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Journals / Balkan Medical Journal / 2026 / Cilt: 32 Sayı: 1

Phenotypes and Genotypes of Macrolide-Resistant Streptococcus Pneumoniae

Leyla Sirekbasan
Nevriye Gönüllü
Serhat Sirekbasan
Mert Kuşkucu
Kenan Midilli
Pages
84–88
Publication Date
2015-01-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion_ Increased positivity rates for both resistance genes have also been reported from other hospitals in Turkey, but this is the first study from Turkey showing the clonal dissemination of both resistance genes_

📌 3 Key Takeaways

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Objective & Hypothesis:_Macrolide resistance in Streptococcus pneumoniae (S. pneumoniae) is a worldwide problem.
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Key Findings & Data:Methods_ 80 non-duplicate S. pneumoniae strains were analyzed by polymerase chain reaction for both the erm (B) and mef (A) genes.
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Conclusion & Impact:Conclusion_ Increased positivity rates for both resistance genes have also been reported from other hospitals in Turkey, but this is the first study from Turkey showing the clonal dissemination of both resistance genes_
🔬Design:Makale
📍Scope:Comprehensive Sample
⚙️Variables:erm (B) · BOX-PCR · Macrolide resistance

Abstract

_Macrolide resistance in Streptococcus pneumoniae (S. pneumoniae) is a worldwide problem. Aims_ The aim of this work was to analyze the phenotypes, genotypes, and clonal relatedness among macrolide-resistant S. pneumoniae strains isolated from various clinical specimens in our hospital. Study Design_ Cross-sectional study. Methods_ 80 non-duplicate S. pneumoniae strains were analyzed by polymerase chain reaction for both the erm (B) and mef (A) genes. Results_ Macrolide resistance was observed in 22.5% (18 strains) of strains. Two (11.2%) isolates possessed mef (A), eight possessed erm (B) (44.4%) and eight strains (44.4%) were positive for both erm (B) and mef (A) genes. Although BOX-PCR of 18 macrolide-resistant strains revealed 11 band patterns, they clustered as seven clones with a genetic distance _10% to each other. Eight isolates possessed both erm (B) and mef (A) genes and belonged to a single clone (44.44% of all macrolide-resistant strains). Conclusion_ Increased positivity rates for both resistance genes have also been reported from other hospitals in Turkey, but this is the first study from Turkey showing the clonal dissemination of both resistance genes_

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Cite This Article

Sirekbasan, L., Gönüllü, N., Sirekbasan, S., Kuşkucu, M., Midilli, K. (2015). Phenotypes and Genotypes of Macrolide-Resistant Streptococcus Pneumoniae. Balkan Medical Journal, Cilt: 32 Sayı: 1, 84–88. https://ajindex.com/articles/1373881

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References (6)

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