Journals / Archives of Clinical and Experimental Medicine / 2019 / Cilt: 4 - Sayı: 2

C-reactive protein and red cell distribution width as indicators of complications in patients with acute appendicitis

Akut apandisit tanısı konmuş hastalarda komplikasyon belirteçleri olarak C-reaktif protein ve kırmızı küre dağılım indisinin yeri ve önemi

Pages
76–80
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

CRP may be elevated in acute appendicitis; however, it must be kept in mind to be cautious about a potentially complicated acute appendicitis after a certain level, RDW in our study has been found to be elevated in complicated appendicitis cases; but, it may not helpful to detect for perforated or gangrenous appendicitis.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Acute appendicitis is one of the most common operations in general surgery.
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Key Findings & Data:When complicated, mortality and morbidity increases.
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Conclusion & Impact:CRP may be elevated in acute appendicitis; however, it must be kept in mind to be cautious about a potentially complicated acute appendicitis after a certain level, RDW in our study has been found to be elevated in complicated appendicitis cases; but, it may not helpful to detect for perforated or gangrenous appendicitis.
🔬Design:Review & Systematic Survey
📍Scope:2017 Verileri
⚙️Variables:akut apendisit · hematolojik testler · laboratuar analiz

Abstract

Aim: Acute appendicitis is one of the most common operations in general surgery. When complicated, mortality and morbidity increases. We aimed to find out whether use of C-reactive protein (CRP) and red cell distribution width (RDW) may help to find out development of complications with acute appendicitis at initial evaluation in an emergency department. Methods: Files of the patients who underwent operations for acute appendicitis between January 2017 and August 2017 were reviewed. Development of complications was recorded and the patients were grouped as with and without complications and were compared about age, sex RDW, CRP, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. Diagnostic efficiency of CRP and RDW on the development of complications in acute appendicitis was investigated with regression analysis and by receiver operator characteristic curve analysis. Results: Age, CRP and RDW were found to be significantly related to perforation (p<0.001 for all) (Bonferoni correction), while white blood cell (WBC), AST and ALT were found to be insignificant (p=0.052, p=0.806 and p=0.804, respectively. There was a significant correlation between RDW and CRP in the Spearman non-parametric correlation analysis (correlation coefficient r=0.244 and p<0.001). There was no significant correlation of WBC to CRP and RDW. Conclusion: CRP and RDW are biochemical parameters that help us to identify the development of complications in acute appencitis. CRP may be elevated in acute appendicitis; however, it must be kept in mind to be cautious about a potentially complicated acute appendicitis after a certain level, RDW in our study has been found to be elevated in complicated appendicitis cases; but, it may not helpful to detect for perforated or gangrenous appendicitis.

Özet

Amaç: Akut apandisit genel cerrahide en sık karşılaşılan operasyon sebeplerinden biridir. Komplike olduğu zaman mortalite ve morbidite artmaktadır. C-reaktif protein (CRP) ve kırmızı küre genişlik dağılım indisi (RDW) değerlerinin kullanılması komplike olan akut apandisit vakalarını acil servisteki ilk muayenede ayırt etmemizde faydalı olup olmadığını incelemeyi amaçladık. Yöntemler: Ocak 2017 ve Ağustos 2017 tarihleri arasında akut apandisit nedeniyle opere edilmiş olan hastaların dosyaları tarandı. Hastalar yaş, cinsiyet, CRP, RDW, alanin aminotrasferaz, aspartat aminotransferaz değerleri açısından komplike olan ve olmayan akut apandisit vakalarında karşılaştırıldı. Artmış serum CRP ve RDW değerlerinin komplike apandisit tanısı koymada ne kadar etkin olduğu regresyon analizi ve alıcı işlemci karakteristiği eğrisi analizi ile değerlendirildi. Bulgular: Yaş, RDW ve CRP, perforasyon ve gangrenöz apandisit ile belirgin olarak ilişkili olarak bulundu, p<0,001, beyaz küre, aspartat aminotransferaz (AST), alanin aminotransferaz (ALT) düzeyleri ise P değerleri açısından anlamsız olarak bulundu (sırasıyla p=0,052, p=0,806 ve p=0,804). RDW ile CRP arasında korelasyon olmakla birlikte (korelasyon katsayısı r=0,244 ve p<0,001), beyaz küre ile RDW ve CRP arasında anlamlı bir ilişki yoktu. Sonuç: CRP ve RDW komplike apandisit tanısını koymamızda biyokimsasal parametre olarak değerlendirilmelidir. CRP akut apandisit vakalarında artmış olarak tespit edilebilir ancak belli bir seviyeden sonra komplike olmuş bir apandisite işaret edebilir. RDW bizim çalışmamızda komplike apandisitlerde artmış olarak bulundu. Ancak bu yükseklik için bir eşik değer tespit edilemedi.

