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Journals / Journal of Experimental and Clinical Medicine / 2026 / Volume: 43 Issue: 3

Prognostic value of the admission Fibrosis-4 index in non-traumatic subarachnoid hemorrhage

Tamer Tamdoğan(GİRESUN ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-0526-1459
Sevim Ondul(GİRESUN ÜNİVERSİTESİ)0000-0003-4219-4862
Pages
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Publication Date
2026-09-30
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Admission FIB-4 may provide a simple adjunct for early risk stratification in non-traumatic SAH.

📌 3 Key Takeaways

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Objective & Hypothesis:Early prognostic assessment after non-traumatic subarachnoid hemorrhage (SAH) remains challenging because established clinical and radiological scales primarily quantify neurological injury and may not fully reflect systemic vulnerability.
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Key Findings & Data:We investigated whether the admission Fibrosis-4 (FIB-4) index was associated with 28-day mortality and 90-day functional outcome in intensive care unit patients with non-traumatic SAH.
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Conclusion & Impact:Admission FIB-4 may provide a simple adjunct for early risk stratification in non-traumatic SAH.
🔬Design:Research Article
📍Scope:2021 Verileri
⚙️Variables:Non-traumatic subarachnoid hemorrhage · Fibrosis-4 index · Mortality

Abstract

Early prognostic assessment after non-traumatic subarachnoid hemorrhage (SAH) remains challenging because established clinical and radiological scales primarily quantify neurological injury and may not fully reflect systemic vulnerability. We investigated whether the admission Fibrosis-4 (FIB-4) index was associated with 28-day mortality and 90-day functional outcome in intensive care unit patients with non-traumatic SAH. This retrospective cohort study included 325 consecutive adults with computed tomography and/or computed tomography angiography-confirmed SAH admitted to a tertiary intensive care unit between January 2021 and June 2025. FIB-4 was calculated from age, platelet count, aspartate aminotransferase, and alanine aminotransferase measured at admission. The primary outcome was 28-day all-cause mortality; the secondary outcome was unfavorable 90-day functional status, defined as a modified Rankin Scale score of 3-6. Eighty-four patients (25.8%) died within 28 days. Median FIB-4 was higher in non-survivors than survivors (3.3 vs 1.6; p < 0.001). In multivariable logistic regression, hematocrit (odds ratio [OR] 0.857, 95% confidence interval [CI] 0.805-0.912), lactate (OR 2.693, 95% CI 1.676-4.328), and FIB-4 (OR 1.634, 95% CI 1.304-2.046) were independently associated with mortality. FIB-4 showed good discrimination (area under the curve 0.779, 95% CI 0.720-0.838), with an optimal cut-off of 2.45. Patients with FIB-4 ≥2.45 had higher 28-day mortality (52.7% vs 11.7%) and more unfavorable 90-day outcomes (77.7% vs 47.9%; both p < 0.001). Admission FIB-4 may provide a simple adjunct for early risk stratification in non-traumatic SAH.

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Cite This Article

Tamdoğan, T., Ondul, S. (2026). Prognostic value of the admission Fibrosis-4 index in non-traumatic subarachnoid hemorrhage. Journal of Experimental and Clinical Medicine, Volume: 43 Issue: 3. https://ajindex.com/articles/1422489

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