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Journals / Bozok Tıp Dergisi / 2026 / Cilt: 14 Sayı: 1

ASSOCIATION BETWEEN THE STAGE OF DIABETIC RETINOPATHY AND THIOL/DISULFIDE HOMEOSTASIS Diyabetik Retinopati Evresi ile Tiyol/Disülfid Homeostazı Arasındaki İlişki

Mehmet Coşkun(KARABÜK ÜNİVERSİTESİ)
İsmail Haskul(KARABÜK ÜNİVERSİTESİ)
Salim Neşelioğlu(YILDIRIM BEYAZIT ÜNİVERSİTESİ)
Özcan Erel(YILDIRIM BEYAZIT ÜNİVERSİTESİ)
Pages
40–43
Publication Date
2024-03-15
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Index 1, 2 and 3 values were not significantly different between Group 1 and 2 (p=0.83, p=0.43 and p=0.43, respectively), while significant differences were observed between Group 1 and 3 and between Group 2 and 3 (for all 3 indexes, p=0.001) Conclusion: While there was no difference between the groups in terms of disulfide levels, NTL and TTL were found to be lower as the retinopathy stage increased.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: This study investigate the association between the stage of retinopathy and thiol/disulfide homeostasis in patients with type 2 diabetes.
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Key Findings & Data:Material and Methods: Group 1, 100 diabetic patients without retinopathy; Group 2, 115 patients with nonproliferative diabetic retinopathy(NPDR); and Group 3, 72 patients with proliferative diabetic retinopathy( PDR).
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Conclusion & Impact:Index 1, 2 and 3 values were not significantly different between Group 1 and 2 (p=0.83, p=0.43 and p=0.43, respectively), while significant differences were observed between Group 1 and 3 and between Group 2 and 3 (for all 3 indexes, p=0.001) Conclusion: While there was no difference between the groups in terms of disulfide levels, NTL and TTL were found to be lower as the retinopathy stage increased.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:ASSOCIATION BETWEEN THE STAGE OF DIABETIC · RETINOPATHY AND THIOL/DISULFIDE HOMEOSTASIS · Diyabetik Retinopati Evresi ile Tiyol/Disülfid Homeostazı Arasındaki İlişki

Özet

Objective: This study investigate the association between the stage of retinopathy and thiol/disulfide homeostasis in patients with type 2 diabetes. Material and Methods: Group 1, 100 diabetic patients without retinopathy; Group 2, 115 patients with nonproliferative diabetic retinopathy(NPDR); and Group 3, 72 patients with proliferative diabetic retinopathy( PDR). Disulfide, native thiol levels (NTLs) and total thiol levels(TTLs), disulfide/NT ratio (index 1), disulfide/ TT ratio (index 2) and NT/TT ratio (index 3) of the patients were evaluated. Patients were excluded if they had cardiovascular or cerebrovascular diseases, or a diagnosis of inflammatory diseases or malignancy, if they were using any medications including lipid lowering agents, vitamins, or any antioxidants, or if they had a history of alcohol intake or smoking. Results: There was no significant difference between the groups in terms of age and gender (p=0.098 and p=0.16, respectively). No significant difference was observed between the groups with respect to disulfide levels (p=0.22). NTLs and TTLs were lowest in Group 1 and highest in Group 3. Significant differences were found in NTLs and TTLs between all groups (for NTLs, p=0.01, p=0.001 and p=0.001, respectively; for TTLs, p=0.008, p=0.001 and p=0.006, respectively). Index 1, 2 and 3 values were not significantly different between Group 1 and 2 (p=0.83, p=0.43 and p=0.43, respectively), while significant differences were observed between Group 1 and 3 and between Group 2 and 3 (for all 3 indexes, p=0.001) Conclusion: While there was no difference between the groups in terms of disulfide levels, NTL and TTL were found to be lower as the retinopathy stage increased.

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Cite This Article

Coşkun, M., Haskul, İ., Neşelioğlu, S., Erel, Ö. (2024). ASSOCIATION BETWEEN THE STAGE OF DIABETIC RETINOPATHY AND THIOL/DISULFIDE HOMEOSTASIS Diyabetik Retinopati Evresi ile Tiyol/Disülfid Homeostazı Arasındaki İlişki. Bozok Tıp Dergisi, Cilt: 14 Sayı: 1, 40–43. https://doi.org/10.16919/bozoktip.1414942

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References (11)

  1. Wild S, Roglic G, Green A, Sicree R,King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030.Diabetes Care. 2004;27:1047-53.
  2. Erel O, Neselioglu S. A novel and automated assay for thiol/ disulphide homeostasis. Clin Biochem. 2014;47:326-32.
  3. Jones DP, Liang L. Measuring the poise of thiol/disulfide couples in vivo. Free Radic Biol Med. 2009;47:1329-38.
  4. Vincent AM, Russell JW, Low P,Feldman EL. Oxidative Stress in the Pathogenesis of Diabetic Neuropathy. Endocrine Reviews. 2004;25: 612–28.
  5. Memisogullari R, Taysi S, Bakan E, Capoglu I. Antioxidant Status and Lipid Peroxidation in Type II Diabetes Mellitus. Cell Biochem Func.2003;21: 291-6.
  6. Cherubini A, Ruggiero C, Polidori MC, Mecocci P. Potential markers of oxidative stress in stroke. Free Radical Biology & Medicine. 2005;39: 841 – 52.
  7. Memişoğulları R, Bakan E. Levels of ceruloplasmin, transferrin and lipid peroxidation in the serum of patients with Type 2 diabetes mellitus. Journal of Diabetes and Its Complications. 2004;18:193-7
  8. Vural G, Gumusyayla S, Deniz O, Neselioglu S, Erel O. Thiol- Disulfide Homeostasis in Cerebral Venous Sinus Thrombosis. Clin Lab. 2018;31;64(11).
  9. Şahin E, Deveci İ, Dinç ME, Özker BY, Biçer C, ErelO. Oxidative Status in Patients with Benign Paroxysmal Positional Vertigo.J Int Adv Otol. 2018;14(2):299-303.
  10. Tuzcu A, Baykara RA, Omma A, Acet GK, Dogan E, Cure MC,et al. Thiol/Disulfide Homeostasis in Patients with Rheumatoid Arthritis. Rom J Intern Med.2018;10:1-18.
  11. Vincent AM, Russell JW, Low P,Feldman EL. Oxidative Stress in the Pathogenesis of Diabetic Neuropathy. Endocrine Reviews. 2004;25: 612–28.