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Journals / Çukurova Anestezi ve Cerrahi Bilimler Dergisi / 2026 / Cilt: 9 Sayı: 3

Effectiveness and Safety of Therapeutic Plasma Exchange in Intoxication Cases: A Single-Center Retrospective Study

Entoksikasyon Olgularında Terapötik Plazma Değişiminin Etkinliği ve Güvenilirliği: Tek Merkezli Retrospektif Bir Çalışma

Sinan Mersin(MERSIN UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, HEMATOLOGY)0000-0001-7588-6000
Pelin Aytan(MERSIN UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, HEMATOLOGY)0000-0002-4213-1565
Seher Yontar(MERSIN UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, HEMATOLOGY)0009-0005-0878-7500
Semra Denizalp(MERSIN UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, HEMATOLOGY)0009-0005-7513-0154
Mahmut Bakır Koyuncu(MERSIN UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, HEMATOLOGY)0000-0002-0507-9294
Aycan Erkenekli(MERSIN UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, HEMATOLOGY)0000-0002-2416-4507
Esin Oğuz Kozan(Adıyaman Eğitim ve Araştırma Hastanesi)0000-0002-1006-8741
Enver Tekin(MERSIN UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, HEMATOLOGY)0009-0008-9215-6921
Eyüp Naci Tiftik(MERSIN UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, HEMATOLOGY)0000-0002-3178-6005
Pages
781–789
Publication Date
2026-09-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Advanced age and thrombocytopenia are the main risk factors requiring attention regarding mortality.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: This study aimed to retrospectively evaluate clinical characteristics, procedural parameters, complication rates, and mortality-related factors in patients who underwent therapeutic plasma exchange (TPE) for intoxication.
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Key Findings & Data:Materials and Methods: Twenty-five patients (30 sessions) who underwent TPE for intoxication were included.
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Conclusion & Impact:Advanced age and thrombocytopenia are the main risk factors requiring attention regarding mortality.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:terapötik plazma değişimi · plazmaferez · entoksikasyon

Abstract

Objective: This study aimed to retrospectively evaluate clinical characteristics, procedural parameters, complication rates, and mortality-related factors in patients who underwent therapeutic plasma exchange (TPE) for intoxication. Materials and Methods: Twenty-five patients (30 sessions) who underwent TPE for intoxication were included. Demographic data, laboratory findings, procedural characteristics, and clinical outcomes were analyzed. Mann-Whitney U and Fisher's exact tests were used for intergroup comparisons; p 40 years and thrombocytopenia (PLT <100 ×10³/µL) were identified as independent risk factors for mortality (OR=28.5; p=0.016). Conclusion: TPE is an effective and safe modality in intoxication cases with a low complication rate. Advanced age and thrombocytopenia are the main risk factors requiring attention regarding mortality.

Özet

Amaç: Bu çalışmada intoksikasyon nedeniyle terapötik plazma değişimi (TPD) uygulanan hastaların klinik özellikleri, prosedür parametreleri, komplikasyon oranları ve mortaliteyle ilişkili faktörlerin retrospektif olarak değerlendirilmesi amaçlanmıştır. Materyal ve Metot: Çalışmaya intoksikasyon tanısıyla TPD uygulanan 25 hasta (30 seans) dahil edilmiştir. Demografik veriler, laboratuvar bulguları, prosedür özellikleri ve klinik sonuçlar analiz edilmiştir. Gruplar arası karşılaştırmalarda Mann-Whitney U ve Fisher kesin testi kullanılmış; p 40 yıl ve trombositopeni (PLT <100 ×10³/µL) mortalite için bağımsız risk faktörü olarak belirlendi (OR=28,5; p=0,016). Sonuç: TPD, intoksikasyon vakalarında düşük komplikasyon oranıyla etkin ve güvenilir bir yöntemdir. İleri yaş ve trombositopeni mortalite açısından dikkat gerektiren başlıca risk faktörleridir.

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Cite This Article

Mersin, S., Aytan, P., Yontar, S., Denizalp, S., Koyuncu, M. B., Erkenekli, A., Kozan, E. O., Tekin, E., Tiftik, E. N. (2026). Effectiveness and Safety of Therapeutic Plasma Exchange in Intoxication Cases: A Single-Center Retrospective Study. Çukurova Anestezi ve Cerrahi Bilimler Dergisi, Cilt: 9 Sayı: 3, 781–789. https://doi.org/10.36516/jocass.1954744

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