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Cite This Article

AKTÜRK, O. M., ÇAKIR, M., YILDIRIM, D., AKINCI, M. (2019). C-reactive protein and red cell distribution width as indicators of complications in patients with acute appendicitis. Archives of Clinical and Experimental Medicine, Cilt: 4 - Sayı: 2, 76–80. https://ajindex.com/articles/144174

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References (15)

  1. Mentes O, Eryılmaz M, Harlak A, Yaman H, Yıgıt T, Ongoru O, et al. The importance of urine 5-hydroxyindoleacetic acid levels in the early diagnosis of acute appendicitis. Am J Emerg Med. 2009;27:409-12
  2. Ma KW, Chia NH, Yeung HW, Cheung MT. If not appendicitis, then what else can it be? A retrospective review of 1492 appendectomies. Hong Kong Med J. 2010;16:12-7
  3. Gurleyik G, Gurleyik E, Cetinkaya F, Unalmiser S. Serum interleukin-6 measurement in the diagnosis of acute appendicitis. ANZ J Surg. 2002;72:665-7
  4. Petroianu A. Diagnosis of acute appendicitis. Int J Surg. 2012;10:115-9
  5. Jaffe BM, Berger DH. The appendix. Schwartz’s Principles of Surgery. 9th ed. New York: McGraw Hill; 2010. pp. 1073–91
  6. Sproston NR, Ashworth JJ. Role of C-Reactive Protein at Sites of Inflammation and Infection. Front Immunol. 2018;9:754
  7. Szalai AJ, van Ginkel FW, Dalrymple SA, Murray R, McGhee JR, Volankis JE. Testosterone and IL-6 requirements for human C-reactive protein gene expression in transgenic mice. J Immunol. 1998;160:5294–9
  8. Du Clos TW, Mold C. C-reactive protein: an activator of innate immunity and a modulator of adaptive immunity. Immunol Res. 2004;30:261–77
  9. Gurleyik E, Gurleyik G, Unalmişer S. Accuracy of serum C-reactive protein measurements in diagnosis of acute appendicitis compared with surgeon's clinical impression. Dis Colon Rectum. 1995:1270–4
  10. Lippi G, Targher G, Montagnana M, Salvagno GL, Zoppini G, Guidi GC. Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients. Arch Pathol Lab Med. 2009;133:628–32
  11. Hunziker S, Celi LA, Lee J, Howell MD. Red cell distribution width improves the simplified acute physiology score for risk prediction in unselected critically ill patients. Crit Care. 2012;16:R89
  12. Subhashree AR, Shanthi B, Parameaswari PJ. The Red Cell Distribution Width as a Sensitive Biomarker for Assessing the Pulmonary Function in Automobile Welders- A Cross Sectional Study. J Clin Diagn Res. 2013;7:89–92
  13. Dinc T, Senol K, Yildiz B, Kayilioglu I, Sozen I, Coskun F. Association between red cell distribution width and mean platelet volume with appendicitis: a myth or a fact? Bratisl Lek Listy. 2015;116:499–501
  14. Clavien PA, Sanabria JR, Strasberg SM. Proposed classification of complications of surgery with examples of utility in cholecystectomy. Surgery. 1992;111:518-26
  15. Pittman-Waller VA, Myers JG, Stewart RM, Dent DL, Page CP, Gray GA, et