Journals / Batı Karadeniz Tıp Dergisi / 2022 / Cilt: 6 Sayı: 3

Comparison of Clinicopathological Features in Differentiated Thyroid Carcinomas at 55 Age Cut-Off Point: A Single Center Experience

Diferansiye Tiroid Karsinomlarında 55 Yaş Kesim Noktasında Klinikopatolojik Özelliklerin Karşılaştırılması: Tek Merkez Deneyimi

Nagihan Beştepe(Sağlık Bakanlığı Ankara Şehir Hastanesi)0000-0002-4998-1781
Hüsniye Başer(ANKARA YILDIRIM BEYAZIT ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-6371-2959
Ayşegül Aksoy Altınboğa(ANKARA YILDIRIM BEYAZIT ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-1484-7619
Abdussamed Yalçın(ANKARA YILDIRIM BEYAZIT ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-9745-2502
Oya Topaloğlu(ANKARA YILDIRIM BEYAZIT ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-2501-935X
Reyhan Ersoy(ANKARA YILDIRIM BEYAZIT ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-7437-1176
Bekir Çakır(ANKARA YILDIRIM BEYAZIT ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-7526-8827
Pages
274–282
Publication Date
2022-12-27
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: DTC in patients ≥55 years old is associated with larger tumors, greater ETE, and greater capsular invasion compared to patients <55 years old.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: The incidence of differentiated thyroid cancer (DTC) has been increasing rapidly in recent years.
📊
Key Findings & Data:The American Joint Committee on Cancer (AJCC) staging system currently uses 55 years of age as the cutoff point.
💡
Conclusion & Impact:Conclusion: DTC in patients ≥55 years old is associated with larger tumors, greater ETE, and greater capsular invasion compared to patients <55 years old.
🔬Design:Klinik Araştırma
📍Scope:Comprehensive Sample
⚙️Variables:Diferansiye Tiroid Karsinomu · Klinikopatolojik özellikler · Yaş

Abstract

Objectives: The incidence of differentiated thyroid cancer (DTC) has been increasing rapidly in recent years. Patient age at diagnosis is a good prognostic factor for thyroid cancer. DTC is the only malignancy that includes age as part of its staging system. The American Joint Committee on Cancer (AJCC) staging system currently uses 55 years of age as the cutoff point. In this study, we aimed to compare the clinicopathological features of DTC in patients 55 years old (p=0.009). Extrathyroidal extension (ETE) was detected in 8.42% of <55 years old patients and 12.79% of patients ≥55 years old (p=0.011). Capsular invasion was detected in 19.11% of <55 years old patients and 23.24% of patients ≥55 years old (p=0.032). The rate of chronic lymphocytic thyroiditis in the <55 years old patients was higher than in the ≥55 years old patients (p<0.001). Lymphatic invasion, vascular invasion, lymph node metastasis, distant metastasis, persistence, and recurrence rates were similar. Conclusion: DTC in patients ≥55 years old is associated with larger tumors, greater ETE, and greater capsular invasion compared to patients <55 years old.

Özet

Amaç: Diferansiye tiroid kanseri (DTC) insidansı son yıllarda hızla artmaktadır. Tanı anındaki hasta yaşı, tiroid kanseri sağkalımı için iyi bir prognostik faktördür. DTC, evreleme sisteminin bir parçası olarak yaşı içeren tek malignitedir. Amerikan Ortak Kanser Komitesi (AJCC) evreleme sistemi şu anda kesim noktası olarak 55 yaşı kullanmaktadır. Bu çalışmada, serimizdeki 55 yaş hastalarda 12,65±12,72 mm idi (p=0,009). <55 yaş hastaların %8,42'sinde ve ≥55 yaş hastaların %12,79'unda ekstratiroidal yayılım (ETE) saptandı (p=0.011). <55 yaş hastaların %19.11'inde ve ≥55 yaş hastaların %23.24'ünde kapsüler invazyon saptandı (p=0.032). <55 yaş hastalarda kronik lenfositik tiroidit oranı ≥55 yaş hastalara göre daha yüksekti (p<0,001). Lenfatik invazyon, vasküler invazyon, lenf nodu metastazı, uzak metastaz, persistans ve rekürrens oranları benzerdi. Sonuç: DTC'li ≥55 yaş hastalarda, <55 yaşındaki hastalara kıyasla daha büyük tümörler, daha fazla ekstratiroidal yayılım ve daha fazla kapsüler invazyon mevcuttur.

🔖

Cite This Article

Beştepe, N., Başer, H., Altınboğa, A. A., Yalçın, A., Topaloğlu, O., Ersoy, R., Çakır, B. (2022). Comparison of Clinicopathological Features in Differentiated Thyroid Carcinomas at 55 Age Cut-Off Point: A Single Center Experience. Batı Karadeniz Tıp Dergisi, Cilt: 6 Sayı: 3, 274–282. https://doi.org/10.29058/mjwbs.1201993

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (4)

  1. Cramer JD, Fu P, Harth KC, Margevicius S, Wilhelm SM. Analysis of the rising incidence of thyroid cancer using the Surveillance, Epidemiology and End Results national cancer data registry. Surgery 2010;148(6):1147-1152.
  2. Haymart MR. Understanding the relationship between age and thyroid cancer. Oncologist 2009;14(3):216-221.
  3. Orosco RK, Hussain T, Brumund KT, Oh DK, Chang DC, Bouvet M. Analysis of age and disease status as predictors of thyroid cancer-specific mortality using the Surveillance, Epidemiology, and End Results database. Thyroid 2015;25(1):125-132.
  4. Oyer SL, Smith VA, Lentsch EJ. Reevaluating the prognostic significance of age in differentiated thyroid cancer. Otolaryngol Head Neck Surg 2012;147(2):221-226.