Journals / Turgut Özal Tıp Merkezi Dergisi / 2026 / Cilt: 1 Sayı: 1

The effect of hiperperistaltism induced by neostigmine to the formation of peritoneal adhesions

Neostigmin ile barsak peristaltizminin uyarılmasının peritoneal adezyon oluşumu üzerine etkisi

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Publication Date
1994-02-01
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

It is suggested that the provocation of peristaltism may be effective in preventing postoperative peritoneal adhesions. [Journal of Turgut Özal Medical Center 1(1):10-13,1994] Key words: Neostigmine, peritoneal adhesion

📌 3 Key Takeaways

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Objective & Hypothesis:Twenty Wistar rats were anaesthetised with ketamine chloride and the abdomen was opened through a midline incision 3 cm long.
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Key Findings & Data:At 3 cm right of the midline, 4x1 cm of defect including muscle and underlying peritoneum was performed.
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Conclusion & Impact:It is suggested that the provocation of peristaltism may be effective in preventing postoperative peritoneal adhesions. [Journal of Turgut Özal Medical Center 1(1):10-13,1994] Key words: Neostigmine, peritoneal adhesion
🔬Design:Makale
📍Scope:Comprehensive Sample
⚙️Variables:Neostigmin · peritoneal adezyon · Neostigmine

Abstract

Twenty Wistar rats were anaesthetised with ketamine chloride and the abdomen was opened through a midline incision 3 cm long. Omentum was tied with silk suture in one part. At 3 cm right of the midline, 4x1 cm of defect including muscle and underlying peritoneum was performed. This defect was sutured by 3-0 silk from 5 sides. One cm2 erosion was formed on anterior surface of the caecum by brushing. Then, rats were separated into two groups.25 &micro;gr/kg/im/day neostigmine was administered to study group for 7 days. All rats were sacrified and evaluated at the postoperative tenth day. There was significant difference between the control and neostigmine (p < 0.05). It is suggested that the provocation of peristaltism may be effective in preventing postoperative peritoneal adhesions. [Journal of Turgut Özal Medical Center 1(1):10-13,1994] Key words: Neostigmine, peritoneal adhesion

Özet

Her iki cinsten 20 Wistar rat'a ketamin hidroklorür anestezisi altında 3 cm'lik median kesi ile laparatomi yapıldı. Omentum bir yerinden ipek ile bağlandı. Orta hattın 3 cm sağında 4 x 1 cm'lik periton ve adele defekti oluşturuldu. Bu defekt 5 adet 3-0 ipek sütürle tek tek kapatıldı. Çekum ön yüzüne fırça ile 1 cm2'lik erozyon oluşturuldu. Denekler iki gruba ayrıldı. 10 tanesine 7 gün süre ile 25 gr/kg/gün intramusküler neostigmin uygulandı. Tüm denekler postoperatif 10. gün sakrifiye edildi ve adezyonlar değerlendirildi. Kontrol grubu ile neostigmin verilen grup arasında istatistiksel olarak anlamlı fark bulundu (p < 0.05). Postoperatif adezyonların önlenmesinde barsak peristaltizmi uyarılmasının katkısı olabileceği sonucuna varıldı. [Turgut Özal Tıp Merkezi Dergisi 1(1):10-13,1994] Anahtar kelimeler: Neostigmin, peritoneal adezyon

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Cite This Article

Erbilen, D. M., Sönmez, D., Arab, D., Şahin, D., Ertaş, D., Bülbüloğlu, D. (1994). The effect of hiperperistaltism induced by neostigmine to the formation of peritoneal adhesions. Turgut Özal Tıp Merkezi Dergisi, Cilt: 1 Sayı: 1. https://ajindex.com/articles/1434710

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