988;59(8):493-503.
  63. Dickers B, Lamard L, Peremans A, Geerts S, Lamy M, Limme M, et al. Temperature rise during photo-activated disinfection of root canals. Lasers Med Sci. 2009;24(1):81-5.
  64. Chan Y, Lai CH. Bactericidal effects of different laser wavelengths on periodontopathic germs in photodynamic therapy. Lasers Med Sci. 2003;18(1):51-5.
  65. Prates RA, Yamada AM, Suzuki LC, Hashimoto EMC, Cai S, Gouw-Soares S, et al. Bactericidal effect of malachite green and red laser on actinobacillus actinomycetemcomitans. J Photochem Photobiol B Biol. 2007;86(1):70-6.
  66. Luan XL, Qin YL, Bi LJ, Hu CY, Zhang ZG, Lin J, et al. Histological evaluation of the safety of toluidine blue-mediated photosensitization to periodontal tissues in mice. Lasers Med Sci. 2009;24(2):162-6.
  67. Qin YL, Luan XL, Bi LJ, Sheng YQ, Zhou CN, Zhang ZG. Comparison of toluidine blue-mediated photodynamic therapy and conventional scaling treatment for periodontitis in rats. J Periodontal Res. 2008;43(2):162-7.
  68. Kimura Y, Wilder-Smith P, Yonaga K, Matsumoto K. Treatment of dentine hypersensitivity by lasers: a review. J Clin Periodontol. 2000;27(10):715-21.
  69. De Paula Eduardo C, De Freitas PM, Esteves-Oliveira M, Aranha ACC, Ramalho KM, Simões A, et al. Laser phototherapy in the treatment of periodontal disease: a review. Lasers Med Sci. 2010;25(6):781-92.
  70. Tate Y, Yoshiba K, Yoshiba N, Iwaku M, Okiji T, Ohshima H. Odontoblast responses to GaAlAs laser irradiation in rat molars: an experimental study using heat-shock protein-25 immunohistochemistry. Eur J Oral Sci. 2006;114(1):50-7.
  71. Dilsiz A, Aydn T, Emrem G. Effects of the combined desensitizing dentifrice and diode laser therapy in the treatment of desensitization of teeth with gingival recession. Photomed Laser Surg. 2010;28(2):2.
  72. Seraj B, Bavaghar A, Hakimiha N, Hosseini Z, Kharazifard MJ, Ghadimi S. Effect of photobiomodulation therapy with an 810-nm diode laser on pain perception associated with dental injections in children: a double-blind randomized controlled clinical trial. J Lasers Med Sci. 2023;14:e19.
  73. Elbay ÜŞ, Tak Ö, Elbay M, Uğurluel C, Kaya C. Efficacy of low-level laser therapy in the management of postoperative pain in children after primary teeth extraction: a randomized clinical trial. Photomed Laser Surg. 2016;34(4):171-7.
  74. Zadik Y, Arany PR, Fregnani ER, Bossi P, Antunes HS, Bensadoun RJ, et al. Systematic review of photobiomodulation for the management of oral mucositis in cancer patients and clinical practice guidelines. Support Care Cancer. 2019;27(10):3969-83.
  75. Nadhreen A, Sabbagh H, Alamoudi N, Elkhodary H. Photobiomodulation 810 nm diode laser and formocresol for primary molar pulpotomy: a randomized clinical trial. Egyptian Dental Journal. 2021;67:19-30.
  76. Parker S, Cronshaw M, Anagnostaki E, Mylona V, Lynch E, Grootveld M. Effect of photobiomodulation therapy dosage on orthodontic movement, temporomandibular dysfunction and third molar surgery outcomes: a five-year systematic review. Applied Sciences. 2024;14(7):3049.