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Journals / Adıyaman Üniversitesi Fen Bilimleri Dergisi / 2020 / Cilt: 10 Sayı: 2

Synthesis and Anticancer Activities of Water Soluble Schiff Base Metal Complexes

Suda Çözünebilir Schiff Bazı Metal Komplekslerinin Sentezi ve Antikanser Aktivitesi

Burcu Saygıdeğer Demir(CUKUROVA UNIVERSITY)0000-0001-5179-0522
İlyas Gönül(CUKUROVA UNIVERSITY)0000-0002-7697-3613
Gizem Gümüşgöz Çelik(GEBZE TECHNICAL UNIVERSITY)0000-0003-4816-7419
Seda İpekbayrak(CUKUROVA UNIVERSITY)0000-0001-7628-807X
Yasemin Saygideger(CUKUROVA UNIVERSITY)0000-0003-3293-373X
Pages
441–454
Publication Date
2020-12-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These last two complexes also induced apoptosis and suppressed cell migration on A549 cells.

📌 3 Key Takeaways

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Objective & Hypothesis:In this study, we synthesized the water-soluble Schiff Base containing S, O, N heteroatoms by the condensation reaction from 4-amino-3-hydroxynaphthalene-1-sulfonic acid and 2- hydroxy-3-methoxybenzaldehyde.
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Key Findings & Data:The anticancer activities of ligand and its three metal complexes on A549 lung cancer cell lines were evaluated.
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Conclusion & Impact:These last two complexes also induced apoptosis and suppressed cell migration on A549 cells.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Schiff bazı · Metal kompleksleri · Akciğer kanseri

Abstract

In this study, we synthesized the water-soluble Schiff Base containing S, O, N heteroatoms by the condensation reaction from 4-amino-3-hydroxynaphthalene-1-sulfonic acid and 2- hydroxy-3-methoxybenzaldehyde. In addition, Cu (II), Zn (II) and Ni (II) complexes of the ligand were synthesized and characterized by elemental analysis, magnetic susceptibility and spectroscopic techniques such as FT-IR, H-NMR and C-NMR. The anticancer activities of ligand and its three metal complexes on A549 lung cancer cell lines were evaluated. Cell viability experiments revealed that Ligand (L) and nickel (II) complex (L-Ni) did not able to inhibit A549 cell proliferation while L-Cu and L-Zn had 12 and 80 μM of IC50 values respectively. These last two complexes also induced apoptosis and suppressed cell migration on A549 cells.

Özet

Bu çalışmada, 4-amino-3-hidroksinaftalin-1-sülfonik asit ve 2-hidroksi-3- metoksibenzaldehitten kondensasyon reaksiyonu ile S, O, N hetero atomları içeren suda çözünebilir bir Schiff Bazı elde edildi. Ek olarak, ligandın Cu (II), Zn (II) ve Ni (II) kompleksleri sentezlendi ve elementel analiz, manyetik duyarlılık ve FT-IR, H-NMR ve C-NMR gibi spektroskopik tekniklerle karakterize edildi. Ligandın ve üç metal kompleksinin A549 akciğer kanseri hücre hattında antikanser aktiviteleri değerlendirildi. L-Cu ve L-Zn olarak etiketlenmiş Bakır (II) ve Çinko (II) komplekslerinin IC50 değerleri sırasıyla 12 ve 80 μM olarak bulundu. L- Cu ve L-Zn komplekslerinin A549 hücrelerinde apoptozu indüklediği ve hücre göçünü inhibe ettiği görüldü. Ligand (L) ve Nikel (II) bileşiklerinin (L-Ni) A549 hücre proliferasyonu üzerinde herhangi bir etki göstermediği belirlendi.

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Cite This Article

Demir, B. S., Gönül, İ., Çelik, G. G., İpekbayrak, S., Saygideger, Y. (2020). Synthesis and Anticancer Activities of Water Soluble Schiff Base Metal Complexes. Adıyaman Üniversitesi Fen Bilimleri Dergisi, Cilt: 10 Sayı: 2, 441–454. https://doi.org/10.37094/adyujsci.738743

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