SavedAdd your journal

Journals / Biyolojik Çeşitlilik ve Koruma / 2026 / Volume: 14 Issue: 2

Melatonin and Its Importance

Melatonin ve önemi

Rabia Serpil Günhan(KONYA TEKNİK ÜNİVERSİTESİ, TEKNİK BİLİMLER MESLEK YÜKSEKOKULU)0000-0001-6360-8185
Pages
—
Publication Date
2021-08-15
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The purpose of this review is to contribute to healthy nutrition and life by examining studies investigating the importance of melatonin, its functional properties, profile in foods, and the effect of food processing on melatonin content.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Melatonin is the essential hormone that is regularly secreted by the pineal gland of mammals on a dailybasis.
📊
Key Findings & Data:Melatonin, a bioactive compound, is found in oranges, tomatoes, strawberries, grapes, cherries, oliveoil, rice, barley and walnuts and in some medicinal and aromatic plants that constitute the source of functional food and pharmaceutical raw materials consumed for health..
💡
Conclusion & Impact:The purpose of this review is to contribute to healthy nutrition and life by examining studies investigating the importance of melatonin, its functional properties, profile in foods, and the effect of food processing on melatonin content.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Melatonin · Food · Health

Abstract

Melatonin is the essential hormone that is regularly secreted by the pineal gland of mammals on a dailybasis. Melatonin is involved in many chemical, biological and physiological bio activity period in the body. The main task of melatonin is to preserve the biological clock known as 'jet lag' and to adjust its rhythm. Melatonin has antioxidant enzymes stimulating, reducing lipid peroxidation, protecting brain tissue from oxidative damage. It also prevents the proliferation of cancer cells and tumor growth. Melatonin is a compound highly soluble in water and oil. Melatonin, a bioactive compound, is found in oranges, tomatoes, strawberries, grapes, cherries, oliveoil, rice, barley and walnuts and in some medicinal and aromatic plants that constitute the source of functional food and pharmaceutical raw materials consumed for health.. The purpose of this review is to contribute to healthy nutrition and life by examining studies investigating the importance of melatonin, its functional properties, profile in foods, and the effect of food processing on melatonin content.

Özet

Melatonin memelilerin pineal bezi tarafından günlük olarak düzenli şekilde salgılanan temel hormondur. Melatonin, vücutta birçok kimyasal, biyolojik ve fizyolojik faaliyette yer almaktadır. Melatoninin asıl görevi ‘Jet lag’ olarak bilinen biyolojik saatin korunması ve ritminin ayarlanmasıdır. Melatonin antioksidan enzimleri uyarıcı, lipit peroksidasyonunu azaltıcı, beyin dokusunu oksidatif hasardan koruyucu etkiye sahiptir. Ayrıca kanser hücrelerinin çoğalmasını, tümör büyümesini engellemektedir. Melatonin suda ve yağda çözünürlüğü oldukça yüksek bir bileşiktir. Biyoaktif bir bileşik olan melatonin; portakal, domates, çilek, üzüm, kiraz, zeytinyağı, pirinç, arpa, ceviz ve sağlığa yönelik tüketilen fonksiyonel gıda ve ilaç hammaddelerinin kaynağını teşkil eden bazı tıbbi ve aromatik bitkilerde farklı bileşimlerde bulunmaktadır. Bu derlemenin amacı melatoninin önemi, fonksiyonel özellikleri, gıdalardaki profili ve gıda işlemenin melatonin içeriğine etkisi konularını araştıran çalışmaları inceleyerek sağlıklı beslenme ve yaşama katkı sağlamaktır.

