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Journals / Bozok Tıp Dergisi / 2026 / Cilt: 16 Sayı: 3

EVALUATION OF ANTIBIOTIC SUSCEPTIBILITY PATTERNS AND PRESCRIPTION PRACTICES IN URINARY TRACT INFECTIONS FROM A RATIONAL DRUG USE PERSPECTIVE

Akılcı İlaç Kullanımı Perspektifinden İdrar Yolu Enfeksiyonlarında Antibiyotik Duyarlılık Profillerinin ve Reçete Uygulamalarının Değerlendirilmesi

Mehtap Şahin(Yozgat Bozok Üniversitesi, Lisansüstü Eğitim Enstitüsü, Farmakoloji Anabilim Dalı)0009-0001-2635-6633
Serkan Şahin(YOZGAT BOZOK ÜNİVERSİTESİ, TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, TIBBİ FARMAKOLOJİ ANABİLİM DALI)0000-0001-7000-6342
Tarık Küçük(yozgat Şehir Hastanesi)0000-0001-7886-5694
Pages
433–442
Publication Date
2026-09-25
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These findings highlight the urgent need for integrating antibiogram data into clinical decision-making and strengthening antimicrobial stewardship programs to promote rational antibiotic use.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: This study aimed to evaluate the distribution of uropathogens, their antibiotic susceptibility patterns, and the appropriateness of antibiotic prescriptions in hospitalized patients with urinary tract infections (UTIs) within the framework of rational drug use (RDU).
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Key Findings & Data:Materials and Methods: This retrospective descriptive study included 1,097 inpatients diagnosed with UTIs at Yozgat City Hospital between January and December 2023.
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Conclusion & Impact:These findings highlight the urgent need for integrating antibiogram data into clinical decision-making and strengthening antimicrobial stewardship programs to promote rational antibiotic use.
🔬Design:Araştırma Makalesi
📍Scope:2023 Verileri
⚙️Variables:İdrar yolu enfeksiyonları · Antibiyotik direnci · Akılcı ilaç kullanımı

Abstract

Objective: This study aimed to evaluate the distribution of uropathogens, their antibiotic susceptibility patterns, and the appropriateness of antibiotic prescriptions in hospitalized patients with urinary tract infections (UTIs) within the framework of rational drug use (RDU). Materials and Methods: This retrospective descriptive study included 1,097 inpatients diagnosed with UTIs at Yozgat City Hospital between January and December 2023. Microbiological culture results and antibiotic susceptibility profiles were analyzed. Additionally, prescriptions of 378 randomly selected patients were evaluated for compliance with antibiogram results. Statistical analyses were performed using SPSS 23.0. Results: A total of 34 microorganisms were identified, with Escherichia coli (36.95%), Klebsiella pneumoniae (16.88%), and Pseudomonas aeruginosa (9.22%) being the most common. High resistance rates were observed for clindamycin (96.3%), cefoxitin (96.2%), and ampicillin (78.7%). Notably, resistance to commonly used broad-spectrum antibiotics such as ciprofloxacin and ceftriaxone was also high (56.8%). Amikacin (83.7%) and meropenem (62.6%) showed higher susceptibility. Among prescriptions, meropenem (22.8%) was the most frequently used antibiotic. Antibiogram compatibility was 65.2% for E. coli and 32.1% for other microorganisms. Conclusion: A substantial proportion of empirical antibiotic treatments were not aligned with susceptibility results. These findings highlight the urgent need for integrating antibiogram data into clinical decision-making and strengthening antimicrobial stewardship programs to promote rational antibiotic use.

Özet

Amaç: Bu çalışma, rasyonel ilaç kullanımı (RDU) çerçevesinde, idrar yolu enfeksiyonu (İYE) tanısı konmuş yatan hastalarda idrar yolu patojenlerinin dağılımını, antibiyotik duyarlılık profillerini ve antibiyotik reçetelerinin uygunluğunu değerlendirmeyi amaçlamıştır. Gereç ve Yöntemler: Bu retrospektif tanımlayıcı çalışmaya, Ocak-Aralık 2023 tarihleri arasında Yozgat Şehir Hastanesinde İYE tanısı konulan 1.097 yatak hastası dahil edilmiştir. Mikrobiyolojik kültür sonuçları ve antibiyotik duyarlılık profilleri analiz edilmiştir. Ayrıca, rastgele seçilen 378 hastanın reçeteleri, antibiyogram sonuçlarına uygunluk açısından değerlendirilmiştir. İstatistiksel analizler SPSS 23.0 kullanılarak yapılmıştır. Bulgular: Toplam 34 mikroorganizma tanımlanmıştır; bunların en yaygın olanları Escherichia coli (%36,95), Klebsiella pneumoniae (%16,88) ve Pseudomonas aeruginosa (%9,22) idi. Klindamisin (%96,3), sefoxitin (%96,2) ve ampisilin (%78,7) için yüksek direnç oranları gözlendi. Özellikle, siprofloksasin ve seftriakson gibi yaygın olarak kullanılan geniş spektrumlu antibiyotiklere karşı direnç de yüksekti (%56,8). Amikasin (%83,7) ve meropenem (%62,6) daha yüksek duyarlılık gösterdi. Reçeteler arasında meropenem (%22,8) en sık kullanılan antibiyotikti. Antibiyogram uyumu E. coli için %65,2, diğer mikroorganizmalar için %32,1 idi. Sonuç: Ampirik antibiyotik tedavilerinin önemli bir kısmı duyarlılık sonuçlarıyla uyumlu değildi. Bu bulgular, antibiyogram verilerinin klinik karar verme sürecine entegre edilmesinin ve rasyonel antibiyotik kullanımını teşvik etmek için antimikrobiyal yönetim programlarının güçlendirilmesinin acil ihtiyacını vurgulamaktadır.

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Cite This Article

Şahin, M., Şahin, S., Küçük, T. (2026). EVALUATION OF ANTIBIOTIC SUSCEPTIBILITY PATTERNS AND PRESCRIPTION PRACTICES IN URINARY TRACT INFECTIONS FROM A RATIONAL DRUG USE PERSPECTIVE. Bozok Tıp Dergisi, Cilt: 16 Sayı: 3, 433–442. https://doi.org/10.16919/bozoktip.1911648

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