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Journals / Batı Karadeniz Tıp Dergisi / 2026 / Cilt: 10 Sayı: 2

Atorvastatin's protective effect against amikacin-induced ototoxicity: An experimental study in rats

Atorvastatin’in amikasin kaynaklı ototoksisiteye karşı koruyucu etkisi: Sıçanlarda deneysel bir çalışma

Müyeser Burcu Saygılı Kaya(Private Clinic, Gaziantep, Türkiye)0000-0002-6269-1252
Deniz Baklacı(Zonguldak Bülent Ecevit University, Department of Otolaryngology-Head and Neck Surgery, Zonguldak, Türkiye)0000-0001-8449-4965
Şeyda Akbal Çufalı(Ankara Bilkent City Hospital, Department of Otorhinolaryngology-Head and Neck Surgery, Ankara, Türkiye)0000-0003-4554-9278
Gökhan Furkan Kılıç(Zonguldak Bülent Ecevit University, Department of Otolaryngology-Head and Neck Surgery, Zonguldak, Türkiye)0000-0003-3975-3547
Hasan Şahin(Güven Hospital, Department of Audiology, Ankara, Türkiye)0000-0003-4973-1739
Rauf Oguzhan Kum(Güven Hospital, Department of Otolaryngology-Head and Neck Surgery, Ankara, Türkiye)0000-0002-9639-0204
Müge Özcan(Private Clinic, Ankara, Türkiye)0000-0003-2384-3564
Pages
321–328
Publication Date
2026-08-31
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Further well-designed studies are required to confirm the clinical relevance of these results and to explore the potential of atorvastatin as a strategy to reduce the risk of hearing loss associated with aminoglycoside therapy.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Aminoglycoside antibiotics such as amikacin can cause irreversible hearing loss due to ototoxicity.
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Key Findings & Data:Material and Methods: Twenty Wistar Albino rats were divided into four groups: control, atorvastatin (10 mg/kg/day), amikacin (600 mg/kg/day), and amikacin + statins.
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Conclusion & Impact:Further well-designed studies are required to confirm the clinical relevance of these results and to explore the potential of atorvastatin as a strategy to reduce the risk of hearing loss associated with aminoglycoside therapy.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Amikasin · atorvastatin · Distorsiyon Ürünü Otoakustik Emisyon (DPOAE)

Abstract

Aim: Aminoglycoside antibiotics such as amikacin can cause irreversible hearing loss due to ototoxicity. This study aimed to investigate the potential protective effects of atorvastatin against amikacin-induced ototoxicity in a rat model. Material and Methods: Twenty Wistar Albino rats were divided into four groups: control, atorvastatin (10 mg/kg/day), amikacin (600 mg/kg/day), and amikacin + statins. Auditory function was evaluated using Auditory Brainstem Response (ABR) and Distortion Product Otoacoustic Emission (DPOAE) tests on days 0, 7, and 14. Results: The amikacin group showed significant hearing loss on days 7 and 14 compared with baseline (p < 0.001), whereas the amikacin + statin group had significantly better hearing thresholds than the amikacin group (p < 0.001). The DPOAE values decreased significantly in the amikacin and amikacin + statin groups, especially at high frequencies (4000-6000 Hz) on days 7 and 14 (p < 0.001). However, this decrease was less pronounced in the amikacin + statin group. No significant changes in hearing were observed in the control or statin groups. Conclusion: These findings suggest that atorvastatin may attenuate amikacin-induced ototoxicity, possibly through its antioxidant and anti-inflammatory properties. Further well-designed studies are required to confirm the clinical relevance of these results and to explore the potential of atorvastatin as a strategy to reduce the risk of hearing loss associated with aminoglycoside therapy.

Özet

Amaç: Amikasin gibi aminoglikozid antibiyotikler, ototoksisite nedeniyle geri dönüşümsüz işitme kaybına neden olabilir. Bu çalışma, sıçan modelinde atorvastatinin amikasin kaynaklı ototoksisiteye karşı potansiyel koruyucu etkilerini araştırmayı amaçlamıştır. Gereç ve Yöntemler: Yirmi Wistar Albino sıçan dört gruba ayrıldı: kontrol, atorvastatin (10 mg/kg/gün), amikasin (600 mg/kg/gün) ve amikasin + statinler. İşitsel fonksiyon, 0., 7. ve 14. günlerde İşitsel Beyin Sapı Yanıtı (ABR) ve Distorsiyon Ürün Otoakustik Emisyon (DPOAE) testleri kullanılarak değerlendirildi. Bulgular: Amikasin grubu, başlangıç değerine kıyasla 7. ve 14. günlerde önemli ölçüde işitme kaybı gösterirken (p < 0,001), amikasin + statin grubu, amikasin grubuna kıyasla önemli ölçüde daha iyi işitme eşiklerine sahipti (p < 0,001). DPOAE değerleri, amikasin ve amikasin + statin gruplarında, özellikle 7. ve 14. günlerde yüksek frekanslarda (4000-6000 Hz) önemli ölçüde azaldı (p < 0,001). Ancak, bu azalma amikasin + statin grubunda daha az belirgindi. Kontrol veya statin gruplarında işitmede önemli bir değişiklik gözlenmedi. Sonuç: Bu bulgular, atorvastatinin muhtemelen antioksidan ve antienflamatuar özellikleri sayesinde amikasin kaynaklı ototoksisiteyi azaltabileceğini düşündürmektedir. Bu sonuçların klinik geçerliliğini doğrulamak ve aminoglikozid tedavisiyle ilişkili işitme kaybı riskini azaltmak için yeni bir strateji olarak atorvastatinin potansiyelini araştırmak için daha fazla araştırma yapılması gerekmektedir.

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Cite This Article

Kaya, M. B. S., Baklacı, D., Çufalı, Ş. A., Kılıç, G. F., Şahin, H., Kum, R. O., Özcan, M. (2026). Atorvastatin's protective effect against amikacin-induced ototoxicity: An experimental study in rats. Batı Karadeniz Tıp Dergisi, Cilt: 10 Sayı: 2, 321–328. https://doi.org/10.29058/mjwbs.1879140

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