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Journals / Çukurova Anestezi ve Cerrahi Bilimler Dergisi / 2026 / Cilt: 8 Sayı: 2

The Role Of Neutrophil Gelatinase-Associated Lipocalin (NGAL) In The Evaluation Of Renal Functions In Patients With Liver Cirrhosis

Karaciğer Sirozlu Hastalarda Böbrek Fonskiyonlarini Değerlendirmede Nötrofil Gelatinase-Associated Lipokalin ( Ngal)’İn Rolü

Emrah Koç(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ADANA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0002-7889-3051
Mesut Aydın(VAN YÜZÜNCÜ YIL ÜNİVERSİTESİ)0000-0002-7411-1067
Mete Pekdiker(Hatay Mustafa Kemal University)0000-0003-3089-1564
Sezin Turan(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL BAKIRKÖY DR. SADİ KONUK SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0001-5885-2036
Dilek Ersil Soysal(İZMİR EKONOMİ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-0515-4300
Pages
198–202
Publication Date
2025-06-30
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

In our study, we concluded that a NGAL value of 114.17 ng/ml and above has 68.75% sensitivity and 50% specificity in indicating glomerular filtration rate.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Early diagnosis of renal dysfunction has clinical and prognostic importance for liver cirrhosis.The disadvantages are that creatinine and blood urea nitrogen (BUN) are dependent on age and muscle mass in demonstrating renal dysfunction.
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Key Findings & Data:Our aim was to investigate the sensitivity, specificity and predictive value of serum Neutrophil Gelatinase Associated Lipocalin (NGAL), serum creatinine and BUN levels against glomerular filtration rate (GFR) in the evaluation of renal function in Child A and Child B liver cirrhosis patients.
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Conclusion & Impact:In our study, we concluded that a NGAL value of 114.17 ng/ml and above has 68.75% sensitivity and 50% specificity in indicating glomerular filtration rate.
🔬Design:Review & Systematic Survey
📍Scope:2009 Verileri
⚙️Variables:siroz · renal · NGAL

Abstract

Aim: Early diagnosis of renal dysfunction has clinical and prognostic importance for liver cirrhosis.The disadvantages are that creatinine and blood urea nitrogen (BUN) are dependent on age and muscle mass in demonstrating renal dysfunction. There is a need for parameters that can detect renal dysfunction early in cirrhotic patients. Our aim was to investigate the sensitivity, specificity and predictive value of serum Neutrophil Gelatinase Associated Lipocalin (NGAL), serum creatinine and BUN levels against glomerular filtration rate (GFR) in the evaluation of renal function in Child A and Child B liver cirrhosis patients. Methods: This study was conducted in a total of 84 patients with Child A or Child B liver cirrhosis who were admitted to the gastroenterology clinic between 2009 and 2010. The study was based on retrospective review of the patients' files. Clinical and laboratory parameters were recorded. Results: We found that serum NGAL 45.8%, creatinine 88.5% and BUN 84.2% positive predictive value in defining GFR for all patients in Child A and B stages. In our study, we concluded that a NGAL value of 114.17 ng/ml and above has 68.75% sensitivity and 50% specificity in indicating glomerular filtration rate. The diagnostic utility was 47.4% and it was not found significant (p= 0.053). Conclusions: It has been shown that serum creatinine values are more sensitive and specific than BUN and a new marker, NGAL, in terms of predicting the changes that may occur in the GFR of patients in Child A and B stages.

Özet

ÖZET GİRİŞ: Renal fonksiyon bozukluğunun erken teşhisi karaciğer sirozu için klinik ve prognostik öneme sahiptir. Renal fonksiyon bozukluğunu göstermede kreatinin ve kan üre azotunun (BUN) yaş ve kas kitlesine bağımlı olması dezavantajlarıdır. Siroz hastalarında renal fonksiyon bozukluğunu erken dönemde tespit edebilecek, yukarıda bahsedilen faktörlerden etkilenmeyecek bir parametreye ihtiyaç vardır. GEREÇ YÖNTEM: Çalışmadaki amacımız Child A ve Child B karaciğer sirozlu hastalarımızın renal fonksiyonlarını glomerüler filtrasyon hızı(GFR) karşısında değerlendirirken serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) serum kreatinin ve BUN düzeylerinin duyarlık, özgüllük ve filtrasyon hızı için öngördürücü değerini araştırmaktı. SONUÇ: Çalışmamızın sonucunda Child A ve B evresindeki tüm hastalar için GFR tanımlamada serum NGAL in %45,8 kreatininin %88.5 ve BUN nin %84.2 pozitif prediktif değere sahip olduğunu gördük. Çalışmamızda NGAL değerinin 114,17 ng/ml ve üstünde olmasının glomerül filtrasyon hızını göstermede %68,75 duyarlık ve %50 özgüllüğe sahip olduğu sonucuna vardık. Tanıya yönelik yararlılık %47,4 olup, anlamlı bulunmadı.( p= 0,053). TARTIŞMA: Child A ve B evresindeki hastaların GFR lerinde oluşabilecek değişiklikleri öngörmesi açısından serum kreatinin değerlerinin BUN ve yeni bir belirteç olan NGAL den daha duyarlı ve özgül olduğunu göstermiştir. Anahtar kelimeler: Karaciğer sirozu, renal fonksiyonlar, NGAL

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Cite This Article

Koç, E., Aydın, M., Pekdiker, M., Turan, S., Soysal, D. E. (2025). The Role Of Neutrophil Gelatinase-Associated Lipocalin (NGAL) In The Evaluation Of Renal Functions In Patients With Liver Cirrhosis. Çukurova Anestezi ve Cerrahi Bilimler Dergisi, Cilt: 8 Sayı: 2, 198–202. https://doi.org/10.36516/jocass.1700542

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