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Journals / Journal of Experimental and Clinical Medicine / 2025 / Volume: 42 Issue: 4

EBV infection as a rare cause of acute cholestatic hepatitis: A case report

Furkan Çakmak(ONDOKUZ MAYIS ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-0990-7640
Handan Doğan Çakmak(ONDOKUZ MAYIS UNIVERSITY, INTERNAL MEDICINE (DR))0009-0000-9254-3835
Pages
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Publication Date
2025-12-31
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Timely recognition may prevent unnecessary invasive procedures and ensure appropriate management.

📌 3 Key Takeaways

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Objective & Hypothesis:Epstein-Barr virus (EBV) is a common herpesvirus, often presenting as infectious mononucleosis.
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Key Findings & Data:While mild hepatic enzyme elevations are common in EBV infection, cholestatic hepatitis with significant hyperbilirubinemia is rare, occurring in less than 5% of cases.
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Conclusion & Impact:Timely recognition may prevent unnecessary invasive procedures and ensure appropriate management.
🔬Design:Case Report
📍Scope:Comprehensive Sample
⚙️Variables:ebstein-barr virus · cholestatic hepatitis · infectious mononucleosis

Abstract

Epstein-Barr virus (EBV) is a common herpesvirus, often presenting as infectious mononucleosis. While mild hepatic enzyme elevations are common in EBV infection, cholestatic hepatitis with significant hyperbilirubinemia is rare, occurring in less than 5% of cases. A 21-year-old female presented with epigastric pain and elevated liver enzymes with cholestatic pattern. Imaging excluded biliary obstruction. Serologic testing confirmed acute EBV infection. Other viral and autoimmune causes were ruled out. The patient improved with supportive care and was discharged. Although uncommon, EBV should be considered in the differential diagnosis of cholestatic hepatitis, particularly in young adults. Timely recognition may prevent unnecessary invasive procedures and ensure appropriate management.

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Cite This Article

Çakmak, F., Çakmak, H. D. (2025). EBV infection as a rare cause of acute cholestatic hepatitis: A case report. Journal of Experimental and Clinical Medicine, Volume: 42 Issue: 4. https://ajindex.com/articles/1422560

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