In this review, the effect of miRNAs from epigenetic mechanisms in the pathogenesis of cancer is discussed.
📌 3 Key Takeaways
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Objective & Hypothesis:microRNAs (miRNA) are small and short, non-coding RNAs that regulate gene expression in plants, animals and some viruses. miRNAs can bind to target messenger RNA (mRNA) transcripts of protein-coding genes and negatively control their translation or cause mRNA degradation. miRNAs such as apoptosis, differentiation of stem cells, cell cycle regulation and the pathogenesis of cancer may act in many biological processes. miRNAs associated with process of carcinogenesis may function tumor suppressor or oncogenic, according to their mRNA targets.
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Key Findings & Data:microRNAs (miRNA) are small and short, non-coding RNAs that regulate gene expression in plants, animals and some viruses. miRNAs can bind to target messenger RNA (mRNA) transcripts of protein-coding genes and negatively control their translation or cause mRNA degradation. miRNAs such as apoptosis, differentiation of stem cells, cell cycle regulation and the pathogenesis of cancer may act in many biological processes. miRNAs associated with process of carcinogenesis may function tumor suppressor or oncogenic, according to their mRNA targets.
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Conclusion & Impact:In this review, the effect of miRNAs from epigenetic mechanisms in the pathogenesis of cancer is discussed.
microRNAs (miRNA) are small and short, non-coding RNAs that regulate gene expression in plants, animals and some viruses. miRNAs can bind to target messenger RNA (mRNA) transcripts of protein-coding genes and negatively control their translation or cause mRNA degradation. miRNAs such as apoptosis, differentiation of stem cells, cell cycle regulation and the pathogenesis of cancer may act in many biological processes. miRNAs associated with process of carcinogenesis may function tumor suppressor or oncogenic, according to their mRNA targets. In this review, the effect of miRNAs from epigenetic mechanisms in the pathogenesis of cancer is discussed.
Özet
mikroRNAlar (miRNA) bitkiler, hayvanlar ve bazı virüslerde gen ifadesini düzenleyen, protein kodlamayan küçük ve kısa RNAlardır. miRNAlar, protein kodlayan genlerin transkriptleri olan hedef mRNAlara bağlanabilirler ve translasyonu negatif olarak regüle edebildikleri gibi, mRNAları degradasyona uğratarak da işlev gösterebilirler. miRNAlar apoptoz, kök hücrelerin farklılaşması, hücre siklusunun regü-lasyonu ve kanser patogenezi gibi birçok biolojik süreçte işlev gösterebilmektedirler. Karsinogenez süreci ile ilişkili miRNAlar hedef aldık-ları mRNAlara göre tümör baskılayıcı veya onkojenik özellik gösterebilirler. Bu derlemede kanserin patogenezinde epigenetik mekanizma-lardan miRNAların etkisi tartışılmıştır.
BAĞCI, Ö. (2014). microRNAs (miRNA) and Cancer. Uludağ Üniversitesi Tıp Fakültesi Dergisi, Cilt: 40 - Sayı: 2, 105–109. https://ajindex.com/articles/134995