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Journals / Ankara Üniversitesi Veteriner Fakültesi Dergisi / 2026 / Volume: 71 Issue: 2

Anencephaly, bifid tongue, and cleft palate in a Pomeranian dog: GFAP and NeuN immunoreactivities

Özkan Yavaş(Bursa Uludağ Üniversitesi)0000-0001-9811-9920
Senem Esin Yavaş(BURSA ULUDAG UNIVERSITY)0000-0002-6949-1210
Doruk Başar(BURSA ULUDAG UNIVERSITY)0000-0001-6231-0424
Zehra Avcı(BURSA ULUDAG UNIVERSITY)0000-0003-1853-4679
Aysun Sarıçetin(BURSA ULUDAG UNIVERSITY)0000-0002-8290-8201
Elif Rana Yıldız(BURSA ULUDAG UNIVERSITY)0000-0003-2370-3721
Semiha Ersoy(BURSA ULUDAG UNIVERSITY)0000-0002-6419-0304
Özgür Özyiğit(BURSA ULUDAG UNIVERSITY)0000-0003-0682-8127
Pages
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Publication Date
2024-04-01
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

To the best of our knowledge, this represents the first description of a dog with anencephaly, bifid tongue and cleft palate.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Anencephaly is a congenital disease manifesting with the absence of the brain due to the failure of the cranial part of the neural tube to close during the embryonic stage.
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Key Findings & Data:A stillborn puppy of a 2-year old female Pomeranian dog is examined in this case.
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Conclusion & Impact:To the best of our knowledge, this represents the first description of a dog with anencephaly, bifid tongue and cleft palate.
🔬Design:Case Report
📍Scope:Comprehensive Sample
⚙️Variables:anencephaly · bifid tongue · cleft palate

Abstract

Anencephaly is a congenital disease manifesting with the absence of the brain due to the failure of the cranial part of the neural tube to close during the embryonic stage. The disease may be accompanied by other anomalies and usually results in premature death. A stillborn puppy of a 2-year old female Pomeranian dog is examined in this case. The lack of brain tissue and accompanying abnormal skull formation was noted macroscopically. The eyes were protruding out of their normal position (protrusion), and a bifid tongue together with a secondary cleft palate was present. On serial sections stained with Haematoxylin-Eosin, only the medulla spinalis among the central nervous system structures could be inspected microscopically. Immunohistochemistry staining revealed GFAP immunoreactivity in the astrocytic glial cells. NeuN immunoreactivity was detected in the neurons in the medulla spinalis and spinal ganglions. Incomplete retinal layers were observed on the eye sections stained with Haematoxylin-Eosin and NeuN. The case was concluded to be coherent with skull and nervous system congenital malformations rarely observed in dogs. To the best of our knowledge, this represents the first description of a dog with anencephaly, bifid tongue and cleft palate.

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Cite This Article

Yavaş, Ö., Yavaş, S. E., Başar, D., Avcı, Z., Sarıçetin, A., Yıldız, E. R., Ersoy, S., Özyiğit, Ö. (2024). Anencephaly, bifid tongue, and cleft palate in a Pomeranian dog: GFAP and NeuN immunoreactivities. Ankara Üniversitesi Veteriner Fakültesi Dergisi, Volume: 71 Issue: 2. https://doi.org/10.33988/auvfd.1141283

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References (25)

