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Journals / Ankara Üniversitesi Veteriner Fakültesi Dergisi / 2026 / Volume: 57 Issue: 2

Determine of the antioxidant levels and some biochemical parameters on infected with ascaridiosis and treated dogs

Askaridiozisli ve tedavi edilmiş köpeklerde antioksidan düzeylerinin ve bazı biyokimyasal parametrelerinin incelenmesi

Esma Kozan(Afyon Kocatepe Üniversitesi Veteriner Fakültesi Parazitoloji Anabilim Dalı)
Gülcan Avcı(Afyon Kocatepe Üniversitesi Veteriner Fakültesi Biyokimya Anabilim Dalı)
Feride Kırcalı Sevimli(Afyon Kocatepe Üniversitesi Veteriner Fakültesi Parazitoloji Anabilim Dalı)
Fatih Mehmet Birdane(Afyon Kocatepe Üniversitesi Veteriner Fakültesi İç Hastalıkları Anabilim Dalı.)
Mustafa Köse(Afyon Kocatepe Üniversitesi Veteriner Fakültesi Parazitoloji Anabilim Dalı)
Pages
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Publication Date
2010-06-01
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Treatment with suitable an anthelmintic drug this helminth parasites is effective to alleviate the oxidative damage

📌 3 Key Takeaways

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Objective & Hypothesis:This study was performed to determine the antioxidant levels and some biochemical parameters on natural infected dogs with Toxocara canis and/or T.leonina and treated dogs.
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Key Findings & Data:The dogs naturally infected with Toxocara canis and/or Toxascaris leonina were allocated in two groups as treated (n=18) and positive control (n=6), whereas dogs, not infected with helminth, were kept as a negative control (n=6).
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Conclusion & Impact:Treatment with suitable an anthelmintic drug this helminth parasites is effective to alleviate the oxidative damage
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Antioxidant activity · dog · lipid peroxidation

Abstract

This study was performed to determine the antioxidant levels and some biochemical parameters on natural infected dogs with Toxocara canis and/or T.leonina and treated dogs. In this study three to six years old and different sexes thirty dogs were used. The dogs naturally infected with Toxocara canis and/or Toxascaris leonina were allocated in two groups as treated (n=18) and positive control (n=6), whereas dogs, not infected with helminth, were kept as a negative control (n=6). Eprinomectin with 100 µg/kg dose were orally used in treated group, while dogs in negative and positive were not treated with any drugs. Prior to treatment blood and faeces samples were collected from all dogs and sample collection was continued on day 7 and day 15 posttreatment. Blood reduced glutathione (GSH), plasma malondialdehyde (MDA), antioxidant activity (AOA), glucose, total protein, urea, creatinin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transferase (GGT) levels were detected. Eggs per gram faeces (EPG) was performed and the severity of infection was detected in the infected dogs. In this study, the total protein and antioxidant activity was alleviated while plasma creatinin and lipid peroxidation levels were increased in the dogs natural infected with T. canis and/or T. leonina. Treatment with suitable an anthelmintic drug this helminth parasites is effective to alleviate the oxidative damage

Özet

Bu çalışma Toxocara canis ve/veya Toxascaris leonina ile doğal enfekte ve tedavi edilmiş köpeklerde antioksidan düzeylerinin ve bazı biyokimyasal parametrelerin belirlenmesi amacıyla yapılmıştır. Çalışma 3-6 yaşlı ve farklı cinsiyette toplam 30 sokak köpeği üzerinde yürütülmüştür. Toxocara canis ve/veya Toxascaris leonina ile doğal enfekte olduğu tespit edilen köpekler tedavi (n=18) ve pozitif kontrol (n=6) grubu olarak ayrılmış ve herhangi bir helmint enfeksiyonu tespit edilmeyen köpekler negatif kontrol (n=6) grubu olarak kullanılmıştır. Tedavi grubundaki köpeklere Eprinomectin 100 µg/kg oral uygulanmış, negatif ve pozitif kontrol gruplarındaki köpeklere herhangi bir ilaç uygulaması yapılmamıştır. Tüm gruplardan tedavi öncesinden başlanarak tedavi sonrası 7. ve 15. günlerde kan ve dışkı örnekleri düzenli olarak alınmıştır. Tam kan indirgenmiş glutasyon (GSH), plazma malondialdehit (MDA), antioksidan aktivite (AOA), glikoz, total protein, üre, kreatinin, aspartat aminotransferaz (AST), alanin aminotransferaz (ALT), gama-glutamil transferaz (GGT) düzeyleri ile enfekte köpeklere gram dışkı yumurta sayımı (EPG) yapılarak enfeksiyon şiddeti belirlenmiştir. Toxocara canis ve/veya Toxascaris leonina ile doğal enfekte köpeklerde kreatinin ve lipid peroksidasyonu artarken, total protein ve antioksidan aktivitenin düştüğü ve bu helmintlerin uygun bir antelmentikle tedavi edilmesinin, oluşan oksidatif hasarı hafifletmede etkili olduğu tespit edilmiştir

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Cite This Article

Kozan, E., Avcı, G., Sevimli, F. K., Birdane, F. M., Köse, M. (2010). Determine of the antioxidant levels and some biochemical parameters on infected with ascaridiosis and treated dogs. Ankara Üniversitesi Veteriner Fakültesi Dergisi, Volume: 57 Issue: 2. https://doi.org/10.1501/Vetfak_0000002317

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