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Journals / Çukurova Anestezi ve Cerrahi Bilimler Dergisi / 2026 / Cilt: 9 Sayı: 3

Intensive Care Management Of Adult Intoxication Cases: A Retrospective Study

Yetişkin İntoksikasyon Vakalarının Yoğun Bakım Süreçleri: Retrospektif Bir Çalışma

Nurefşan Yıldırım(KAHRAMANMARAS SUTCU IMAM UNIVERSITY)0009-0003-0901-3545
Feyza Çalışır(Kahramanmaraş Sütçü İmam Üniversitesi, Sağlık Uygulama ve Araştırma Hastanesi)0000-0002-8882-4666
Hafize Öksüz(KAHRAMANMARAS SUTCU IMAM UNIVERSITY)0000-0001-5963-6861
Gözen Öksüz(KAHRAMANMARAS SUTCU IMAM UNIVERSITY)0000-0001-5197-8031
Aykut Urfalıoğlu(KAHRAMANMARAS SUTCU IMAM UNIVERSITY)0000-0002-0657-7578
Mahmut Arslan(KAHRAMANMARAS SUTCU IMAM UNIVERSITY)0000-0002-2820-1547
Gökçe Gişi(KAHRAMANMARAS SUTCU IMAM UNIVERSITY)0000-0003-1863-6878
Pages
1028–1039
Publication Date
2026-09-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Keywords: APACHE; Critical care; Intensive care units; Lactic acid; Mortality; Poisoning

📌 3 Key Takeaways

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Objective & Hypothesis:Objective/Rationale: To evaluate the demographic characteristics, clinical course, treatment processes, and prognostic factors associated with mortality in adult intoxication cases admitted to the intensive care unit (ICU).
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Key Findings & Data:Materials and Methods: This single-center, retrospective study included 145 patients aged 18 years and older followed with a diagnosis of intoxication in the anesthesiology and reanimation ICU between January 2021 and December 2024.
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Conclusion & Impact:Keywords: APACHE; Critical care; Intensive care units; Lactic acid; Mortality; Poisoning
🔬Design:Araştırma Makalesi
📍Scope:2021 Verileri
⚙️Variables:APACHE · Laktik asit · Mortalite

Abstract

Objective/Rationale: To evaluate the demographic characteristics, clinical course, treatment processes, and prognostic factors associated with mortality in adult intoxication cases admitted to the intensive care unit (ICU). Materials and Methods: This single-center, retrospective study included 145 patients aged 18 years and older followed with a diagnosis of intoxication in the anesthesiology and reanimation ICU between January 2021 and December 2024. Demographic data, causative agent, admission clinical and laboratory findings, Glasgow Coma Scale (GCS), Acute Physiology and Chronic Health Evaluation II (APACHE II) score, treatments, and length of stay were recorded. Independent determinants of mortality were assessed by logistic regression, and the predictive performance of the APACHE II score was examined by receiver operating characteristic (ROC) analysis. Results: Of the cases, 52.4% were female, with a median age of 35 years. The most common agent was drugs (58.6%). In-hospital mortality was 6.2%. In non-survivors, the GCS was lower, the APACHE II score higher, and initial lactate higher (6.0 vs. 1.6 mmol/L) (all p<0.001). The APACHE II score was the only independent predictor of mortality (odds ratio 1.19; 95% confidence interval 1.05-1.35; p=0.005), with an area under the curve of 0.90; at a cut-off of ≥14, sensitivity was 77.8% and specificity 93.4%. Conclusion: A low GCS, high lactate, and particularly a high APACHE II score are associated with mortality. The APACHE II score is an independent predictor, supporting its value for early risk stratification in the ICU. Keywords: APACHE; Critical care; Intensive care units; Lactic acid; Mortality; Poisoning

Özet

Amaç/Gerekçe: Yoğun bakım ünitesine (YBÜ) kabul edilen erişkin intoksikasyon olgularının demografik özelliklerini, klinik seyrini, tedavi süreçlerini ve mortalite ile ilişkili prognostik faktörleri değerlendirmektir. Gereç ve Yöntemler: Bu tek merkezli, retrospektif çalışmaya Ocak 2021 - Aralık 2024 tarihleri arasında intoksikasyon tanısıyla anesteziyoloji ve reanimasyon YBÜ'sünde takip edilen 18 yaş ve üzeri 145 hasta dâhil edildi. Demografik veriler, zehirlenme etkeni, başvuru klinik ve laboratuvar bulguları, Glasgow Koma Skalası (GKS), Akut Fizyoloji ve Kronik Sağlık Değerlendirmesi II (APACHE II) skoru, uygulanan tedaviler ve yatış süreleri kaydedildi. Mortalitenin bağımsız belirleyicileri lojistik regresyon, APACHE II skorunun öngörü performansı alıcı işletim karakteristiği (ROC) analizi ile değerlendirildi. Bulgular: Olguların %52,4'ü kadın olup medyan yaş 35 yıldı. En sık etken ilaçlardı (%58,6). Hastane içi mortalite %6,2 idi. Eksitus olan grupta GKS daha düşük, APACHE II skoru daha yüksek ve ilk laktat daha yüksekti (6,0'a karşı 1,6 mmol/L) (tümü p<0,001). APACHE II skoru mortalitenin tek bağımsız prediktörüydü (olasılık oranı 1,19; %95 güven aralığı 1,05-1,35; p=0,005); eğri altında kalan alan 0,90 olup ≥14 kesim değerinde duyarlılık %77,8, özgüllük %93,4 idi. Sonuç: Düşük GKS, yüksek laktat ve özellikle yüksek APACHE II skoru mortalite ile ilişkilidir. APACHE II skoru bağımsız bir prediktör olarak öne çıkmakta ve YBÜ'de erken risk sınıflandırmasındaki değerini desteklemektedir. Anahtar Kelimeler: APACHE; Laktik asit; Mortalite; Yoğun bakım üniteleri; Yoğun bakım; Zehirlenme

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Cite This Article

Yıldırım, N., Çalışır, F., Öksüz, H., Öksüz, G., Urfalıoğlu, A., Arslan, M., Gişi, G. (2026). Intensive Care Management Of Adult Intoxication Cases: A Retrospective Study. Çukurova Anestezi ve Cerrahi Bilimler Dergisi, Cilt: 9 Sayı: 3, 1028–1039. https://doi.org/10.36516/jocass.2015882

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