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Journals / Adıyaman Üniversitesi Sağlık Bilimleri Dergisi / 2026 / Cilt: 10 Sayı: 2

Effect of tarhana soup on serum lipid profile in BALB/c male mice fed a high-fat-diet

Tarhana çorbasının yüksek yağlı diyetle beslenen BALB/c erkek farelerde serum lipit profili üzerine etkisi

Efsane Yavuz(GAZİANTEP ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-8212-9622
Mustafa Örkmez(GAZİANTEP ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-5255-0504
Mehmet Akif Bozdayı(GAZİANTEP ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-0459-0629
Seren Orhan(GAZİANTEP ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-7394-7655
Davut Sinan Kaplan(GAZİANTEP ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-4663-209X
Ayhan Balkan(GAZİANTEP ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-6475-9847
Pages
106–114
Publication Date
2024-08-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: It may have beneficial effects in many metabolic diseases, especially coronary heart disease and diabetes with its positive effects on lipid profile, epididymal adipose tissue and glucose level.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: With industrialization, there has been an increase in chronic diseases due to continuous change of nutrition.
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Key Findings & Data:Materials and Methods: Male BALB/c mice were grouped into three different strain male mice groups: control group (n=10), high fat diet (HFD) (n=10) and high fat diet supplemented with tarhana (n=10).
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Conclusion & Impact:Conclusion: It may have beneficial effects in many metabolic diseases, especially coronary heart disease and diabetes with its positive effects on lipid profile, epididymal adipose tissue and glucose level.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Fermente gıda · Yüksek yağlı diyet · Lipit profili

Abstract

Aim: With industrialization, there has been an increase in chronic diseases due to continuous change of nutrition. Tarhana is a traditional grain-based product fermented by lactic acid bacteria in Turkish cuisine. This study aims to evaluate possible effects of tarhana on the impaired lipid profile parameters and serum glucose values in male BALB/c mice fed a high-fat diet. Materials and Methods: Male BALB/c mice were grouped into three different strain male mice groups: control group (n=10), high fat diet (HFD) (n=10) and high fat diet supplemented with tarhana (n=10). Standard pellet feed was given to the control group, high-fat feed with 60% fat content in the HFD group, high-fat feed and 0.3 mL (8-10mL/kg) of tarhana were given to the other group. Results: A significant difference was detected in epididymal fat weights, lipid profiles and serum glucose values between the groups (p<0.05). Conclusion: It may have beneficial effects in many metabolic diseases, especially coronary heart disease and diabetes with its positive effects on lipid profile, epididymal adipose tissue and glucose level.

Özet

Amaç: Sanayileşme ile beslenme alışkanlıklarının değişmesine bağlı olarak kronik hastalıklarda artış meydana gelmiştir. Tarhana, Türk yemeklerinde laktik asit bakterileri tarafından fermente edilen geleneksel tahıl bazlı bir üründür. Fermente gıdalar probiyotikler, prebiyotikler ve organik bileşikler açısından oldukça zengindir. Bu araştırma, tarhananın yüksek yağlı diyetle beslenen erkek BALB/c farelerde bozulmuş lipit profili parametreleri ve serum glukoz değeri üzerindeki olası etkilerini değerlendirmeyi amaçlamaktadır. Gereç ve Yöntem: BALB/c cinsi erkek fareler üç farklı gruba ayrılmıştır: kontrol grubu (n=10), yüksek yağlı diyet (YYD) (n=10) ve tarhana ilave edilmiş YYD (n=10). Kontrol grubuna standart pelet yem, YYD grubuna %60 yağ içeriğine sahip yüksek yağlı yem diğer gruba yüksek yağlı yem+0,3 mL (8-10mL/kg) tarhana verildi. Bulgular: Gruplar arasında epididimal yağ ağırlıkları, lipid profilleri ve serum glukoz değerleri arasında anlamlı bir ilişki tespit edilmiştir (p<0.05). Sonuç: Tarhananın lipid profili, epididimal yağ dokusu ve glukoz düzeyi üzerine olumlu etkisi ile başta koroner kalp hastalığı ve diyabet olmak üzere birçok metabolik hastalıkta faydalı etkileri olabileceği düşünülmektedir.

