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Journals / BEYOGLU EYE JOURNAL / 2019 / Cilt: 4 - Sayı: 3

Treatment of Corneal Alkali Burn with Chestnut Honey, Royal Jelly, and Chestnut Honey-Royal Jelly Mixture

Kursat ATALAY
Kübra CABUK
Ahmet KIRGIZ
Aysel KARA ÇAĞLAR
Pages
196–201
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: We found better corneal healing after treatment with the RJ-CH containing eye drops concerning corneal healing sore and α4β1 integrin staining.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: The alkaline burn of the cornea usually results in a decreased vision with opacification.
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Key Findings & Data:Methods: We created an alkaline burn on the center of the corneas of four groups of Wistar rats by applying round filter paper soaked with 1 N NaOH for 30 seconds.
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Conclusion & Impact:Conclusion: We found better corneal healing after treatment with the RJ-CH containing eye drops concerning corneal healing sore and α4β1 integrin staining.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Objectives: The alkaline burn of the cornea usually results in a decreased vision with opacification. In this study, we investigated the potential role of endemic chestnut honey (CH) and royal jelly on corneal healing after an alkaline burn. Methods: We created an alkaline burn on the center of the corneas of four groups of Wistar rats by applying round filter paper soaked with 1 N NaOH for 30 seconds. The animals were treated with RJ, CH, RJ-CH combination and Na- Hyaluronate (Na-HA) eye drops. We performed a serial evaluation with anterior segment photography on the first, 7th, and 14th days of the experiment. Pathologic examination conducted with hematoxylin and eosin stains and immunostaining for SMA and α4β1 integrin. We evaluated the corneal healing process with a scoring system, which was estimating the degree of corneal edema, the size of the corneal ulcer, and limbal hyperemia. Results: There was no statistically significant difference between groups on the first, 7th, and 14th days concerning the healing scores (p=0.88, p=0.06, p=0.80, respectively). However, there were significantly better scores in the repeated measures of CH (p=0.012) and RJ-CH (p=0.00) groups. The RJ group and Na-HA group did not show a significant difference in repeated measures (p=0.19 and p=0.10, respectively). The α4β1 integrin levels on immunostaining showed a significant difference among groups on the 14th day (p=0.002). Conclusion: We found better corneal healing after treatment with the RJ-CH containing eye drops concerning corneal healing sore and α4β1 integrin staining.

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Cite This Article

ATALAY, K., CABUK, K., KIRGIZ, A., ÇAĞLAR, A. K. (2019). Treatment of Corneal Alkali Burn with Chestnut Honey, Royal Jelly, and Chestnut Honey-Royal Jelly Mixture. BEYOGLU EYE JOURNAL, Cilt: 4 - Sayı: 3, 196–201. https://ajindex.com/articles/144278

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References (16)

  1. Lu L, Reinach PS, Kao WW. Corneal epithelial wound healing. Exp Biol Med (Maywood) 2001;226:653–64
  2. Iwanami H, Ishizaki M, Fukuda Y, Takahashi H. Expression of matrix metalloproteinases (MMP)-12 by myofibroblasts during alkali- burned corneal wound healing. Curr Eye Res 2009;34:207– 14
  3. Nakao S, Kuwano T, Ishibashi T, Kuwano M, Ono M. Synergistic effect of TNF-alpha in soluble VCAM-1-induced angiogenesis through alpha 4 integrins. J Immunol 2003;170):5704–11
  4. Liu CY, Kao WW. Corneal Epithelial Wound Healing. Prog Mol Biol Transl Sci 2015;134:61–71
  5. Schrage NF, Rihawi R, Frentz M, Reim M. [Acute therapy for eye burns]. [Article in German]. Klin Monbl Augenheilkd 2004;221:253–61
  6. Zhang Y, Lu XY, Hu RJ, Fan FL, Jin XM. Evaluation of artificial tears on cornea epithelium healing. Int J Ophthalmol 2018;11:1096–101
  7. Gomes JA, Amankwah R, Powell-Richards A, Dua HS. Sodium hyaluronate (hyaluronic acid) promotes migration of human corneal epithelial cells in vitro. Br J Ophthalmol 2004;88:821–5
  8. Fallacara A, Vertuani S, Panozzo G, Pecorelli A, Valacchi G, Manfredini S. Novel Artificial Tears Containing Cross-Linked Hyaluronic Acid: An In Vitro Re-Epithelialization Study. Molecules 2017 30;22
  9. Salehi A, Jabarzare S, Neurmohamadi M, Kheiri S, Rafieian- Kopaei M. A double blind clinical trial on the efficacy of honey drop in vernal keratoconjunctivitis. Evid Based Complement Alternat Med 2014;2014:287540
  10. Mansour AM, Zein W, Haddad R, Khoury J. Bullous keratopathy treated with honey. Acta Ophthalmol Scand 2004;82:312–3
  11. Albietz JM, Lenton LM. Standardised antibacterial Manuka honey in the management of persistent post-operative corneal oedema: a case series. Clin Exp Optom 2015;98:464–72
  12. Oztürk F, Kurt E, Cerçi M, Emiroglu L, Inan U, Türker M, et al. The effect of propolis extract in experimental chemical corneal injury. Ophthalmic Res 2000;32:13–8
  13. Ker-Woon C, Abd Ghafar N, Hui CK, Mohd Yusof YA, Wan Ngah WZ. The effects of acacia honey on in vitro corneal abrasion wound healing model. BMC Cell Biol 2015;16:2
  14. Uwaydat S1, Jha P, Tytarenko R, Brown H, Wiggins M, Bora PS, et al. The use of topical honey in the treatment of corneal abrasions and endotoxin-induced keratitis in an animal model. Curr Eye Res. 2011;36:787–96
  15. Laria C, Alió JL, Ruiz-Moreno JM. Combined non-steroidal therapy in experimental corneal injury. Ophthalmic Res 1997;29:145–53
  16. Liu X, Lin Z, Zhou T, Zong R, He H, Liu Z, et al. Anti-angiogenic an