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Journals / Adıyaman Üniversitesi Sağlık Bilimleri Dergisi / 2026 / Cilt: 11 Sayı: 1

Incidental findings of brain magnetic resonance imaging in patients with treatment-resistant depression

Tedaviye dirençli depresyon hastalarında beyin manyetik rezonans görüntülemenin tesadüfi bulguları

Olga Bayar Kapıcı(Adana Seyhan Devlet Hastanesi)0000-0003-0863-9127
Yaşar Kapıcı(ADIYAMAN ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-9248-9426
Mehmet Şirik(ADIYAMAN ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-5543-3634
Dilek Örüm(Elazığ Fethi Sekin Şehir Hastanesi)0000-0001-8369-1553
Pages
27–36
Publication Date
2025-04-23
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: CVI, a neurodevelopmental abnormality, has been shown to be more common in patients diagnosed with TRD.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: In this study, incidental findings of brain magnetic resonance imaging (MRI) of patients diagnosed with treatment-resistant depression (TRD) were compared with healthy controls (HC).
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Key Findings & Data:Materials and Methods: The study included 68 patients with TRD (42 females, 26 males) and 72 HC (35 females, 37 males).
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Conclusion & Impact:Conclusion: CVI, a neurodevelopmental abnormality, has been shown to be more common in patients diagnosed with TRD.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Tedaviye dirençli majör depresif bozukluk · Manyetik rezonans görüntüleme · Tesadüfi bulgu

Abstract

Aim: In this study, incidental findings of brain magnetic resonance imaging (MRI) of patients diagnosed with treatment-resistant depression (TRD) were compared with healthy controls (HC). Materials and Methods: The study included 68 patients with TRD (42 females, 26 males) and 72 HC (35 females, 37 males). Global assessment scale (GAS) was administered. Results: In the TRD group, those with general cerebral atrophy were found to have significantly lower global assessment scale (GAS) scores (p<0.001). In the TRD group, those with cavum veli interpositi (CVI) were found to have significantly lower GAS scores (p=0.001). In the TRD group, when the effect of age was controlled, a significant correlation was found between the GAS score and the duration of the disorder (r=-0.400; p=0.001). Conclusion: CVI, a neurodevelopmental abnormality, has been shown to be more common in patients diagnosed with TRD.

Özet

Amaç: Bu çalışmada, tedaviye dirençli depresyon (TDD) tanılı hastaların beyin manyetik rezonans görüntüleme (MRG)’nin tesadüfi bulguları sağlıklı kontrollerle (SK) karşılaştırıldı. Gereç ve Yöntem: Çalışmaya TDD tanılı 68 hasta (42 kadın, 26 erkek) ve 72 SK (35 kadın, 37 erkek) dahil edildi. Global değerlendirme ölçeği (GDÖ) uygulandı. Bulgular: TDD grubunda, genel serebral atrofisi olanların global değerlendirme ölçeği (GDÖ) skorlarının anlamlı derecede düşük olduğu bulundu (p<0,001). TDD grubunda, kavum veli interpositi (KVİ) saptananların GDÖ skorlarının anlamlı derecede düşük olduğu bulundu (p=0,001). TDD grubunda, yaşın etkisi kontrol edildiğinde, GDÖ skoru ile bozukluk süresi arasında anlamlı bir korelasyon bulundu (r=-0,400; p=0,001). Sonuç: Nörogelişimsel bir anormallik olan KVİ'nin TDD tanılı hastalarda daha yaygın olduğu gösterilmiştir.

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Cite This Article

Kapıcı, O. B., Kapıcı, Y., Şirik, M., Örüm, D. (2025). Incidental findings of brain magnetic resonance imaging in patients with treatment-resistant depression. Adıyaman Üniversitesi Sağlık Bilimleri Dergisi, Cilt: 11 Sayı: 1, 27–36. https://doi.org/10.30569/adiyamansaglik.1573897

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