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Journals / Çukurova Anestezi ve Cerrahi Bilimler Dergisi / 2026 / Cilt: 7 Sayı: 1

Dıabetic Foot: Wound Healing, Amputation Decision, and Innovative Developments

Rana Kapukaya(Sağlık Bilimleri Üniversitesi Adana Tıp Fakültesi Şehir Hastanesi)0000-0001-9709-328X
Mehmet Bozkurt0000-0002-4480-513X
Pages
23–26
Publication Date
2024-03-11
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Innovative studies are needed to develop optimum wound surfactant molecules in this regard.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: To review the effects of diabetes-related diseases on the healing process and amputation decision in diabetic foot ulcers (DFU), negative pressure wound therapy (NPWT) results, and current treatment approaches.
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Key Findings & Data:A total of 38 patients were included in the study.
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Conclusion & Impact:Innovative studies are needed to develop optimum wound surfactant molecules in this regard.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:diabetic foot ulcer · wound healing · amputation

Abstract

Aim: To review the effects of diabetes-related diseases on the healing process and amputation decision in diabetic foot ulcers (DFU), negative pressure wound therapy (NPWT) results, and current treatment approaches. Materials and Methods: The study was planned as retrospective and cross-sectional. Data of patients who were admitted to our clinic due to DFU and were treated were examined. A total of 38 patients were included in the study. The results of patients (n=19) who underwent periodic debridement and classic dressing were compared with the results of patients (n=19) who underwent NPWT. Healing in patients was achieved by amputation (n=8), repair with partial thickness grafts or flaps (n=10), and secondary epithelialization development (n=10). The effect of diabetes-related peripheral arterial disease (PAD), cardiovascular disease (CVD), chronic kidney disease (CKD), diabetic retinopathy (DRP), and previous amputation history (AH) on recovery time was examined. The predictive importance of diabetes-related diseases for amputation was investigated. Results: It was determined that diabetes-related diseases caused a delay in wound healing. [PAD (p 0.05). The incidence of PAD was higher in patients who underwent amputation. There was no significant difference between NPWT (mean 67 days) and the classic dressing group (mean 73 days) in terms of healing time (p>0.05). Conclusion: In the presence of diabetes-related diseases, wound healing time was prolonged. This effect was more evident in the presence of DRP and CKD. This may be explained by microvascular disease, but larger series studies are needed. Wound healing was not affected in patients with AH. The incidence of PAD was found to be higher in patients who underwent amputation. Improving the care conditions of patients with diabetes and accessing treatment facilities will reduce DFU and amputation rates. No difference was found between NPWT and classic dressing in terms of healing time. However, it was observed that NBWT increased the development of granulation in the wound, reduction of edema, wound contraction, and the chance of success of the graft or flap surgery. Innovative studies are needed to develop optimum wound surfactant molecules in this regard.

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Cite This Article

Kapukaya, R., Bozkurt, M. (2024). Dıabetic Foot: Wound Healing, Amputation Decision, and Innovative Developments. Çukurova Anestezi ve Cerrahi Bilimler Dergisi, Cilt: 7 Sayı: 1, 23–26. https://doi.org/10.36516/jocass.1404365

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References (17)

  1. Chen L, Sun S, Gao Y, Ran X. Global mortality of diabetic foot ulcer: a sys-tematic review and meta-analysis of observational studies. Diabetes Obes Metab. 20 August 2022 [Epub ahead of print]. https://doi.org/10.1111/dom.14840
  2. Armstrong DG, Swerdlow MA, Armstrong AA, Conte MS, Padula WV, Bus SA. Five year mortality and direct costs of care for people with diabetic foot complications are comparable to cancer. J Foot Ankle Res 2020;13:16. https://doi.org/10.1186/s13047-020-00383-2
  3. D Haibo, L Binghui, S Qian Shen, Z Chenchen, K Liwen, C Ran, W SiYuan, et al. Mechanisms of diabetic foot ulceration: A review. Journal of Diabe-tes.2023;15:299–312. https://doi.org/10.1111/1753-0407.13372
  4. Orgill DP, Manders EK, Sumpio BE, et al. The mechanisms of action of vacuum assisted closure: More to learn. Surgery. 2009; 146:40–51. https://doi.org/10.1016/j.surg.2009.02.002
  5. Barnes JA, Eid MA, Creager MA, Goodney PP. Epidemiology and risk of amputation in patients with diabetes mellitus and peripheral artery dis-ease. Arterioscler Thromb Vasc Biol 2020; 40:1808–17. https://doi.org/10.1161/ATVBAHA.120.314595
  6. Prompers L, Schaper N, Apelqvist J, et al. Prediction of outcome in indi-viduals with diabetic foot ulcers: focus on the differences between indi-viduals with and without peripheral arterial disease. The EURODIALE Study. Diabetologia 2008; 51: 747–55. https://doi.org/10.1007/s00125-008-0940-0
  7. Newhall K, Spangler E, Dzebisashvili N, et al. Amputation rates for pa-tients with diabetes and peripheral arterial disease: the effects of race and region. Ann Vasc Surg 2016; 30: 292–298.e1
  8. Zhang Y, Cramb S, McPhail SM, et al.; Diabetic Foot Working Group, Queensland Statewide Diabetes Clinical Network, Australia. Factors asso-ciated with healing of diabetesrelated foot ulcers: observations from a large prospective real-world cohort. Diabetes Care 2021;44:e143–e145
  9. Violetta JL, Kartasasmita AS, Supriyadi Ret al. Circulating Biomarkers to Predict Diabetic Retinopathy in Patients with Diabetic Kidney Disease. Disease. Vision 2023, 7, 34. https://doi.org/10.3390/vision702003
  10. Centers for Disease Control and Prevention. National Diabetes Statis-tics Report. Atlanta, GA, Centers for Disease Control and Prevention, 2022. Accessed 6 June 2022. Available from;İ www.cdc.gov/diabetes/data/statistics-report/index.html
  11. Zhang GQ, Canner JK, Kayssi A, et al. Geographical socioeconomic disad-vantage is associated with adverse outcomes following major amputation in diabetic patients. J Vasc Surg 2021; 74: 1317–1326.e1.
  12. Hicks CW, Canner JK, Mathioudakis N, et al. Incidence and risk factors associated with ulcer recurrence among patients with diabetic foot ulcers treated in a multidisciplinary setting. J Surg Res 2020;246: 243–50.
  13. Chen J, Qin S, Liu S, Zhong K, Jing Y, Wu X, Peng F, Li D and Peng C (2023) Targeting matrix metalloproteases in diabetic wound healing. Front. Im-munol. 14:1089001. https://doi.org/10.3389/fimmu.2023.1089001
  14. Chen C, Yi Lu, Hsieh CH, et al. Advanced Biomaterials and Topical Medi-cations for Treating Diabetic Foot Ulcers: A Systematic Review and Net-work Meta-Analysis.Advances in Wound Care. http://doi.org/10.1089/wound.2023.0024
  15. Topuz S, Ciger A, Isler A, Alkan M. Effects of negative pressure wound therapy on graft success in patients with diabetic foot ulcers: A retrospec-tive study. Ann Med Res. 2023;30(8):846–50.
  16. Quacinella MA, Yong TM, Obremskey WT, Stinner DJ. Negative pressure wound therapy: Where are we in 2022? OTA Int. 2023;11:e247.
  17. Kapukaya, R, Ciloglu, O. Treatment of chronic wounds with polyure-thane sponges impregnated with boric acid particles: A randomised con-trolled trial. Int Wound J. 2020; 17: 1159–1165. https://doi.org/10.1111/iwj.13463