🔖

Cite This Article

Günhan, R. S. (2021). Melatonin and Its Importance. Biyolojik Çeşitlilik ve Koruma, Volume: 14 Issue: 2. https://doi.org/10.46309/biodicon.2021.974766

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (62)

  1. Nabavi, S. M., Nabavi, S. F., Sureda, A., Xiao, J., Dehpour, A. R., Shirooie, S.,. & Daglia, M. (2019). Anti-inflammatory effects of Melatonin: A mechanistic review. Critical reviews in food science and nutrition, 59(sup1), S4-S16.
  2. Yakupoğlu, G., Köklü, Ş., & Korkmaz, A. (2018). Bitkilerde melatonin ve üstlendiği görevler. Tarim ve Doga Dergisi, 21(2), 264.
  3. Shneider, A., Kudriavtsev, A., & Vakhrusheva, A. (2020). Can melatonin reduce the severity of COVID-19 pandemic?. International reviews of immunology, 39(4), 153-162.
  4. Zieliński, H., Szawara-Nowak, D., & Wiczkowski, W. (2017). Determination of melatonin in bakery products using liquid chromatography coupled to tandem mass spectrometry (LC–MS/MS). Chemical Papers, 71(6), 1083-1089.
  5. Kleszczyński, K., Slominski, A. T., Steinbrink, K., & Reiter, R. J. (2020). Clinical trials for use of melatonin to fight against COVID-19 are urgently needed. Nutrients, 12(9), 2561.
  6. Zieliński, H., Szawara-Nowak, D., & Wiczkowski, W. (2017). Determination of melatonin in bakery products using liquid chromatography coupled to tandem mass spectrometry (LC–MS/MS). Chemical Papers, 71(6), 1083-1089.
  7. Chen, Z., Zhou, K., Ha, W., Chen, P., Fu, H., Shen, Y.,. & Xu, Z. (2019). Development of a low-cost, simple, fast and quantitative lateral-flow immunochromatographic assay (ICA) strip for melatonin in health foods. Food and Agricultural Immunology, 30(1), 497-509.
  8. Meng, X., Li, Y., Li, S., Zhou, Y., Gan, R. Y., Xu, D. P., & Li, H. B. (2017). Dietary sources and bioactivities of melatonin. Nutrients, 9(4), 367.
  9. Milagres, M. P., Minim, V. P., Minim, L. A., Simiqueli, A. A., Moraes, L. E., & Martino, H. S. (2014). Night milking adds value to cow's milk. Journal of the Science of Food and Agriculture, 94(8), 1688-1692.
  10. Pereira, N., Naufel, M. F., Ribeiro, E. B., Tufik, S., & Hachul, H. (2020). Influence of dietary sources of melatonin on sleep quality: A review. Journal of food science, 85(1), 5-13.
  11. Pranil, T., Moongngarm, A., & Loypimai, P. (2020). Influence of pH, temperature, and light on the stability of melatonin in aqueous solutions and fruit juices. Heliyon, 6(3), e03648.
  12. Favero, G., Franceschetti, L., Buffoli, B., Moghadasian, M. H., Reiter, R. J., Rodella, L. F., & Rezzani, R. (2017). Melatonin: Protection against age-related cardiac pathology. Ageing Research Reviews, 35, 336-349.
  13. Garaulet, M., Qian, J., Florez, J. C., Arendt, J., Saxena, R., & Scheer, F. A. (2020). Melatonin effects on glucose metabolism: time to unlock the controversy. Trends in Endocrinology & Metabolism, 31(3), 192-204.
  14. Özçelik, F., Erdem, M., Bolu, A., & Gülsün, M. (2013). Melatonin: Genel özellikleri ve psikiyatrik bozukluklardaki rolü. Psikiyatride Güncel Yaklaşımlar, 5(2), 179-203.
  15. Atasoy, Ö. B., & Erbaş, O. (2017). Melatonin hormonunun fizyolojik etkileri. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi, 3(1), 52-62.
