SavedAdd your journal

Journals / Bulletin of Biotechnology / 2026 / Volume: 5 Issue: 1

Investigation of the genetic defect of Cholesterol deficiency and Brachyspina syndrome in Holstein breed cattle breed in Eskisehir

Beste Göneci(ESKISEHIR OSMANGAZI UNIVERSITY, FACULTY OF AGRICULTURE)0000-0002-7183-0170
Muhammet Kaya(ESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ, ZİRAAT FAKÜLTESİ)0000-0001-6474-121X
Pages
—
Publication Date
2024-06-30
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this way, herds free of genetic defects can be produced.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:As a result of the intensive use of biotechnology in cattle breeding, the incidence of rare genetic defects in the population has started to increase.
📊
Key Findings & Data:With regard to these two genetic defects, in the study conducted to investigate samples were taken from the Holstein cattle reared in Eskişehir by using PCR technique. 2 and 11 cattle were found to be carriers of the BS and CD, respectively, among 112 Holstein cattle.
💡
Conclusion & Impact:In this way, herds free of genetic defects can be produced.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:ABOP genes · Brachyspina Syndrome · Cholesterol Deficiency

Abstract

As a result of the intensive use of biotechnology in cattle breeding, the incidence of rare genetic defects in the population has started to increase. Studies have focused on identifying cattle with genetic defects using molecular methods. Identifying carrier cattle is crucial to reducing genetic defects in future generations. In a previous study conducted in Turkiye, Brachyspina Syndrome (BS) and Cholesterol Deficiency (CD) were detected in Holstein cattle. With regard to these two genetic defects, in the study conducted to investigate samples were taken from the Holstein cattle reared in Eskişehir by using PCR technique. 2 and 11 cattle were found to be carriers of the BS and CD, respectively, among 112 Holstein cattle. The possibility of the spread of genetic defects and economic damage can be prevented using molecular techniques. Some molecular methods can be used to detect genetic diseases. In this way, herds free of genetic defects can be produced.

🔖

Cite This Article

Göneci, B., Kaya, M. (2024). Investigation of the genetic defect of Cholesterol deficiency and Brachyspina syndrome in Holstein breed cattle breed in Eskisehir. Bulletin of Biotechnology, Volume: 5 Issue: 1. https://doi.org/10.51539/biotech.1408472

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (18)

  1. Agerholm JS (2007) Inherited disorders in Danish cattle, APMIS 115:1-76
  2. Agerholm JS, McEvoy F, Arnbjerg J (2006) Brachyspina syndrome in a Holstein calf. J Vet Diagn Invest 18:418-422
  3. Agerholm JS, Peperkamp K (2007) Familial occurrence of Danish and Dutch cases of the bovine brachyspina syndrome. BMC Vet Res 3:8
  4. Agerholm JS, DeLay J, Hicks B, Fredholm M (2010) First confirmed case of the bovine brachyspina syndrome in Canada. Can Vet J 51:1349-1350
  5. Bedir Dibıc K (2021) Türkiye’de Yetiştirilen Yerli Sığır ve Siyah Alaca Sığır Irklarında Brachyspina Sendromu ve Kolesterol Eksikliği Genetik Kusurlarının Belirlenmesi. Akdeniz Üniversitesi Fen Bilimleri Ensitüsü Tarımsal Biyoteknoloji Antalya
  6. Buck BC, Ulrich R, Wöhlke A, Kuiper H, Baumgärtner W. (2010) Vertebral and multiple organ malformations in a black and white German Holstein calf. Berliner Und Münchener Tierärztliche Wochenschrift 123:251-255
  7. Charlier C, Agerholm JS, Coppieters W., et al. (2012) A deletion in bovine FANCI gene compromises fertility by causing fetal death and brachyspine, PLoS ONE 7(8)
  8. Chao CH, Chen YM, Lee KH (2020) Genotype screening of bovine brachyspina in Taiwan Holstein cows. Am J Anim Vet Sci 15(3):206-210
  9. Kaminski S, Rusc A (2016) Cholesterol deficiency-new genetic defect transtmitted to Polish Holstein-Fresian cattle. Pol J Vet Sci 19(4):885-887
  10. Kipp S, Segelke D, Reinhardt F, Reents R, Schierenbeck S, Wurmser C, Pausch H, Fries R, Thaller G, Tetens J, Pott J (2015) A new Holstein haplotype affecting calf survival. Interbull Bulletin p.49
  11. Li Y, Zhai L, Fang L, Zhang S, Liu L, Zhu Y, Xue J, Xiaoqing L, Qiao L, Sun D (2016) A novel multiplex polymerase chain reaction method for the identification of brachyspina syndrome carriers in Chinese Holstein cattle. J Vet Sci Med Diagn 5(3)
  12. Meydan H, Bedir Dibıc K, Vural O, Yıldız, M.A, Agerholm J (2023) Prevalence of carriers of cholesterol deficiency-associated APOB mutation in some native, Holstein and Simmental cattle breeds in Turkiye. Turk J Vet Anim Sci 47(6):584-587
  13. Menzi F, Besuchet‐Schmutz N, Fragnière M, Hofstetter S, Jagannathan V, Mock T, Raemy A, Studer E, Mehinagic K, Regenscheit N, Meylan M (2016) A transposable element insertion in ABOP causes cholesterol deficiency in Holstein cattle. Anim Genet 47(2):253-257
  14. OMIA (2023) https://www.omia.org/OMIA001965/9913/ Accessed: 02/05/2023
  15. Rusc A, Kaminski S (2015) Detection of brachyspina carriers within Polish Holstein-Fresian bulls. Pol J Vet Sci 18(2):453-454
  16. Schütz E, Wehrhahn C, Wanjek M, Bortfeld R, Wemheuer WE, Beck J, Brenig B (2016) The Holstein Friesian lethal haplotype 5 (HH5) results from a complete deletion of TBF1M and cholesterol deficiency (CDH) from an ERV-(LTR) insertion into the coding region of APOB. PLoS ONE 11(4):e0154602.
  17. Testoni S, Diana A, Olzi E, Gentile A (2008) Brachyspina syndrome in two Holstein calves. Vet J 177(1):144-146
  18. Schütz E, Wehrhahn C, Wanjek M, Bortfeld R, Wemheuer WE, Beck J, Brenig B (2016) The Holstein Friesian lethal haplotype 5 (HH5) results from a complete deletion of TBF1M and cholesterol deficiency (CDH) from an ERV-(LTR) insertion into the coding region of APOB. PLoS ONE 11(4):e0154602.