SavedAdd your journal

Journals / Journal of Experimental and Clinical Medicine / 2026 / Volume: 42 Issue: 3

The efficacy of intravenous ibuprofen and acetaminophen use for the treatment of postoperative pain following lumbar disc surgery: A randomized, double-blind study

Fatma Alkan Bayburt(GİRESUN ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-9984-4948
Azime Bulut(GİRESUN ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-8164-5617
İlke Tamdoğan(GİRESUN ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-0526-1459
Tamer Tamdoğan(GİRESUN ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-8757-1046
Pages
—
Publication Date
2025-09-30
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The results of this study suggest that IV ibuprofen administration after lumbar disc surgery is similar to acetaminophen in terms of postoperative pain perception and opioid consumption, and that acetaminophen can still be used as a potent analgesic.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Ibuprofen is a commonly used NSAID with antipyretic, analgesic, and anti-inflammatory effects.
📊
Key Findings & Data:Group I (ibuprofen group, n=35) received 800 mg IV ibuprofen; Group A (acetaminophen group, n=35) received 1000 mg IV acetaminophen.
💡
Conclusion & Impact:The results of this study suggest that IV ibuprofen administration after lumbar disc surgery is similar to acetaminophen in terms of postoperative pain perception and opioid consumption, and that acetaminophen can still be used as a potent analgesic.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:intravenous ibuprofen · acetaminophen · lumbar disc surgery

Abstract

Ibuprofen is a commonly used NSAID with antipyretic, analgesic, and anti-inflammatory effects. In this study, we compared the effects of IV ibuprofen and acetaminophen on post-operative pain intensity and opioid consumption after lumbar disc surgery. Patients in this study were randomized into two groups. Group I (ibuprofen group, n=35) received 800 mg IV ibuprofen; Group A (acetaminophen group, n=35) received 1000 mg IV acetaminophen. Demographic data including gender, age, ASA, BMI, anesthesia and surgery duration, PONV, LOS, VAS scores, and postoperative opioid consumption were recorded. There was no statistically significant difference in pain scores between the groups (p>0.05). The highest postoperative pain scores were similar between the groups, and VAS scores at discharge were also similar between the groups (p>0.05). There was no significant difference in total tramadol consumption over 24 hours (p>0.05). The results of this study suggest that IV ibuprofen administration after lumbar disc surgery is similar to acetaminophen in terms of postoperative pain perception and opioid consumption, and that acetaminophen can still be used as a potent analgesic.

🔖

Cite This Article

Bayburt, F. A., Bulut, A., Tamdoğan, İ., Tamdoğan, T. (2025). The efficacy of intravenous ibuprofen and acetaminophen use for the treatment of postoperative pain following lumbar disc surgery: A randomized, double-blind study. Journal of Experimental and Clinical Medicine, Volume: 42 Issue: 3. https://ajindex.com/articles/1422573

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (30)

