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Journals / Batı Karadeniz Tıp Dergisi / 2026 / Cilt: 9 Sayı: 2

Dopamine-Secreting Head and Neck Paragangliomas: Literature Review and A Case Report

Dopamin Sekrete Eden Baş ve Boyun Paragangliomaları: Literatür İncelemesi ve Olgu Sunumu

Deniz Baklacı(ZONGULDAK BÜLENT ECEVİT ÜNİVERSİTESİ)0000-0001-8449-4965
Duygu Erdem(ZONGULDAK BÜLENT ECEVİT ÜNİVERSİTESİ)0000-0002-7973-2719
Seda Nur Saka(ZONGULDAK BÜLENT ECEVİT ÜNİVERSİTESİ)0009-0002-2135-0504
Gökhan Furkan Kılıç(ZONGULDAK BÜLENT ECEVİT ÜNİVERSİTESİ)0000-0003-3975-3547
Aleyna Şivetoğlu(ZONGULDAK BÜLENT ECEVİT ÜNİVERSİTESİ)0009-0006-7262-181X
Pages
135–141
Publication Date
2025-08-31
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Dopamine measurements may be useful for the diagnosis and follow-up of these tumors.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:This study aims to review the cases of dopamine-secreting paragangliomas of the head and neck in the literature and to present a patient diagnosed with a jugular and carotid body paraganglioma secreting only dopamine.
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Key Findings & Data:Between 1983 and 2024, 16 cases of predominantly dopamine-secreting paragangliomas located in the head and neck region were reviewed in the literature and one case is presented to contribute to the existing knowledge.
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Conclusion & Impact:Dopamine measurements may be useful for the diagnosis and follow-up of these tumors.
🔬Design:Review & Systematic Survey
📍Scope:2024 Verileri
⚙️Variables:Baş ve boyun · dopamin · paraganglioma

Abstract

This study aims to review the cases of dopamine-secreting paragangliomas of the head and neck in the literature and to present a patient diagnosed with a jugular and carotid body paraganglioma secreting only dopamine. It is considered that dopamine excess is common in head and neck paragangliomas and dopamine measurement may be useful in the follow-up of patients. Between 1983 and 2024, 16 cases of predominantly dopamine-secreting paragangliomas located in the head and neck region were reviewed in the literature and one case is presented to contribute to the existing knowledge. Hypertension is the most common symptom in dopamine-secreting paragangliomas of the head and neck, followed by hearing loss, dysphagia, dysphonia and tinnitus. The median age was 46.3 years and the male to female ratio was 1.6:1. Treatment modalities included surgery in 10 cases, radiotherapy in 2 cases, conservative treatment in 1 case and no treatment record was available in 3 cases. In our case, the patient presented with hypertension, hearing loss, dysphonia, tinnitus and facial paralysis and was treated with radiotherapy. Dopamine-secreting head and neck paragangliomas are usually symptomatic due to compression, and there may be various morbidities associated with the disease at the time of diagnosis. Dopamine measurements may be useful for the diagnosis and follow-up of these tumors.

Özet

Bu çalışmanın amacı, literatürde baş boyunda dopamin salgılayan paraganglioma olgularını incelemek ve yalnızca dopamin salgılayan juguler ve karotis cisim paraganglioma tanılı bir hastayı sunmaktır. Dopamin fazlalığının baş boyun paragangliomalarında sık görüldüğü ve dopamin ölçümünün hastaların takibinde faydalı olabileceği düşünülmektedir 1983-2024 yılları arasında literatürde baş-boyun bölgesinde yer alan ve ağırlıklı olarak dopamin salgılayan 16 paraganglioma olgusu incelenmiş ve bir olgu sunularak literatüre katkıda bulunulmuştur. Baş boyunda dopamin salgılayan paragangliomalarda en sık görülen semptom hipertansiyon olarak bulunmuş; bunu işitme kaybı, disfaji, disfoni, tinnitus izlemiştir. Olguların medyan yaşı 46,3 olup, erkek-kadın oranı 1,6:1’dir. Tedavi yöntemleri arasında 10 olguda cerrahi, 2 olguda radyoterapi, 1 olguda konservatif tedavi uygulanmış, 3 olguda tedavi kayıtlarına ulaşılamamıştır. Olgumuzda da hipertansiyon, işitme kaybı, disfoni, tinnitus ve fasiyal paralizi mevcuttu ve radyoterapi tedavisi aldı. Dopamin salgılayan baş boyun paragangliomaları genellikle basıya bağlı semptom verir, tanı anında hastalığa bağlı çeşitli morbiditeler olabilir. Dopamin ölçümleri, bu tümörlerin tanı ve takibi için faydalı olabilir.

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Cite This Article

Baklacı, D., Erdem, D., Saka, S. N., Kılıç, G. F., Şivetoğlu, A. (2025). Dopamine-Secreting Head and Neck Paragangliomas: Literature Review and A Case Report. Batı Karadeniz Tıp Dergisi, Cilt: 9 Sayı: 2, 135–141. https://doi.org/10.29058/mjwbs.1598103

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