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Journals / Afyon Kocatepe Üniversitesi Fen ve Mühendislik Bilimleri Dergisi / 2026 / Cilt: 23 Sayı: 2

Investigation and Quantification of Electrochemical Properties of the Anti-Cancer Drug Vinblastine on the Pencil Graphite Electrode Surface

Anti-Kanser İlaç Vinblastin’in Kalem Grafit Elektrot Yüzeyinde Elektrokimyasal Özelliklerinin İncelenmesi Ve Miktar Tayini

Günay Önal(BATMAN ÜNİVERSİTESİ)0000-0001-7595-9417
Pages
344–354
Publication Date
2023-05-03
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The analytical application of the proposed method has been practiced in drug and urine samples and demonstrated with recoveries.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Vinblastine (VNB) is an antineoplastic drug used in cancer chemotherapy.
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Key Findings & Data:In this presented study, the electrochemical properties of VNB were investigated in a wide pH range with disposable pencil graphite (PG) electrode and different supporting electrolytes "Britton–Robinson (0.04 M BR, pH 2.0-12.0), phosphate (0.04 M PBS, pH)". 2.0, 3.0, 4.0, 7.4) and acetate (0.04 M ABS, pH 4.8) were studied by cyclic voltammetry "CV" and Square Wave Voltammetry "SWV" techniques.
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Conclusion & Impact:The analytical application of the proposed method has been practiced in drug and urine samples and demonstrated with recoveries.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Vinblastin · kalem grafit elektrot · voltametri

Abstract

Vinblastine (VNB) is an antineoplastic drug used in cancer chemotherapy. In this presented study, the electrochemical properties of VNB were investigated in a wide pH range with disposable pencil graphite (PG) electrode and different supporting electrolytes "Britton–Robinson (0.04 M BR, pH 2.0-12.0), phosphate (0.04 M PBS, pH)". 2.0, 3.0, 4.0, 7.4) and acetate (0.04 M ABS, pH 4.8) were studied by cyclic voltammetry "CV" and Square Wave Voltammetry "SWV" techniques. VNB gave an irreversible oxidation peak with CV in BR (pH 2.0) at +0.993 V potential and 3.844 µA current. With the SWV technique, the anodic current signal showed a linear correlation with the concentration between 11 nM and 495 nM in BR (pH 2.0) '' Ip (µA) = 0.0087 C (nM) - 0.3448 (r = 0.993, n = 12) '' . At a concentration level of 11 nM, a limit of detection (LOD) of 2.4 nM and a relative standard deviation of 2.93% were calculated. The analytical application of the proposed method has been practiced in drug and urine samples and demonstrated with recoveries.

Özet

Kanser kemoterapisinde kullanılan vinblastin (VNB) antineoplastik bir ilaçtır. Sunulan bu çalışmada, VNB‘nin elektrokimyasal özellikleri tek kullanımlık kalem grafit (PG) elektrot ile geniş bir pH aralığında ve farklı destek elektrolitler ‘’Britton–Robinson (0.04 M BR, pH 2.0-12.0), fosfat (0.04 M PBS, pH 2.0, 3.0, 4.0, 7.4) ve asetat ( 0.04 M ABS, pH 4.8) içinde döngüsel voltametri ‘’CV’’ ve Kare Dalga Voltametri ‘’SWV’’ teknikleriyle incelenmiştir. VNB, +0.993 V gerilim ve 3.844 µA akım değerinde BR (pH 2.0) içinde CV ile tersinmez bir yükseltgenme piki vermiştir. SWV tekniği ile anodik akım sinyali, BR (pH 2.0) içerisinde 11 nM ile 495 nM arasında derişim ile doğrusal bir korelasyon gösterdi ‘’Ip (µA) = 0.0087 C (nM) - 0.3448 (r = 0.993, n = 12)’’ . 11 nM derişim seviyesinde, 2.4 nM gözlenebilme sınırı (LOD) ve % 2.93 göreli standart sapma hesaplandı. Önerilen yöntemin analitik uygulaması ilaç ve idrar örneklerinde pratik edilmiş ve geri kazanımlarla gösterilmiştir.

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Cite This Article

Önal, G. (2023). Investigation and Quantification of Electrochemical Properties of the Anti-Cancer Drug Vinblastine on the Pencil Graphite Electrode Surface. Afyon Kocatepe Üniversitesi Fen ve Mühendislik Bilimleri Dergisi, Cilt: 23 Sayı: 2, 344–354. https://doi.org/10.35414/akufemubid.1173208

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