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Journals / Anestezi Dergisi / 2019 / Cilt: 27 - Sayı: 3

Mean Platelet Volume Could it Be Used as a Predictive Marker for Mortality in Post Cardiac Arrest Patients Undergoing Targeted Temperature Management?

Ortalama Trombosit Hacmi Kardiyak Arest Sonrası Hedefe Yönelik Hipotermi Uygulanan Hastalarda Mortalite için Belirteç Olarak Kullanılabilir mi?

MAHMUT ALP KARAHAN
NURAY ALTAY
EVREN BÜYÜKFIRAT
ORHAN BİNİCİ
MEHMET KENAN EROL
BAŞAK PEHLİVAN
VELİ FAHRİ PEHLİVAN
ERDOĞAN DURAN
AHMET ATLAS
Pages
180–185
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Changes in MPV can be used to predict survival in these patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Current guidelines recommend a period of moderate targeted temperature manage- ment (TTM) for post cardiac arrest patients (PCA) to improve clinical outcomes.
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Key Findings & Data:Method: This was a single-center, retrospective cohort study included 15 patients who suffered from cardiac arrest and underwent TTM within 6 hours of cardiac arrest.
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Conclusion & Impact:Changes in MPV can be used to predict survival in these patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Current guidelines recommend a period of moderate targeted temperature manage- ment (TTM) for post cardiac arrest patients (PCA) to improve clinical outcomes. A prognostic value related to survival in patients receiving TTM was not fully established. In this study, we aimed to investigate the relationship between mean platelet volume (MPV) and mortality in PCA patients undergoing TTM. Method: This was a single-center, retrospective cohort study included 15 patients who suffered from cardiac arrest and underwent TTM within 6 hours of cardiac arrest. Hypothermia was main- tained for 48h at a target temperature of 34°C. We examined all data about characteristic fea- tures of PCA patients s as well as MPV within the first 96 hours from admission. Results: Of the 15 patients, 11 (73.3%) died during hospital stay. At time points of T0, T1, T2, T3, T4 24 hour ie. a total of 5 times hemogram values were determined. The change of all values except red cell distribution width (RDW) values over time was found to be significant (P<0.05). When surviving patients were evaluated relative to deceased patients only MPV T1, T2 and T4 values showed statistically significant changes. As MPV cut-off value of T4 7.63 was determined (AUC=1.00, 95% CI:1.00-1.00, p=0.004 with a sensitivity and specificity of 100% and 100%, respectively). Conclusion: The second day values of MPV after TTM is an independent predictor of survival in PCA patients treated with TTM. Changes in MPV can be used to predict survival in these patients.

Özet

Amaç: Mevcut kılavuzlar, kardiyak arest sonrası (PKA) hastalarda klinik sonuçları iyileştirmek adına orta derecede hedefe yönelik sıcaklık tedavisi (HYH) önermektedir. HYH alan hastalarda sağkalım ile ilgili bir prognostik değer tam olarak belirnememiştir. Bu çalışma, HYH uygulanan PKA hastalarında ortalama trombosit hacmi (OTH) ile mortalite arasındaki ilişkiyi değerlendirme- yi amaçlamıştır. Yöntem: Retrospektif olarak tek merkezde yapılan bu çalışmamıza, kardiyak arest geçiren ve 6 saat içinde için HYH uygulanan 15 hasta dahil edildi. HYH, 48 saat boyunca 34°C’lik bir hedef sıcaklıkta tutuldu. İlk 96 saat içinde PKA hastalarının karakteristik özellikleri ve OTH ile ilgili tüm veriler incelenip kayıt altına alındı. Bulgular: On beş hastanın 11’i (%73.3) hastanede kaldığı süre içinde yaşamını yitirdi. T0, T1, T2, T3, T4 24 saat aralıkları ile toplamda 5 defa hemogram değerlerine bakıldı. Kırmızı kan hücresi dağılım genişliği (RDW) değerleri hariç tüm değerlerin zaman içerisinde değişimi anlamlı bulundu (P<0.05). Yaşayan hastalar ölen hastalara göre değerlendirildiğinde yalnızca OTH T1, T2 ve T4 değerlerinde istatistiksel olarak anlamlı değişimler görüldü. T4 OTH eşik değeri olarak 7.63 olarak belirlendi. (AUC=1.00, %95 CI:1.00-1.00, p=0.004, %100 duyarlılık ve %100 özgüllük). Sonuç: OTH’deki HYH sonrası 2. gün değerleri, HYH ile tedavi edilen PKA hastalarında sağkalımın bağımsız bir belirleyicisidir. Bu hastalarda sağkalımı tahmin etmek için OTH değişikliği kullanıla- bilir.

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Cite This Article

KARAHAN, M. A., ALTAY, N., BÜYÜKFIRAT, E., BİNİCİ, O., EROL, M. K., PEHLİVAN, B., PEHLİVAN, V. F., DURAN, E., ATLAS, A. (2019). Mean Platelet Volume Could it Be Used as a Predictive Marker for Mortality in Post Cardiac Arrest Patients Undergoing Targeted Temperature Management?. Anestezi Dergisi, Cilt: 27 - Sayı: 3, 180–185. https://ajindex.com/articles/144623

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