  16. Salehi, B., Sharopov, F., Fokou, P. V. T., Kobylinska, A., Jonge, L. D., Tadio, K.,. & Iriti, M. (2019). Melatonin in medicinal and food plants: Occurrence, bioavailability, and health potential for humans. Cells, 8(7), 681.
  17. Deng, B., Xia, C., Tian, S., & Shi, H. (2021). Melatonin reduces pesticide residue, delays senescence, and improves antioxidant nutrient accumulation in postharvest jujube fruit. Postharvest Biology and Technology, 173, 111419.
  18. Anderson, G., & Reiter, R. J. (2020). Melatonin: roles in influenza, Covid‐19, and other viral infections. Reviews in medical virology, 30(3), e2109.
  19. Öztürk, G., Akbulut, K. G., & Güney, Ş. (2020). Melatonin, aging, and COVID-19: Could melatonin be beneficial for COVID-19 treatment in the elderly?. Turkish journal of medical sciences, 50(6), 1504-1512.
  20. Eker, M. E., & Karakaya, S. (2018). Akdeniz diyeti, melatonin ve sağlık. Türk Tarım-Gıda Bilim ve Teknoloji dergisi, 6(9), 1258-1266.
  21. Atasoy, N. (2019). Melatonin ve Antioksidan Etkileri. Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 9(3), 196-201.
  22. Esteban-Zubero, E., López-Pingarrón, L., Alatorre-Jiménez, M. A., Ochoa-Moneo, P., Buisac-Ramón, C., Rivas-Jiménez, M.,. & Reiter, R. J. (2017). Melatonin's role as a co-adjuvant treatment in colonic diseases: A review. Life sciences, 170, 72-81.
  23. Juhnevica‐Radenkova, K., Moreno, D. A., Ikase, L., Drudze, I., & Radenkovs, V. (2020). Naturally occurring melatonin: Sources and possible ways of its biosynthesis. Comprehensive Reviews in Food Science and Food Safety, 19(6), 4008-4030.
  24. Yılmaz, C., & Gökmen, V. (2020). Neuroactive compounds in foods: Occurrence, mechanism and potential health effects. Food Research International, 128, 108744.
  25. Arnao, M. B., & Hernández-Ruiz, J. (2018). Phytomelatonin, natural melatonin from plants as a novel dietary supplement: sources, activities and world market. Journal of Functional Foods, 48, 37-42.
  26. Essa, M. M., Hamdan, H., Chidambaram, S. B., Al-Balushi, B., Guillemin, G. J., Ojcius, D. M., & Qoronfleh, M. W. (2020). Possible role of tryptophan and melatonin in COVID-19. International Journal of Tryptophan Research, 13: 1–2. DOI: 10.1177/1178646920951832.
  27. Fernández‐Pachón, M. S., Medina, S., Herrero‐Martín, G., Cerrillo, I., Berná, G., Escudero‐López, B.,. & Gil‐Izquierdo, A. (2014). Alcoholic fermentation induces melatonin synthesis in orange juice. Journal of pineal research, 56(1), 31-38.
  28. Sehirli, A. O., Sayiner, S., & Serakinci, N. (2020). Role of melatonin in the treatment of COVID-19; as an adjuvant through cluster differentiation 147 (CD147). Molecular biology reports, 1-5.
  29. Karunanithi, D., Radhakrishna, A., Sivaraman, K. P., & Biju, V. M. N. (2014). Quantitative determination of melatonin in milk by LC-MS/MS. Journal of food science and technology, 51(4), 805-812.
  30. Mena, P., Gil-Izquierdo, Á., Moreno, D. A., Martí, N., & García-Viguera, C. (2012). Assessment of the melatonin production in pomegranate wines. LWT-Food Science and Technology, 47(1), 13-18.
  31. Amaral, F. G. D., & Cipolla-Neto, J. (2018). A brief review about melatonin, a pineal hormone. Archives of endocrinology and metabolism, 62(4), 472-479.
