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Journals / Ankara Üniversitesi Veteriner Fakültesi Dergisi / 2026 / Volume: 67 Issue: 1

Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats

Ali Kumandaş(KIRIKKALE UNIVERSITY, FACULTY OF VETERINARY MEDICINE, DEPARTMENT OF SURGERY)0000-0002-7679-2126
Birkan Karslı(KIRIKKALE UNIVERSITY, FACULTY OF VETERINARY MEDICINE, DEPARTMENT OF SURGERY)0000-0003-4208-3134
Aytül Kürüm(KIRIKKALE UNIVERSITY, FACULTY OF VETERINARY MEDICINE, DEPARTMENT OF HISTOLOGY)0000-0002-0170-0231
Miyase Çınar(KIRIKKALE UNIVERSITY, FACULTY OF VETERINARY MEDICINE, DEPARTMENT OF BIOCHEMISTRY)0000-0003-3806-9938
Ertuğrul Elma(KIRIKKALE UNIVERSITY, FACULTY OF VETERINARY MEDICINE, DEPARTMENT OF SURGERY)0000-0001-8795-6512
Pages
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Publication Date
2019-12-26
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Consequently, zinc-silver group has differed positively in terms of biochemical and biomechanical and histological aspects compared to other groups for wound healing and oxidative stress.

📌 3 Key Takeaways

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Objective & Hypothesis:The present study was undertaken to evaluate of Nigella sativa oil (NSO) and zinc-silver cream in a rat model of wound healing by means of clinical appearance, histopathology, oxidative stress parameters, and biomechanical tests.
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Key Findings & Data:Group 1 served as a control having wound.
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Conclusion & Impact:Consequently, zinc-silver group has differed positively in terms of biochemical and biomechanical and histological aspects compared to other groups for wound healing and oxidative stress.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Nigella sativa oil · Oxidative stress · rat

Abstract

The present study was undertaken to evaluate of Nigella sativa oil (NSO) and zinc-silver cream in a rat model of wound healing by means of clinical appearance, histopathology, oxidative stress parameters, and biomechanical tests. The rats were divided into three groups, each having twenty animals. Group 1 served as a control having wound. Other two groups received either NS oil or zinc-silver cream in addition to the wound. The study was initiated after the animals rested for 2 weeks for acclimation. Blood samples were collected from 10 randomly selected animals from each group at days 0, 3, 7 and 14 for oxidative stress measurements. Differences among groups for blood lipid peroxidation and antioxidant values were determined with respect to biochemical oxidative stress results (P<0.01). Wound sites of 10 animals from each group were allocated for histopathological examinations, and those of the remaining 10 animals from each group were used in biomechanical testing . Histopathological examination revealed that epithelization occurred in all groups. Inflammatory response with an intensive vascularization was present in the samples of the silver group (P<0.01). Consequently, zinc-silver group has differed positively in terms of biochemical and biomechanical and histological aspects compared to other groups for wound healing and oxidative stress.

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Cite This Article

Kumandaş, A., Karslı, B., Kürüm, A., Çınar, M., Elma, E. (2019). Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi, Volume: 67 Issue: 1. https://doi.org/10.33988/auvfd.563491

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