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Journals / Çukurova Anestezi ve Cerrahi Bilimler Dergisi / 2026 / Cilt: 9 Sayı: 2

The Effect of Buffered Prilocaine on Injection Pain During Central Venous Port Catheter Placement

Santral Venöz Port Kateter Uygulamalarında Prilokainin Sodyum Bikarbonat ile Alkalizasyonunun Enjeksiyon Ağrısına Etkisi

Erdi Tangobay(Ankara Etlik City Hospital)0000-0003-1820-6413
Erdem Birgi(University of Health Sciences, Ankara Training and Research Hospital)0000-0001-7808-7300
Onur Ergun(Memorial Ankara Hospital)0000-0002-0495-0500
Baki Hekimoğlu(University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Department of Radiology)0000-0002-1824-5853
Pages
303–307
Publication Date
2026-06-30
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Conclusion: Buffering prilocaine with sodium bicarbonate significantly reduces injection pain during local anesthesia in central venous port catheter placement.

📌 3 Key Takeaways

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Objective & Hypothesis:Abstract Objective: This study aimed to assess whether alkalinization of 2% prilocaine with sodium bicarbonate reduces injection-related pain during central venous port catheter placement.
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Key Findings & Data:Methods: A total of 67 patients who underwent central venous port catheter placement under local anesthesia between January and December 2021 were retrospectively evaluated.
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Conclusion & Impact:Conclusion: Buffering prilocaine with sodium bicarbonate significantly reduces injection pain during local anesthesia in central venous port catheter placement.
🔬Design:Araştırma Makalesi
📍Scope:2021 Verileri
⚙️Variables:Lokal anestezi · Santral venöz kateterler · Sodyum bikarbonat

Abstract

Abstract Objective: This study aimed to assess whether alkalinization of 2% prilocaine with sodium bicarbonate reduces injection-related pain during central venous port catheter placement. Methods: A total of 67 patients who underwent central venous port catheter placement under local anesthesia between January and December 2021 were retrospectively evaluated. In all cases, non-buffered prilocaine was applied at the jugular vein access site, and injection-related pain was assessed using a 0–10 numeric rating scale. Patients were categorized into two groups based on the anesthetic solution used for port pocket (pectoral region) anesthesia. Group A consisted of patients who received buffered prilocaine (n = 37), whereas Group B included those who received non-buffered prilocaine (n = 30). The groups were compared in terms of demographic and clinical characteristics, as well as numeric pain scores for jugular and pectoral injections. Results: The two groups showed no significant differences regarding age, sex distribution, smoking history, body mass index, or pectoral subcutaneous tissue thickness (all p > 0.05). Jugular injection pain scores were similar between Group A and Group B (2.9 ± 1.4 vs. 2.9 ± 1.3, respectively; p > 0.05). In contrast, the pectoral injection pain score was significantly lower in Group A compared with Group B (2.6 ± 1.5 vs. 3.5 ± 1.6, respectively; p = 0.011). No local anesthesia–related complications or allergic reactions were observed. Conclusion: Buffering prilocaine with sodium bicarbonate significantly reduces injection pain during local anesthesia in central venous port catheter placement.

Özet

Amaç: Bu çalışmanın amacı, santral venöz port kateter uygulamalarında lokal anestezi amacıyla kullanılan %2 prilokainin sodyum bikarbonat ile alkalize edilmesinin enjeksiyon ağrısı üzerindeki etkisini değerlendirmektir. Yöntem: Ocak-Aralık 2021 tarihleri arasında lokal anestezi altında santral venöz port kateter yerleştirilen 67 hasta retrospektif olarak incelendi. Tüm hastalarda juguler ven giriş bölgesine non-tamponize prilokain uygulanarak enjeksiyona bağlı ağrı 0-10 arası numerik ağrı skalası ile kaydedildi. Hastalar port cebi (pektoral bölge) anestezisinde kullanılan solüsyona göre iki gruba ayrıldı: tamponize prilokain uygulanan hastalar Grup A (n=37) ve non-tamponize prilokain uygulanan hastalar Grup B (n=30). Gruplar demografik ve klinik özellikler ile juguler ve pektoral enjeksiyon numerik ağrı skorları açısından karşılaştırıldı. Bulgular: Gruplar arasında yaş, cinsiyet, sigara öyküsü, vücut kitle indeksi ve pektoral cilt altı kalınlığı açısından anlamlı fark saptanmadı (tümü p>0,05). Juguler enjeksiyona bağlı ağrı skorları Grup A’da 2,9 ± 1,4, Grup B’de ise 2,9 ± 1,3 olarak saptandı ve gruplar arasında istatistiksel olarak anlamlı fark saptanmadı (p>0,05). Buna karşın pektoral enjeksiyon ağrı skoru Grup A’da 2,6±1,5, Grup B’de 3,5±1,6 idi ve aradaki fark istatistiksel olarak anlamlı bulundu (p=0,011). Hiçbir hastada lokal anesteziye bağlı komplikasyon veya alerjik reaksiyon izlenmedi. Sonuç: Prilokain solusyonunun, sodyum bikarbonat ile tamponize edilmesi, santral venöz port kateter uygulamalarında lokal anestezi sırasında oluşan enjeksiyon ağrısını anlamlı düzeyde azaltmaktadır.

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Cite This Article

Tangobay, E., Birgi, E., Ergun, O., Hekimoğlu, B. (2026). The Effect of Buffered Prilocaine on Injection Pain During Central Venous Port Catheter Placement. Çukurova Anestezi ve Cerrahi Bilimler Dergisi, Cilt: 9 Sayı: 2, 303–307. https://doi.org/10.36516/jocass.1864868

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