  32. Johns, N. P., Johns, J., Porasuphatana, S., Plaimee, P., & Sae-Teaw, M. (2013). Dietary intake of melatonin from tropical fruit altered urinary excretion of 6-sulfatoxymelatonin in healthy volunteers. Journal of agricultural and food chemistry, 61(4), 913-919.
  33. Chen, G., Huo, Y., Tan, D. X., Liang, Z., Zhang, W., & Zhang, Y. (2003). Melatonin in Chinese medicinal herbs. Life sciences, 73(1), 19-26.
  34. Özge, K. U. R. T., & Sedef, E. L. (2011). Biyoaktif bir gıda bileşeni L-karnitin: Beslenme ve sağlık açısından önemi ve biyoyararlılığı. TÜBAV Bilim Dergisi, 4(2), 97-102.
  35. Romanini, E. B., Volpato, A. M., dos Santos, J. S., de Santana, E. H. W., de Souza, C. H. B., & Ludovico, A. (2019). Melatonin concentration in cow’s milk and sources of its variation. Journal of Applied Animal Research.
  36. Feng, X., Wang, M., Zhao, Y., Han, P., & Dai, Y. (2014). Melatonin from different fruit sources, functional roles, and analytical methods. Trends in Food Science & Technology, 37(1), 21-31.
  37. Reiter, R. J., Manchester, L. C., & Tan, D. X. (2005). Melatonin in walnuts: influence on levels of melatonin and total antioxidant capacity of blood. Nutrition, 21(9), 920-924.
  38. de la Puerta, C., Carrascosa-Salmoral, M. P., García-Luna, P. P., Lardone, P. J., Herrera, J. L., Fernández-Montesinos, R.,. & Pozo, D. (2007). Melatonin is a phytochemical in olive oil. Food Chemistry, 104(2), 609-612.
  39. Rodriguez-Naranjo, M. I., Gil-Izquierdo, A., Troncoso, A. M., Cantos-Villar, E., & Garcia-Parrilla, M. C. (2011). Melatonin is synthesised by yeast during alcoholic fermentation in wines. Food Chemistry, 126(4), 1608-1613.
  40. Sae‐Teaw, M., Johns, J., Johns, N. P., & Subongkot, S. (2013). Serum melatonin levels and antioxidant capacities after consumption of pineapple, orange, or banana by healthy male volunteers. Journal of pineal research, 55(1), 58-64.
  41. Üstündağ, H., Şentürk, E., & Gül, M. (2020) Melatonin and Hyperthyroidism. Arch Basic Clin Res, 2(2): 59-64. DOI: 10.5152/ABCR.2020.03.
  42. Garcia‐Moreno, H., Calvo, J. R., & Maldonado, M. D. (2013). High levels of melatonin generated during the brewing process. Journal of pineal research, 55(1), 26-30.
  43. Pothinuch, P., & Tongchitpakdee, S. (2011). Melatonin contents in mulberry (Morus spp.) leaves: effects of sample preparation, cultivar, leaf age and tea processing. Food chemistry, 128(2), 415-419.
  44. Stürtz, M., Cerezo, A. B., Cantos-Villar, E., & Garcia-Parrilla, M. C. (2011). Determination of the melatonin content of different varieties of tomatoes (Lycopersicon esculentum) and strawberries (Fragaria ananassa). Food Chemistry, 127(3), 1329-1334.
  45. Molik, E., Bonczar, G., Żebrowska, A., Misztal, T., Pustkowiak, H., & Zięba, D. (2011). Effect of day length and exogenous melatonin on chemical composition of sheep milk. Archives Animal Breeding, 54(2), 177-187.
  46. Fernández-Cruz, E., Álvarez-Fernández, M. A., Valero, E., Troncoso, A. M., & García-Parrilla, M. C. (2017). Melatonin and derived L-tryptophan metabolites produced during alcoholic fermentation by different wine yeast strains. Food chemistry, 217, 431-437.
  47. Meng, J. F., Shi, T. C., Song, S., Zhang, Z. W., & Fang, Y. L. (2017). Melatonin in grapes and grape-related foodstuffs: A review. Food chemistry, 231, 185-191.
