AI Summary & Key Takeaways
AI InsightWe dropped out because of ocular side effects but ocular finding were lasted.
📌 3 Key Takeaways
Abstract
nterferon therapy has been known to produce various responses, such as creating an antiviral effect, inhibiting cell proliferation, and modulating immunity. It has been used to treat various systemic disorders, including neoplastic disease and chronic hepatitis. The agent is also known to inhibit vascular endothelial cells and angiogenesis. Various adverse effects of interferon therapy have been reported. Interferon is also known to cause ocular toxicity such as retinopathy and subconjunctival hemorrhages. Thirty patients with chronic hepatitis C between 21 and 52 years of age (female 16, male 14; mean age 40.6) were treated with interferon 2 alpha and ribavirin. Seventeen patients experienced different side effects, and one patient developed ocular toxicity. We dropped out because of ocular side effects but ocular finding were lasted.
Özet
İnterferon tedavisi antiviral etkisi yanında, hücre proliferasyonunu baskılamak, immün sistemi düzenlemek gibi değişik nedenlerle kulanılmaktadır. BU ilaçların neoplastik hastalıklar, kronik viral hepatit tedavisi yanında vasküler endotelyal hücre proliferasyonu ve anjiogenezi baskılama gibi etkileri de vardır. İnterferon tedavisinin değişik yan etkileri bulunmaktadır. Retinopati, konjunktiva altı kanamaları gibi oküler toksisiteleri de bilinir. Biz burada; kronik hepatit C tanısı alan ve interferon +ribavirin tedavisi sonrası retinopati gelişen bir vakayı sunacağız. Hastanın oküler yan etkilerden dolayı interfeon tedavisinin kesilmesine rağmen oküler bulgular uzun süre sebat etmiştir.