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Journals / Ankara Üniversitesi Veteriner Fakültesi Dergisi / 2026 / Volume: 62 Issue: 3

Investigation of some veterinary drug residues in sea water, sediment, and wild fishes captured around fish farms in the Aegean Sea: Oxytetracyline, ivermectin and emamectin

Ege Denizinde balık çiftlikleri etrafında avlanan doğal ortam balıkları ile çevredeki su ve sedimentin bazı veteriner ilaç kalıntıları yönünden incelenmesi: Oksitetrasiklin, ivermektin ve emamektin

Emine Baydan(Ankara University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Ankara)
Sezai Kaya(Ankara University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Ankara)
Haşmet Çağırgan(Ege University, Faculty of Fisheries, Department of Aquaculture, Izmir)
Ebru Yıldırım(Kırıkkale University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Kırıkkale, Turkey)
Levent Altıntaş(Ankara University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Ankara)
Begüm Yurdakök(Ankara University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Ankara)
Hüsamettin Ekici(Kırıkkale University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Kırıkkale, Turkey)
Farah Gönül Aydın(Ankara University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Ankara)
Aslı Gül Küçükosmanoğlu(Ankara University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Ankara)
Pages
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Publication Date
2015-09-01
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In order to understand the possible risk of veterinary antibiotics, especially for low dose accumulation, to the ecosystem for sustainable aquaculture, conduction of more screening analysis with expanded possible matrices would be beneficial

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Veterinary drug residues and their metabolites in food are regularly investigated by local authorities; however their fate in the environment is still unknown.
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Key Findings & Data:Despite the importance of the aquaculture industry and the widespread use of antibiotics; limited scientific information regarding their residue in natural fish, sediment and sea water are available in TURKEY.
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Conclusion & Impact:In order to understand the possible risk of veterinary antibiotics, especially for low dose accumulation, to the ecosystem for sustainable aquaculture, conduction of more screening analysis with expanded possible matrices would be beneficial
🔬Design:Lab & Field Experiment
📍Scope:Comprehensive Sample
⚙️Variables:Aegean Sea · emamectin · HPLC

Abstract

Veterinary drug residues and their metabolites in food are regularly investigated by local authorities; however their fate in the environment is still unknown. Despite the importance of the aquaculture industry and the widespread use of antibiotics; limited scientific information regarding their residue in natural fish, sediment and sea water are available in TURKEY. The current study; which is the first study in this area, was undertaken to determine the oxytetracycline (OTC), ivermectin (IVM) and emamectin benzoate (EMA) residues from samples of wild fishes (Oblada melanura, Mullus barbatus), sea water and sediment collected in four different months, caught around the fish cages near Salihli Island in Bodrum, Aegean Sea. Samples were analyzed by High Pressure Liquid Chromatography (HPLC) followed by the validation for each matrix. No residues were found to be above the Limit of detection (LOD) levels of the validated methods in the screened samples. In order to understand the possible risk of veterinary antibiotics, especially for low dose accumulation, to the ecosystem for sustainable aquaculture, conduction of more screening analysis with expanded possible matrices would be beneficial

Özet

Besinlerdeki ilaç ve metabolitlerinin kalıntıları ilgili yerel makamlar tarafından düzenli olarak araştırılmaktadır; ancak bu kalıntıların çevredeki akıbeti bilinmemektedir. Akvakültür endüstrisinin giderek artan önemi ve antibiyotiklerin bu endüstri ile birlikte kullanımının giderek yaygınlaşmasına rağmen doğal balık, sediment ve deniz suyu kalıntıları ile ilgili araştırmalar Türkiye’de sınırlıdır. Bu araştırmada oksitetrasiklin, ivermektin ve emamektin benzoat kalıntıları; ilaç kullanımının daha fazla olduğu dört ay içerisinde, Ege Denizi, Bodrum, Salihli Adası çevresindeki balık çiftlikleri etrafından avlanan doğal ortam balıkları (Oblada melanura, Mullus barbatus), deniz suyu ve sediment örneklerinde Yüksek Basınçlı Sıvı Kromatografisi (YBSK) yöntemi kullanılarak ve her bir matriksin validasyonunu takiben araştırıldı. Numunelerde, valide edilmiş metodlardaki tespit limiti üzerinde herhangi bir kalıntıya rastlanmadı. Akvakültürde kullanılan veteriner antibiyotiklerinin ekosistem üzerinde özellikle düşük dozlarda akümülasyona bağlı oluşabilecek potansiyel risklerinin değerlendirilebilmesi için, farklı analitlerde tarama testlerinin yaygınlaştırılması ve arttırılması yararlı olacaktır

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Cite This Article

Baydan, E., Kaya, S., Çağırgan, H., Yıldırım, E., Altıntaş, L., Yurdakök, B., Ekici, H., Aydın, F. G., Küçükosmanoğlu, A. G. (2015). Investigation of some veterinary drug residues in sea water, sediment, and wild fishes captured around fish farms in the Aegean Sea: Oxytetracyline, ivermectin and emamectin. Ankara Üniversitesi Veteriner Fakültesi Dergisi, Volume: 62 Issue: 3. https://doi.org/10.1501/Vetfak_0000002676

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