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Journals / Anatomy / 2017 / Cilt: 11 - Sayı: 3

Single dose ketamine injection affects activation of cells in the nucleus accumbens of prenatally stressed rats

Elif Polat ÇORUMLU
Osman Özcan AYDIN
EMEL ULUPINAR
Journal
Anatomy
Pages
115–120
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this study, we aimed to investigate the effects of single-dose ketamine application in the activation of cells in the NAc of prenatally stressed rats.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: The nucleus accumbens (NAc) has recently been implicated in the pathophysiology of depression.
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Key Findings & Data:In animals displaying depressive-like behavior following chronic stress exposure, glutamatergic transmission increases in the NAc.
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Conclusion & Impact:In this study, we aimed to investigate the effects of single-dose ketamine application in the activation of cells in the NAc of prenatally stressed rats.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:c-Fos · ketamine · nucleus accumbens

Abstract

Objectives: The nucleus accumbens (NAc) has recently been implicated in the pathophysiology of depression. In animals displaying depressive-like behavior following chronic stress exposure, glutamatergic transmission increases in the NAc. NMDA receptor antagonist ketamine act as an antidepressant, especially in treatment-resistant cases. In this study, we aimed to investigate the effects of single-dose ketamine application in the activation of cells in the NAc of prenatally stressed rats.

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Cite This Article

ÇORUMLU, E. P., AYDIN, O. Ö., ULUPINAR, E. (2017). Single dose ketamine injection affects activation of cells in the nucleus accumbens of prenatally stressed rats. Anatomy, Cilt: 11 - Sayı: 3, 115–120. https://ajindex.com/articles/146132

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