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Journals / International Journal of Secondary Metabolite / 2026 / Volume: 11 Issue: 1

Phytochemical study and biological activities of Teucrium mideltense (Batt.) Humbert.

Hamza Elbouny(Moulay Ismail University)0000-0003-3275-3093
Brahim Ouahzizi(moulay ismail university)0000-0002-6400-5949
Kaoutar Benrahou(moulay ismail university)0000-0002-1391-6232
Abdelmonaim Homrani Bakali(Regional Agricultural Research Centre of Errachidia)0000-0003-0719-7267
Mohamed Bammou(moulay ismail university)0000-0002-9377-9337
Khalid Sellam(moulay ismail university)0000-0001-7486-2664
Chakib Alem(moulay ismail university)0000-0001-6004-7319
Pages
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Publication Date
2024-02-05
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Our findings revealed that the aqueous extract of this plant contains significant amounts of phenolic compounds (91.94 mg GAE/gE) including flavonoids (27.41 mg RE/gE).

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Teucrium mideltense (Batt.) Humbert (T. mideltense) is an endemic Moroccan species that grows exclusively in the Oriental High Atlas Mountains of Morocco.
📊
Key Findings & Data:Our findings revealed that the aqueous extract of this plant contains significant amounts of phenolic compounds (91.94 mg GAE/gE) including flavonoids (27.41 mg RE/gE).
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Conclusion & Impact:We conclude that the supplementation with the aqueous extract of T. mideltense would be effective in lowering lipids under hyperlipidemic conditions.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Teucrium mideltense · Chemical profile · Safety assessment

Abstract

Teucrium mideltense (Batt.) Humbert (T. mideltense) is an endemic Moroccan species that grows exclusively in the Oriental High Atlas Mountains of Morocco. In this work, we aim at determining the chemical profile and biological properties of the traditionally used aqueous extract of this plant. HPLC analysis, estimation of the amounts of total phenolic compounds including flavonoids, and in vitro antioxidant activity was evaluated according to the literature procedures (DPPH, ABTS, and FRAP). Additionally, safety assessment was carried out according to the organization for economic cooperation and development guidelines and the anti-hyperlipidemic activity was evaluated in triton-induced hyperlipidemic rat model. Our findings revealed that the aqueous extract of this plant contains significant amounts of phenolic compounds (91.94 mg GAE/gE) including flavonoids (27.41 mg RE/gE). HPLC analysis revealed the presence of vanillic acid, hesperidin, and rutin. Moreover, a considerable in vitro antioxidant effect was evaluated (DPPH IC50 = 36.10± 0.02 μg/mL; ABTS IC50 = 34.98± 1.31 μg/mL; FRAP EC50 = 129.74±2.18 μg/mL). Furthermore, T. mideltense (Batt.) Maire extract exerted significant lipid-lowering effects by reducing the levels of total cholesterol (-88.78%), triglycerides (-62.12%), and non-HDL cholesterol (-68.37%). We conclude that the supplementation with the aqueous extract of T. mideltense would be effective in lowering lipids under hyperlipidemic conditions.

Özet

Teucrium mideltense (Batt.) Humbert (T. mideltense) is an endemic Moroccan species that grows exclusively in the Oriental High Atlas Mountains of Morocco. In this work, we aim at determining the chemical profile and biological properties of the traditionally used aqueous extract of this plant. HPLC analysis, estimation of the amounts of total phenolic compounds including flavonoids, and in vitro antioxidant activity was evaluated according to the literature procedures (DPPH, ABTS, and FRAP). Additionally, safety assessment was carried out according to the organization for economic cooperation and development guidelines and the anti-hyperlipidemic activity was evaluated in triton-induced hyperlipidemic rat model. Our findings revealed that the aqueous extract of this plant contains significant amounts of phenolic compounds (91.94 mg GAE/gE) including flavonoids (27.41 mg RE/gE). HPLC analysis revealed the presence of vanillic acid, hesperidin, and rutin. Moreover, a considerable in vitro antioxidant effect was evaluated (DPPH IC50 = 36.10± 0.02 μg/mL; ABTS IC50 = 34.98± 1.31 μg/mL; FRAP EC50 = 129.74±2.18 μg/mL). Furthermore, T. mideltense (Batt.) Maire extract exerted significant lipid-lowering effects by reducing the levels of total cholesterol (-88.78%), triglycerides (-62.12%), and non-HDL cholesterol (-68.37%). We conclude that the supplementation with the aqueous extract of T. mideltense would be effective in lowering lipids under hyperlipidemic conditions.

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Cite This Article

Elbouny, H., Ouahzizi, B., Benrahou, K., Bakali, A. H., Bammou, M., Sellam, K., Alem, C. (2024). Phytochemical study and biological activities of Teucrium mideltense (Batt.) Humbert.. International Journal of Secondary Metabolite, Volume: 11 Issue: 1. https://doi.org/10.21448/ijsm.1364491

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