  48. Çalişkan, U. K., Ceylan, A. K. A., & Emrah, B. O. R. (2017). Melatonin in edible and non-edible plants. Turkish Journal of Pharmaceutical Sciences, 14(1), 75.
  49. Özen, İ. T., & Ekşi, A. (2016). Melatonin and serotonin content of the main sour cherry varieties and commercially produced sour cherry concentrates. European International Journal of Science and Technology, 5(4), 57-64.
  50. Ramakrishna, A., Giridhar, P., Sankar, K. U., & Ravishankar, G. A. (2012). Melatonin and serotonin profiles in beans of Coffea species. Journal of pineal research, 52(4), 470-476.
  51. Taş, N. G., Yılmaz, C., & Gökmen, V. (2019). Investigation of serotonin, free and protein-bound tryptophan in Turkish hazelnut varieties and effect of roasting on serotonin content. Food Research International, 120, 865-871.
  52. Riga, P., Medina, S., García-Flores, L. A., & Gil-Izquierdo, Á. (2014). Melatonin content of pepper and tomato fruits: Effects of cultivar and solar radiation. Food chemistry, 156, 347-352.
  53. Kocadağlı, T., Yılmaz, C., & Gökmen, V. (2014). Determination of melatonin and its isomer in foods by liquid chromatography tandem mass spectrometry. Food chemistry, 153, 151-156.
  54. Yılmaz, C., Kocadağlı, T., & Gokmen, V. (2014). Formation of melatonin and its isomer during bread dough fermentation and effect of baking. Journal of agricultural and food chemistry, 62(13), 2900-2905.
  55. Tan, D. X., Zanghi, B. M., Manchester, L. C., & Reiter, R. J. (2014). Melatonin identified in meats and other food stuffs: potentially nutritional impact. Journal of pineal research, 57(2), 213-218.
  56. Nabavi, S. M., Nabavi, S. F., Sureda, A., Xiao, J., Dehpour, A. R., Shirooie, S.,. & Daglia, M. (2019). Anti-inflammatory effects of Melatonin: A mechanistic review. Critical reviews in food science and nutrition, 59(sup1), S4-S16.
  57. Chen, Z., Zhou, K., Ha, W., Chen, P., Fu, H., Shen, Y.,. & Xu, Z. (2019). Development of a low-cost, simple, fast and quantitative lateral-flow immunochromatographic assay (ICA) strip for melatonin in health foods. Food and Agricultural Immunology, 30(1), 497-509.
  58. Salehi, B., Sharopov, F., Fokou, P. V. T., Kobylinska, A., Jonge, L. D., Tadio, K.,. & Iriti, M. (2019). Melatonin in medicinal and food plants: Occurrence, bioavailability, and health potential for humans. Cells, 8(7), 681.
  59. Esteban-Zubero, E., López-Pingarrón, L., Alatorre-Jiménez, M. A., Ochoa-Moneo, P., Buisac-Ramón, C., Rivas-Jiménez, M.,. & Reiter, R. J. (2017). Melatonin's role as a co-adjuvant treatment in colonic diseases: A review. Life sciences, 170, 72-81.
  60. Fernández‐Pachón, M. S., Medina, S., Herrero‐Martín, G., Cerrillo, I., Berná, G., Escudero‐López, B.,. & Gil‐Izquierdo, A. (2014). Alcoholic fermentation induces melatonin synthesis in orange juice. Journal of pineal research, 56(1), 31-38.
  61. de la Puerta, C., Carrascosa-Salmoral, M. P., García-Luna, P. P., Lardone, P. J., Herrera, J. L., Fernández-Montesinos, R.,. & Pozo, D. (2007). Melatonin is a phytochemical in olive oil. Food Chemistry, 104(2), 609-612.
  62. Çalişkan, U. K., Ceylan, A. K. A., & Emrah, B. O. R. (2017). Melatonin in edible and non-edible plants. Turkish Journal of Pharmaceutical Sciences, 14(1), 75.