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Journals / Black Sea Journal of Health Science / 2026 / Cilt: 8 Sayı: 5

The Protective Role of Crocin in the Female Reproductive System

Ramazan Şimşek(ZONGULDAK BÜLENT ECEVİT ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-0793-4135
Meryem Akpolat Ferah(ZONGULDAK BÜLENT ECEVİT ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-3419-1728
Mete Keçeci(ZONGULDAK BÜLENT ECEVİT ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-2144-4730
Pages
202–211
Publication Date
2025-09-15
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Furthermore, the review will present modern scientific evidence derived from both preclinical and clinical studies regarding the application of crocin in the treatment of disorders affecting the female reproductive system.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Saffron is a highly valuable spice derived from the dried stigmas of Crocus sativus L., a plant species belonging to the Iridaceae family.
📊
Key Findings & Data:Although saffron production is predominantly concentrated in Iran, significant quantities are also produced in countries such as Türkiye, India, France, Greece, Spain, and Morocco.
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Conclusion & Impact:Furthermore, the review will present modern scientific evidence derived from both preclinical and clinical studies regarding the application of crocin in the treatment of disorders affecting the female reproductive system.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Saffron · Crocin · Crocus sativus

Abstract

Saffron is a highly valuable spice derived from the dried stigmas of Crocus sativus L., a plant species belonging to the Iridaceae family. Although saffron production is predominantly concentrated in Iran, significant quantities are also produced in countries such as Türkiye, India, France, Greece, Spain, and Morocco. The primary bioactive compounds in saffron include crocin, quercetin, and safranal. Additionally, saffron contains a range of essential nutrients, including vitamins, sugars, proteins, amino acids, vital minerals, flavonoids, and other chemical constituents. Saffron extract contains a variety of carotenoids, including crocin (crocetin di-gentiobiose ester), crocetin, crocetin di-glucose ester, and crocetin gentiobiose-glucose ester. Beyond its widespread use as a food additive, saffron extracts, which contain crocin, are utilized in traditional medicine as natural healing agents for the treatment of diseases. The therapeutic effects of crocin include antioxidant, hypolipidemic, anti-inflammatory, antifibrotic, and anticancer properties. The existing literature encompasses a substantial body of research that demonstrates the protective and therapeutic effects of crocin on the female reproductive system, employing contemporary scientific methodologies. This review offers a detailed summary of the use of crocin, a key component of saffron, which is also cultivated in the Western Black Sea region of Türkiye, within the context of traditional medicine. Furthermore, the review will present modern scientific evidence derived from both preclinical and clinical studies regarding the application of crocin in the treatment of disorders affecting the female reproductive system.

Özet

Saffron is a highly valuable spice derived from the dried stigmas of Crocus sativus L., a plant species belonging to the Iridaceae family. Although saffron production is predominantly concentrated in Iran, significant quantities are also produced in countries such as Türkiye, India, France, Greece, Spain, and Morocco. The primary bioactive compounds in saffron include crocin, quercetin, and safranal. Additionally, saffron contains a range of essential nutrients, including vitamins, sugars, proteins, amino acids, vital minerals, flavonoids, and other chemical constituents. Saffron extract contains a variety of carotenoids, including crocin (crocetin di-gentiobiose ester), crocetin, crocetin di-glucose ester, and crocetin gentiobiose-glucose ester. Beyond its widespread use as a food additive, saffron extracts, which contain crocin, are utilized in traditional medicine as natural healing agents for the treatment of diseases. The therapeutic effects of crocin include antioxidant, hypolipidemic, anti-inflammatory, antifibrotic, and anticancer properties. The existing literature encompasses a substantial body of research that demonstrates the protective and therapeutic effects of crocin on the female reproductive system, employing contemporary scientific methodologies. This review offers a detailed summary of the use of crocin, a key component of saffron, which is also cultivated in the Western Black Sea region of Türkiye, within the context of traditional medicine. Furthermore, the review will present modern scientific evidence derived from both preclinical and clinical studies regarding the application of crocin in the treatment of disorders affecting the female reproductive system.

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Cite This Article

Şimşek, R., Ferah, M. A., Keçeci, M. (2025). The Protective Role of Crocin in the Female Reproductive System. Black Sea Journal of Health Science, Cilt: 8 Sayı: 5, 202–211. https://doi.org/10.19127/bshealthscience.1677526

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