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Cite This Article

Yavuz, E., Örkmez, M., Bozdayı, M. A., Orhan, S., Kaplan, D. S., Balkan, A. (2024). Effect of tarhana soup on serum lipid profile in BALB/c male mice fed a high-fat-diet. Adıyaman Üniversitesi Sağlık Bilimleri Dergisi, Cilt: 10 Sayı: 2, 106–114. https://doi.org/10.30569/adiyamansaglik.1478460

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References (42)

  1. Singh RB, Takahashi T, Nakaoka T, et al. Nutrition in transition from Homo sapiens to Homo economicus. The Open Nutraceuticals Journal. 2013;6(1).
  2. Fedacko J, Takahashi T, Singh RB, et al. Globalization of diets and risk of noncommunicable diseases. The Role of Functional Food Security in Global Health. Elsevier; 2019:87-107.
  3. Liu AG, Ford NA, Hu FB, Zelman KM, Mozaffarian D, Kris-Etherton PM. A healthy approach to dietary fats: understanding the science and taking action to reduce consumer confusion. Nutrition Journal. 2017;16(1):53.
  4. Curley S, Gall J, Byrne R, Yvan-Charvet L, McGillicuddy F. Metabolic Inflammation in Obesity – At the Crossroads Between Fatty Acid and Cholesterol Metabolism. Molecular Nutrition & Food Research. 08/05 2020;65:1900482. doi:10.1002/mnfr.201900482
  5. Miglioranza Scavuzzi B, Miglioranza LHdS, Henrique FC, et al. The role of probiotics on each component of the metabolic syndrome and other cardiovascular risks. Expert Opinion on Therapeutic Targets. 2015;19(8):1127-1138.
  6. Bayrakçı HA, Bilgiçli N. Influence of resistant starches on chemical and functional properties of tarhana. Journal of Food Science and Technology. 2015;52(8):5335-5340.
  7. Cruz AG, Cadena RS, Walter EH, et al. Sensory analysis: relevance for prebiotic, probiotic, and synbiotic product development. 2010;9(4):358-373.
  8. Aggarwal J, Swami G, Kumar M. Probiotics and their Effects on Metabolic Diseases: An Update. Journal of clinical and diagnostic research: JCDR. Jan 2013;7(1):173-7. doi:10.7860/jcdr/2012/5004.2701
  9. Bedani R, Rossi EA, Cavallini DCU, et al. Influence of daily consumption of synbiotic soy-based product supplemented with okara soybean by-product on risk factors for cardiovascular diseases. Food Research International. 2015/07/01/ 2015;73:142-148. doi:https://doi.org/10.1016/j.foodres.2014.11.006
  10. da Silva TF, Casarotti SN, de Oliveira GLV, Penna ALB. The impact of probiotics, prebiotics, and synbiotics on the biochemical, clinical, and immunological markers, as well as on the gut microbiota of obese hosts. Critical Reviews in Food Science and Nutrition. 2020:1-19.
  11. Vitaglione P, Mazzone G, Lembo V, et al. Coffee prevents fatty liver disease induced by a high-fat diet by modulating pathways of the gut–liver axis. Journal of Nutritional Science. 2019;8
  12. Günbatar N, Bayiroğlu F. The Effect of a Highly Saturated Fat Diet and Intermittent Fasting Diet on Experimental Colon Cancer Development and Some Serum Inflammation Markers in Rats, 1 Adiponectin and Lipid Metabolism. Van Veterinary Journal. 2015;26(3):123-127.
  13. Sengun IY, Nielsen DS, Karapinar M, Jakobsen MJIjofm. Identification of lactic acid bacteria isolated from Tarhana, a traditional Turkish fermented food. 2009;135(2):105-111.
  14. Ray M, Hor P, Ojha D, Soren J, Singh S, Mondal KJBM. Bifidobacteria and its rice fermented products on diet induced obese mice: Analysis of physical status, serum profile and gene expressions. 2018;9(3):441-452.
  15. Lasker S, Rahman MM, Parvez F, et al. High-fat diet-induced metabolic syndrome and oxidative stress in obese rats are ameliorated by yogurt supplementation. Scientific Reports. 2019/12/27 2019;9(1):20026. doi:10.1038/s41598-019-56538-0
  16. Vitaglione P, Mazzone G, Lembo V, et al. Coffee prevents fatty liver disease induced by a high-fat diet by modulating pathways of the gut–liver axis. Journal of Nutritional Science. 2019;8:e15. e15. doi:10.1017/jns.2019.10
  17. Organization WH. https://www.who.int/en/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
  18. Türkiye İstatistik Kurumu Öİ. Accessed 08/03/2023, https://data.tuik.gov.tr/Bulten/Index?p=Causes-of-Death-Statistics-2018-30626
  19. Araştırması GBvS. https://hsgm.saglik.gov.tr/depo/haberler/Antep-tbsa-2017/G_Antep_BSA_2017.pdf
