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Journals / International Journal of Secondary Metabolite / 2026 / Volume: 5 Issue: 3

Investigation of Chemical Composition, Antioxidant, Anticholinesterase and Anti-urease activities of Euphorbia helioscopia

Ebru Deveci(Muğla Sıtkı Koçman University, Faculty of Sciences, Department of Chemistry)
Gülsen Tel-çayan(Muğla Sıtkı Koçman University, Muğla Vocational School, Department of Chemistry and Chemical Processing Technologies)0000-0002-1916-7391
Mehmet Emin Duru(Muğla Sıtkı Koçman University, Faculty of Sciences, Department of Chemistry)
Pages
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Publication Date
2018-09-15
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The hexane extract (96.97±0.36 %) of E. helioscopia showed higher anti-urease activity than thiourea (96.93±0.17 %) whereas the essential oil (91.37±0.26 %) indicated very close anti-urease activity to the standard.

📌 3 Key Takeaways

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Objective & Hypothesis:In this study, chemical composition, antioxidant, anticholinesterase and anti-urease activities of the essential oil, hexane, acetone, methanol and water extracts of Euphorbia helioscopia were investigated.
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Key Findings & Data:The chemical composition of the essential oil was analyzed by GC and GC/MS and β -cubebene (19.3 %), palmitic acid (12.2 %) and caryophyllene oxide (11.7 %) were identified as major compounds.
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Conclusion & Impact:The hexane extract (96.97±0.36 %) of E. helioscopia showed higher anti-urease activity than thiourea (96.93±0.17 %) whereas the essential oil (91.37±0.26 %) indicated very close anti-urease activity to the standard.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Euphorbia helioscopia · Essential oil · Antioxidant activity

Abstract

In this study, chemical composition, antioxidant, anticholinesterase and anti-urease activities of the essential oil, hexane, acetone, methanol and water extracts of Euphorbia helioscopia were investigated. The chemical composition of the essential oil was analyzed by GC and GC/MS and β -cubebene (19.3 %), palmitic acid (12.2 %) and caryophyllene oxide (11.7 %) were identified as major compounds. The antioxidant activity of essential oil and extracts was performed by several methods such as β-carotene-linoleic acid, DPPH • , ABTS •+ radical scavenging, CUPRAC and metal chelating assays. The water extract showed higher antioxidant activity than BHA and α-tocopherol in β-carotene-linoleic acid, DPPH • , ABTS •+ and CUPRAC assays with IC 50 : 1.08±0.39, 15.57±0.48, 1.89±0.33 and 12.50±0.11 μg/mL values, respectively. Also, the anticholinesterase and anti-urease activities were tested against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and urease enzymes, spectrophotometrically. The acetone extract (81.23±0.58 %) showed very close BChE inhibitory activity to galantamine. The hexane extract (96.97±0.36 %) of E. helioscopia showed higher anti-urease activity than thiourea (96.93±0.17 %) whereas the essential oil (91.37±0.26 %) indicated very close anti-urease activity to the standard.

Özet

In this study, chemical composition, antioxidant, anticholinesterase and anti-urease activities of the essential oil, hexane, acetone, methanol and water extracts of Euphorbia helioscopia were investigated. The chemical composition of the essential oil was analyzed by GC and GC/MS and β-cubebene (19.3 %), palmitic acid (12.2 %) and caryophyllene oxide (11.7 %) were identified as major compounds. The antioxidant activity of essential oil and extracts was performed by several methods such as β-carotene-linoleic acid, DPPH•, ABTS•+ radical scavenging, CUPRAC and metal chelating assays. The water extract showed higher antioxidant activity than BHA and α-tocopherol in β-carotene-linoleic acid, DPPH•, ABTS•+ and CUPRAC assays with IC50: 1.08±0.39, 15.57±0.48, 1.89±0.33 and 12.50±0.11 μg/mL values, respectively. Also, the anticholinesterase and anti-urease activities were tested against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and urease enzymes, spectrophotometrically. The acetone extract (81.23±0.58 %) showed very close BChE inhibitory activity to galantamine. The hexane extract (96.97±0.36 %) of E. helioscopia showed higher anti-urease activity than thiourea (96.93±0.17 %) whereas the essential oil (91.37±0.26 %) indicated very close anti-urease activity to the standard.

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Cite This Article

Deveci, E., Tel-çayan, G., Duru, M. E. (2018). Investigation of Chemical Composition, Antioxidant, Anticholinesterase and Anti-urease activities of Euphorbia helioscopia. International Journal of Secondary Metabolite, Volume: 5 Issue: 3. https://doi.org/10.21448/ijsm.433681

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