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Journals / Bitlis Eren Üniversitesi Fen Bilimleri Dergisi / 2026 / Volume: 15 Issue: 3

Cytotoxic and Free Radical Scavenging Activities of Turkish Medicinal Plants against Human Lung, Hepatocellular, and Colorectal Carcinoma Cells

Açelya Erikçi(Lokman Hekim Üniversitesi)0000-0001-9149-9510
Murat Kürşat(BİTLİS EREN ÜNİVERSİTESİ)0000-0002-0861-4213
Makbule Beyza Şen(LOKMAN HEKİM ÜNİVERSİTESİ)0000-0003-4015-5595
İbrahim Seyda Uras(AĞRI İBRAHİM ÇEÇEN ÜNİVERSİTESİ)0000-0001-5945-8743
Belma Konuklugil(LOKMAN HEKİM ÜNİVERSİTESİ)0000-0002-4753-0450
Pages
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Publication Date
2026-09-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This study provides the first preliminary evaluation to investigate the antioxidant activity of A. orientale, as well as to evaluate the cytotoxic effects of R. microcalycinum, F. asepala, and D. cachrydifolia on Caco-2, A549, and HepG2 cell lines.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Cancer is a major global health challenge, highlighting the need for new chemotherapeutic and adjunctive agents.
📊
Key Findings & Data:To assess their effects on cancer cell viability, the plant extracts were tested on three different human cancer cell lines: A549, Caco-2, and HepG2.
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Conclusion & Impact:This study provides the first preliminary evaluation to investigate the antioxidant activity of A. orientale, as well as to evaluate the cytotoxic effects of R. microcalycinum, F. asepala, and D. cachrydifolia on Caco-2, A549, and HepG2 cell lines.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Medicinal plants · Turkish flora · Human cancer cell lines

Abstract

Cancer is a major global health challenge, highlighting the need for new chemotherapeutic and adjunctive agents. Turkey’s rich botanical diversity offers a valuable source for exploring bioactive compounds with potential relevance to cancer-related research. This study aims to evaluate the antioxidant activity and preliminary cytotoxic effects of selected plant species as an initial screening approach. Among the species examined, four are members of the Apiaceae family, while the others belong to Lamiaceae, Papaveraceae, and Plantaginaceae families. To assess their effects on cancer cell viability, the plant extracts were tested on three different human cancer cell lines: A549, Caco-2, and HepG2. Zosima absinthifolia, Anarrhinum orientale and Rhabdosciadium microcalycinum showed reduced viability in all tested cancer cell lines. According to the DPPH activity results, it was determined that Diplotaenia cachrydifolia, Ferulago stellata and Salvia pseudeuphratica extracts showed high free radical scavenging activity. This study provides the first preliminary evaluation to investigate the antioxidant activity of A. orientale, as well as to evaluate the cytotoxic effects of R. microcalycinum, F. asepala, and D. cachrydifolia on Caco-2, A549, and HepG2 cell lines.

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Cite This Article

Erikçi, A., Kürşat, M., Şen, M. B., Uras, İ. S., Konuklugil, B. (2026). Cytotoxic and Free Radical Scavenging Activities of Turkish Medicinal Plants against Human Lung, Hepatocellular, and Colorectal Carcinoma Cells. Bitlis Eren Üniversitesi Fen Bilimleri Dergisi, Volume: 15 Issue: 3. https://doi.org/10.17798/bitlisfen.1893162

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