  20. Nawaz S, Shareef M, Shahid H, Mushtaq M, Sajid S, Sarfraz M. Lipid lowering effect of synthetic phenolic compound in a high-fat diet (HFD) induced hyperlipidemic mice. Matrix Science Pharma (MSP). 2017;1(1):12-16.
  21. Ruiz-Ramie JJ, Barber JL, Sarzynski MA. Effects of exercise on HDL functionality. Current Opinion in Lipidology. 2019;30(1):16-23.
  22. Yaralı SJJoBH. Education and Consultancy for Behavior Change in Obesity Management. 1(1):12-20.
  23. Hariri N, Thibault L. High-fat diet-induced obesity in animal models. Nutrition Research Reviews. 2010;23(2):270-299.
  24. Firouzi S, Barakatun-Nisak MY, Ismail A, Majid HA, Azmi KN. Role of probiotics in modulating glucose homeostasis: evidence from animal and human studies. International Journal of Food Sciences and Nutrition. 2013;64(6):780-786.
  25. Lim S-I, Lee B-Y. Anti-diabetic effect of material fermented using rice bran and soybean as the main ingredient by Bacillus sp. Journal of the Korean Society for Applied Biological Chemistry. 2010;53(2):222-229.
  26. Ray M, Hor P, Ojha D, Soren J, Singh S, Mondal K. Bifidobacteria and its rice fermented products on diet induced obese mice: analysis of physical status, serum profile and gene expressions. Beneficial Microbes. 2018;9(3):441-452.
  27. Lasker S, Rahman MM, Parvez F, et al. High-fat diet-induced metabolic syndrome and oxidative stress in obese rats are ameliorated by yogurt supplementation. Scientific Reports. 2019;9(1):1-15.
  28. Ooi L-G, Liong M-T. Cholesterol-lowering effects of probiotics and prebiotics: a review of in vivo and in vitro findings. International Journal of Molecular Sciences. 2010;11(6):2499-2522.
  29. Ali RFJJoEF. Hypocholesterolemic effects of diets containing different levels of kishk as a dried fermented milk–whole wheat mixture in experimental rats. 2016;3(2):117-123.
  30. Ali RF. Hypocholesterolemic effects of diets containing different levels of kishk as a dried fermented milk–whole wheat mixture in experimental rats. Journal of Ethnic Foods. 2016;3(2):117-123.
  31. Ahn N, Kim K. High-density lipoprotein cholesterol (HDL-C) in cardiovascular disease: effect of exercise training. Integrative Medicine Research. 2016;5(3):212-215.
  32. Morgantini C, Trifirò S, Tricò D, et al. A short-term increase in dietary cholesterol and fat intake affects high-density lipoprotein composition in healthy subjects. Nutrition, Metabolism and Cardiovascular Diseases. 2018;28(6):575-581.
  33. LI J, WU H, LIU Y, YANG L. High fat diet induced obesity model using four strains of mice: Kunming, C57BL/6, BALB/c and ICR. Experimental Animals. 2020:19-0148.
  34. 3Li S, Wu Q, Yin F, Zhu Z, He J, Barba FJ. Development of a combined trifluoroacetic acid hydrolysis and HPLC-ELSD method to identify and quantify inulin recovered from Jerusalem artichoke assisted by ultrasound extraction. Applied Sciences. 2018;8(5):710.
  35. Aparecida dos Reis S, Lopes da Conceição L, Diniz Rosa D, Maciel dos Santos Dias M, Peluzio G, do Carmo M. Mechanisms used by inulin-type fructans to improve the lipid profile. Nutricion Hospitalaria. 2015;31(2)
  36. Moshfegh AJ, Friday JE, Goldman JP, Ahuja JKC. Presence of inulin and oligofructose in the diets of Americans. The Journal of Nutrition. 1999;129(7):1407S-1411S.
  37. Şengün İY, Yahşi Y. Probiyotiklerin meyve ve sebze bazlı içeceklerde kullanımı. Akademik Gıda. 2021;19(2):208-220.
  38. Şimşekli N, Doğan İSJIÜFBED. Geleneksel ve fonksiyonel ürün olarak Maraş tarhanası. 2015;5(4):33-40.
  39. Aggarwal J, Swami G, Kumar MJJoc, JCDR dr. Probiotics and their effects on metabolic diseases: an update. 2013;7(1):173.
  40. Davani-Davari D, Negahdaripour M, Karimzadeh I, et al. Prebiotics: definition, types, sources, mechanisms, and clinical applications. 2019;8(3):92.
  41. Miremadi F, Sherkat F, Stojanovska LJJoFF. Hypocholesterolaemic effect and anti-hypertensive properties of probiotics and prebiotics: A review. 2016;25:497-510.
  42. Aggarwal J, Swami G, Kumar M. Probiotics and their Effects on Metabolic Diseases: An Update. Journal of clinical and diagnostic research: JCDR. Jan 2013;7(1):173-7. doi:10.7860/jcdr/2012/5004.2701