Journals / Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi / 2026 / Cilt: 20 Sayı: 2

The Role of Systemic Inflammatory Response Markers in Differential Diagnosis of Ovarian Tumors

Over tümörlerinin ayırıcı tanısında sistemik inflamatuar belirteçlerin rolü

Pages
1769–1772
Publication Date
2023-07-03
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

N/L and P/L may be considered to distinguish the benign serous cystadenoma and serous BOT from HGSOC.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: The aim of this study is evaluating the predictive value of preoperative inflammatory blood parameters for differential of serous cystadenoma, serous borderline ovarian tumor (BOT) and high-grade serous ovarian (HGSOC) carcinoma.
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Key Findings & Data:Materials and Method: In this single-center study, we retrospectively enrolled 370 patients with ovarian tumors were divided into three groups.
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Conclusion & Impact:N/L and P/L may be considered to distinguish the benign serous cystadenoma and serous BOT from HGSOC.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Over kanseri · inflamatuar kan belirteçleri · kırmızı hücre dağılım genişliği(RDW)

Abstract

Aim: The aim of this study is evaluating the predictive value of preoperative inflammatory blood parameters for differential of serous cystadenoma, serous borderline ovarian tumor (BOT) and high-grade serous ovarian (HGSOC) carcinoma. Materials and Method: In this single-center study, we retrospectively enrolled 370 patients with ovarian tumors were divided into three groups. The groups were classified as serous cystadenoma, serous BOT and HGSOC. The potential association of preoperative hemoglobin (Hb), red cell distribution width (RDW), Hb/RDW ratio, ratio of neutrophils to lymphocytes (N/L) and ratio of platelets to lymphocytes (P/L) were analyzed. Results: P/L and N/L were significantly lower in benign serous cystadenoma or serous BOT than HGSOC (p<0.001 and p<0.001). Benign serous cystadenoma was significantly associated with lower median RDW compared to serous BOT and HGSOC (p<0.001). Hb/RDW ratio was significantly lowest in patients with HGSOC and significantly highest in patients with benign serous cystadenoma (p<0.001). Conclusion: Preoperative Hb/RDW can be used as predictor for discrimination of benign serous cystadenoma, serous BOT and HGSOC. N/L and P/L may be considered to distinguish the benign serous cystadenoma and serous BOT from HGSOC.

Özet

Amaç: Çalışmamızda preoperatif inflamatuar kan parametrelerinin benign seröz kistadenom, seröz borderline ovarian tümör (BOT) ve high grade over karsinomu (HGSOC) ayırıcı tanısındaki yerini analiz etmek amaçlandı. Gereçler ve Yöntemler: Ovaryan tümöre sahip 370 hasta retrospektif olarak 3 grup olarakdeğerlendirldi. Hastalar benign seröz kistadenom, seröz BOT ve HGSOC olarak gruplandırıldı. Preoperatif kan inflamatuar parametreleri: Hemoglobin (Hb), kırmızı hücre dağılım genişliği (RDW), Hb/RDW, Nötrofil / Lenfosit(N/L) ve Platelet/Lenfosit (P/L) oranları analiz edildi. Bulgular: P/L and N/L benign serös kist adenoma veya seröz BOT'ı da HGSOC 'ye göre önemli anlamlı derecede düşük olduğu bulundu (p<0.001 and p<0.001). Benign seröz kistadenom, seröz BOT ve HGSOC ile karşılaştırıldığında daha düşük median değere sahip olduğu saptandı (p<0.001). Hb/RDW oranı HGSOC'lu hastalarda istatiksel olarak anlamlı olarak en düşük, benign seröz kistadenomlu hastalarda anlamlı olarak en yüksekti (p<0.001). Sonuç: Preoperatif Hb/RDW, benign seröz kistadenom, seröz BOT ve HGSOC'nin ayırt edilmesinde belirleyici olarak kullanılabilir olduğunu düşünmekteyiz. N/L ve P/L, benign seröz kistadenom ve seröz BOT'ı HGSOC'den ayırt etmek için kullanılabilir .

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Cite This Article

Serdar, S., Cömert, G. K., Ceylan, Ö., Kar, İ., Yalçın, H. R., Turan, T. (2023). The Role of Systemic Inflammatory Response Markers in Differential Diagnosis of Ovarian Tumors. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi, Cilt: 20 Sayı: 2, 1769–1772. https://doi.org/10.38136/jgon.1278471

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