  1. Aiello SE (2016): The Merck Veterinary Manuel. Merck&CO, Kenilworth, NJ, USA.
  2. Chow RL, Lang RA (2001): Early eye development in vertebrates. Annu Rev Cell Dev Biol, 17, 255–296.
  3. Copp AJ, Greene NDE (2012): Neural tube defects-disorders of neurulation and related embryonic processes. Dev Biol, 2, 213-227.
  4. Elwood JM, Colquhoun TA (1997): Observations on the prevention of cleft palate in dogs by folic acid and potential relevance to humans. N Z Vet J, 45, 254–256.
  5. Farmand M, Stohler T (1990): The median cleft of the lower lip and mandible and its surgical correction in a donkey. Equine Vet J, 22, 298-301.
  6. Hilder L (2016): Neural tube defects in Australia 2007-2011: before and after implementation of mandatory folic acid fortification standard. In: Health Do, Editor. Canberra, Australia, Department of Health.
  7. Hiredfar M, Bakhshaee M, Shojaeian R, et al (2015): Accessory tongue: Classification and report of a case. Int J Pediatr Otorhinolaryngol, 79, 1175-1179.
  8. Huisinga M, Reinacher M, Nagel S, et al (2010): Anencephaly in a German Shepherd Dog. Vet Path, 47, 948-951.
  9. Lee JY, Zainal HM, Mat Zain MAB (2019): Bifid Tongue and Cleft Palate With and Without a Tessier 30 Facial Cleft: Cases of Rare Congenital Anomalies and a Review of Management and Literature. The Cleft Palate-Craniofacial J, 1-6.
  10. Lopes SP, Helayel MA, Cunha IM, et al (2019): Reduction Glossoplasty in a calf with bifid tongue. Acta Sci Vet, 47, 386.
  11. Lu CY, Teng RJ, Hou JW (1998): Bifid tongue associated with midline cleft palate, mandible, cervical vertebrae and linea alba. Eur J Pediatr, 157, 86.
  12. Martini-Santos BJ, Diefenbach A, Peixoto TC, et al (2012): Anomalias congênitas múltiplas em felinos domésticos neonatos. Acta Sci Vet, 40, 1087.
  13. Millard DR (1977): Mandibular clefts. In Cleft Craft: the Evolution of its Surgery. Bilateral and Rare Deformities. Boston, Little, Brown. pp. 809-816.
  14. Mills JL, Signore C (2004): Neural tube defect rates before and after food fortification with folic acid. Birth Defects Res A Clin Mol Terato, 70, 844–845.
  15. Moore KL, Persaud TVN, Torchia MG (2016): Klinik Yönleriyle İnsan Embriyolojisi. Nobel Tıp Kitabevleri, İstanbul.
  16. Nonata IA, Ferreira MR, Miranda JL, et al (2019): Cranioschisis and Anencephaly in a Dog - Challenging Etiology. Acta Sci Vet, 47, 449.
  17. Padmanabhan R (2006): Etiology, pathogenesis and prevention of neural tube defects. Congenit Anom, 46, 55-67.
  18. Rao S, Oak S, Wagh M, et al (1997) Congenital midline palatomandibular bony fusion with a mandibular cleft and bifid tongue. Br J Plast Surg, 50, 139-141.
  19. Rifai S, Bouayad H, Kay Get, al (2006): Bifid tongue and mandibular cleft in three mule foals. Vet Rec, 158, 97-98.
  20. Sadler TW (2017): Langman Medikal Embriyoloji. Palme Yayıncılık, Ankara.
  21. Safra N, Bassuk AG, Ferguson PJ, et al (2013): Genome-wide association mapping in dogs enables identification of the Homeobox gene, NKX2-8, as a genetic component of neural tube defects in humans. PLoS Genet, 9, e1003646.
  22. Santos Luz M, Bobany DM, Monteiro Silva ME, et al (2016): Anencephaly associated with cleft palate in a Bull Terrier litter: case report. IOSR J Agric Vet Sci, 9, 18-20.
  23. Thomas ZM, Podadera JM, Donahoe SL, et al (2020): Neural tube defects in four Shetland sheepdog puppies: clinical characterisation and computed tomography investigation. Aust Vet J, 98, 312-318.
  24. Villagomez DAF, Alonso RA (1998): A distinct Mendelian autosomal recessive syndrome involving the association of anotia, palate agenesis, bifid tongue, and polydactyly in the dog. Can Vet J, 39, 642-643.
  25. Yin S, Zhao Z (2020): Incomplete cleft palate, Bifid Tongue, and Oral Hamartomas: A rare congenital anomaly. J Craniofac Surg, 31, 184-185.