Journals / Batı Karadeniz Tıp Dergisi / 2021 / Cilt: 5 Sayı: 3

The Relationship of Serum Lipid Profile With Preeklampsia Prediction and Newborn Result

Serum Lipid Profilinin Preeklampsi Öngörüsü ve Yenidoğan Sonuçları ile İlişkisi

Selim Gülücü(Tokat Gaziosmanpaşa Üniversitesi)0000-0001-7494-4045
Mehmet Güçlü(İSTANBUL SAĞLIK BAKANLIĞI MARMARA ÜNİVERSİTESİ PENDİK EĞİTİM VE ARAŞTIRMA HASTANESİ)0000-0002-8295-0629
Sebahattin Çelik(BALIKESİR DEVLET HASTANESİ)0000-0002-2631-1603
İlkin Seda Can(CUMHURİYET ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-2029-7281
Canan Soyer Çalışkan(SAMSUN EĞİTİM VE ARAŞTIRMA HASTANESİ)0000-0002-9889-5249
Samettin Çelik(SAMSUN EĞİTİM VE ARAŞTIRMA HASTANESİ)0000-0002-6407-1129
Pages
347–352
Publication Date
2021-12-25
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This suggests that the serum lipid profile may be insufficient to predict the development of PE.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: To investigate the benefit of first trimester lipid profile in predicting preeclampsia and its relationship with neonatal outcomes.
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Key Findings & Data:Material and Methods: Plasma concentrations of cholesterol, triglyceride, HDL, LDL were meausred in 121 women with preeclampsia (PE) and in 99 healthy pregnant women in the first trimester (<12 weeks).There was a comparison between groups with and without PE.
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Conclusion & Impact:This suggests that the serum lipid profile may be insufficient to predict the development of PE.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Preeklampsi · Lipid profili · İlk trimester

Abstract

Aim: To investigate the benefit of first trimester lipid profile in predicting preeclampsia and its relationship with neonatal outcomes. Material and Methods: Plasma concentrations of cholesterol, triglyceride, HDL, LDL were meausred in 121 women with preeclampsia (PE) and in 99 healthy pregnant women in the first trimester (<12 weeks).There was a comparison between groups with and without PE. The relationship between lipid profile of each group and neonatal outcomes was evaluated. Results: There was no significant difference between the groups in gravida and parity numbers. Differences were found between age, body mass index (BMI) measurements, birth weeks, birth weights, and NICU acceptance values. Babies in the PE group had lower mean birth weeks, birth weight and APGAR scores. Babies in the PE group had a higher rate of cesarean delivery. When the laboratory results are examined among the groups; All lipid measurements in the PE group were found to be significantly lower. Conclusion: The serum lipid profile in the first trimester was found to be lower in the PE group compared to the control group. Although low HDL is an expected finding, the others are not expected. This suggests that the serum lipid profile may be insufficient to predict the development of PE.

Özet

Amaç: İlk trimester lipid profilinin preeklampsi öngörüsünde faydasını ve yenidoğan sonuçlarıyla olan ilişkisini araştırmaktır. Gereç ve Yöntemler: Çalışmaya preeklampsi (PE) tanısı almış 121 hasta ve 99 sağlıklı gebe kadın dahil edildi. Çalışma retrospektif olarak dizayn edilmiştir. Hastaların yaş, gravida, parite, vücut kütle indeksi (VKI), doğum şekli, doğum kilosu, APGAR skoru, yenidoğan yoğun bakım ünitesi (YYBÜ) kabulü ve doğum haftası kaydedildi. Laboratuvar analizlerinde ilk trimester (<12 hafta) kolesterol, trigliserid, HDL, LDL düzeyleri tespit edildi. PE’li ve PE’siz iki grup oluşturularak karşılaştırma yapıldı. Her grubun lipid profili ile yenidoğan sonuçları arasındaki ilişki değerlendirildi. Bulgular: Gruplar arasında gravida ve parite sayıları arasında anlamlı fark yoktu. Yaş, VKI ölçümleri, doğum haftaları, doğum kiloları, YYBÜ kabulü değerleri arasında farklılık saptanmadı. PE grubundaki bebeklerin ortalama doğum haftaları, doğum kiloları ve APGAR skorları daha düşüktü. PE grubundaki bebeklerin sezaryan olma oranı daha yüksekti. Grupları arasında laboratuvar sonuçları incelendiğinde; PE grubundaki tüm lipid ölçümleri anlamlı olarak daha düşüktür bulundu. Her iki grupta yenidoğan APGAR skoru ve YYBÜ ihtiyacı ile laboratuvar sonuçları arasında anlamlı bir ilişki saptanmadı (p<0.05). Sonuç: İlk trimesterde bakılan serum lipid profilindeki parametreler PE grubunda kontrol grubuna göre daha düşük bulundu. HDL düşüklüğü beklenen bir bulgu olmakla beraber kolesterol, trigliserid ve LDL düşüklüğü beklenti dışındadır. Sonuçlarımız serum lipid profilinin PE gelişmesini öngörmede yetersiz kalabileceğini düşündürmektedir.

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Cite This Article

Gülücü, S., Güçlü, M., Çelik, S., Can, İ. S., Çalışkan, C. S., Çelik, S. (2021). The Relationship of Serum Lipid Profile With Preeklampsia Prediction and Newborn Result. Batı Karadeniz Tıp Dergisi, Cilt: 5 Sayı: 3, 347–352. https://doi.org/10.29058/mjwbs.871805

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