  1. Oosterhuis T et al, Rehabilitation after lumbar disc surgery. Cochrane Database Syst Rev. 2014;2014(3):CD003007. Published 2014 Mar 14. doi:10.1002/14651858.CD003007.pub3
  2. Masuda S et al, Reoperation Rates of Microendoscopic Discectomy Compared With Conventional Open Lumbar Discectomy: A Large-database Study. Clin Orthop Relat Res. 2023 Jan 1;481(1):145-154. doi: 10.1097/CORR.0000000000002322. Epub 2022 Jul 15. Erratum in: Clin Orthop Relat Res. 2024 Mar 1;482(3):569. doi: 10.1097/CORR.0000000000002982. PMID: 35838602; PMCID: PMC9750527.
  3. Mirzai H et al, Perioperative Use of Corticosteroid and Bupivacaine Combination in Lumbar Disc Surgery. Spine 2002; 27: 343-6.
  4. Yücel A. Postoperatif ağrılı hastanın değerlendirilmesi ve ölçülmesi. Yücel A(ed) Postoperatif Analjezi.1.baskı. Mavimer Yayıncılık, İstanbul, 2004:27-34.
  5. Basaran B et al, Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block: a randomized double-blind study. Med Sci Monit. 2015;21:1304-1312. Published 2015 May 7. doi:10.12659/MSM.893593
  6. Persson AK et al, Prediction of Postoperative Pain From Electrical Pain Thresholds After Laparoscopic Cholecystectomy. Clin J Pain. 2017;33(2):126-131. doi:10.1097/AJP.0000000000000394
  7. Zelis R et al, Cardiocirculatory dynamics in the normal and failing heart. Annu Rev Physiol. 1981;43:455-476. doi:10.1146/annurev.ph.43.030181.002323
  8. Rawal N. Current issues in postoperative pain management. Eur J Anaesthesiol. 2016;33(3):160-171. doi:10.1097/EJA.0000000000000366
  9. Puntillo F et al, The Routes of Administration for Acute Postoperative Pain Medication. Pain Ther. 2021;10(2):909- 925. doi:10.1007/s40122-021-00286-5
  10. Mitra S et al, New Advances in Acute Postoperative Pain Management. Curr Pain Headache Rep. 2018;22(5):35. Published 2018 Apr 4. doi:10.1007/s11916-018-0690-8
  11. Apfelbaum JL et al, Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg. 2003;97(2):534-540. doi:10.1213/01.ANE.0000068822.10113.9E
  12. Jahr JS et al, Intravenous acetaminophen: a review of pharmacoeconomic science for perioperative use [published correction appears in Am J Ther. 2013 Jul-Aug;20(4):458]. Am J Ther. 2013;20(2):189-199. doi:10.1097/MJT.0b013e31828900cb
  13. Stein C. The control of pain in peripheral tissue by opioids. N Engl J Med. 1995;332(25):1685-1690. doi:10.1056/NEJM199506223322506
  14. Oderda GM et al. Opioid-related adverse drug events in surgical hospitalizations: impact on costs and length of stay. Ann Pharmacother. 2007;41(3):400-406. doi:10.1345/aph.1H386
  15. Beilin B et al. Effects of preemptive analgesia on pain and cytokine production in the postoperative period. Anesthesiology. 2003;98(1):151-155. doi:10.1097/00000542-200301000-00024
  16. Gottschalk A, Smith DS. New concepts in acute pain therapy: preemptive analgesia. Am Fam Physician. 2001;63(10):1979-1984.
  17. Dirks J et al, Mechanisms of postoperative pain: clinical indications for a contribution of central neuronal sensitization. Anesthesiology. 2002;97(6):1591-1596. doi:10.1097/00000542-200212000-00035
  18. Svensson CI, Yaksh TL. The spinal phospholipase-cyclooxygenase-prostanoid cascade in nociceptive processing. Annu Rev Pharmacol Toxicol. 2002;42:553-583. doi:10.1146/annurev.pharmtox.42.092401.143905
  19. Gritsenko K et al, Multimodal therapy in perioperative analgesia. Best Pract Res Clin Anaesthesiol. 2014;28(1):59- 79. doi:10.1016/j.bpa.2014.03.001
  20. Kehlet H. Controlling acute pain-role of preemptive analgesia, peripheral treatment and balanced analgesia and effects on outcome. Pain 1999-an updated rewiew, M Mitchell. IASP Pres, Seattle 1999: 459-62.
  21. Ljungqvist O, Scott M, Fearon KC. Enhanced Recovery After Surgery: A Review. JAMA Surg. 2017 Mar 1;152(3):292- 298. doi: 10.1001/jamasurg.2016.4952. PMID: 28097305
  22. Aitken P et al, An integrated safety analysis of combined acetaminophen and ibuprofen (Maxigesic ® /Combogesic®) in adults. J Pain Res. 2019;12:621-634. Published 2019 Feb 8. doi:10.2147/JPR.S189605
  23. Koh W et al, Intravenous non-opioid analgesia for peri- and postoperative pain management: a scientific review of intravenous acetaminophen and ibuprofen. Korean J Anesthesiol. 2015;68(1):3-12. doi:10.4097/kjae.2015.68.1.3
  24. Çelik EC et al, The comparison of single-dose preemptive intravenous ibuprofen and paracetamol on postoperative pain scores and opioid consumption after open septorhinoplasty: a randomized controlled study. Eur Arch Otorhinolaryngol. 2018;275(9):2259-2263. doi:10.1007/s00405-018-5065-6
  25. Ucar M et al, Efficacy of Intravenous Ibuprofen and Intravenous Paracetamol in Multimodal Pain Management of Postoperative Pain After Percutaneous Nephrolithotomy. J Perianesth Nurs. 2022;37(4):540-544. doi:10.1016/j.jopan.2021.10.018
  26. Akbas S et al, Efficacy of Intravenous Paracetamol and Ibuprofen on Postoperative Pain and Morphine Consumption in Lumbar Disc Surgery: Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Neurochirurgie. 2021;67(6):533-539. doi:10.1016/j.neuchi.2021.04.019
  27. Erdogan Kayhan G et al, Comparison of intravenous ibuprofen and acetaminophen for postoperative multimodal pain management in bariatric surgery: A randomized controlled trial. J Clin Anesth. 2018;50:5-11. doi:10.1016/j.jclinane.2018.06.030
  28. Gürkan Y et al, The Effect of Ibuprofen on Postoperative Opioid Consumption Following Total Hip Replacement Surgery. Turk J Anaesthesiol Reanim. 2019;47 (1):31-34. doi:10.5152/TJAR.2018.48265
  29. Mohammadian Erdi A et al, Comparing the Efficacy and Side Effects of Intravenous Ibuprofen and Acetaminophen in Pain Control Following Laparoscopic Cholecystectomy. World J Plast Surg. 2022;11 (1):117-124. doi:10.52547/wjps.11.1.117
  30. Moore RA et al, Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions. Eur J Pain. 2015;19 (9):1213-1223. doi:10.1002/ejp.649