Journals / Uludağ Üniversitesi Tıp Fakültesi Dergisi / 2018 / Cilt: 44 - Sayı: 2

DOSIMETRIC COMPARISON OF SCALP AND ORGANS AT RISK WITH DIFFERENT RADIOTHERAPY TECHNIQUES IN MALIGN GLIAL TUMORS

Malign Glial Tümörlerde Farklı Radyoterapi Teknikleri ile Saçlı Deri ve Riskli Organların Dozimetrik Karşılaştırılması

Pages
95–101
Publication Date
2018-08-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It has been shown by this study, the inclusion of scalp into the treatment plan does not have a negative effect on the target volume doses, and our patients may be protected from cosmetic and psychosocial side effects caused by permanent hair loss.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In malign glial tumors treated with radiotherapy (RT); despite the current treatment plan with volumetric arc (t-VMAT) technique, 1 arc VMAT and static 5 field intensity modulated RT technique wre compered dosimetrically.
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Key Findings & Data:Sixteen malign glial tumors treated with at least 50 Gy RT were included.
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Conclusion & Impact:It has been shown by this study, the inclusion of scalp into the treatment plan does not have a negative effect on the target volume doses, and our patients may be protected from cosmetic and psychosocial side effects caused by permanent hair loss.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:malign glial tümör · radyoterapi tekniği · saçlı deri

Abstract

In malign glial tumors treated with radiotherapy (RT); despite the current treatment plan with volumetric arc (t-VMAT) technique, 1 arc VMAT and static 5 field intensity modulated RT technique wre compered dosimetrically. Sixteen malign glial tumors treated with at least 50 Gy RT were included. Sixteen, 30 and 24 Gray thresholds doses were used for mean, 1 and 9 cc scalp volumes. There was no statistically significant difference between methods in terms of planning treatment volume and risky organ doses. Significant reductions in scalp doses were observed (p < 0.05) with the inclusion of scalp regardless of the planning methods. Despite the hair loss in acute period, there was no permanent hair loss in any case in 12-month follow-up. It has been shown by this study, the inclusion of scalp into the treatment plan does not have a negative effect on the target volume doses, and our patients may be protected from cosmetic and psychosocial side effects caused by permanent hair loss.

Özet

Volumetrik ark (t-VMAT) tekniği ile radyoterapi (RT) uygulanan malign glial tümörlü hastalarda mevcut tedavi planına karşın 1 ark VMAT ve statik 5 alan yoğunluk ayarlı RT tekniği dozimetrik olarak karşılaştırıldı. Çalışmaya en az 50 Gy RT alan 18 malign glial tümörlü olgu dahil edildi. Saçlı deri ortalama, 1 ve 9 cc dozları için 16, 30 ve 24 Gray eşik değerleri kullanıldı. Yöntemler arasında planlama tedavi volümü ve riskli organ dozları açısından anlamlı fark bulunamadı. Planlamanın hangi yöntem ile yapıldığı önemli olmaksızın saçlı derinin planlamaya dahil edilmesiyle birlikte saçlı deri dozlarının anlamlı azaldığı görüldü (p < 0.05). Oniki aylık izlem süresi içinde akut dönemde saç kaybı yaşamalarına rağmen hiçbir olguda kalıcı saç kaybı görülmedi. Bu çalışma ile saçlı derinin tedavi planına dahil edilmesinin hedef volüm dozları açısından olumsuz etkisi olmadığı gibi hastalarımızın kalıcı saç dökülmesinin yaratacağı kozmetik ve psikososyal yan etkilerden korunabileceği ortaya konulmuştur.

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Cite This Article

AYDIN, O., SARIHAN, S., BOLAT, D., ALTAŞ, H., TUNÇ, S. G., KIRAY, Z. (2018). DOSIMETRIC COMPARISON OF SCALP AND ORGANS AT RISK WITH DIFFERENT RADIOTHERAPY TECHNIQUES IN MALIGN GLIAL TUMORS. Uludağ Üniversitesi Tıp Fakültesi Dergisi, Cilt: 44 - Sayı: 2, 95–101. https://ajindex.com/articles/134886

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References (12)

  1. Gondi V, Vogelbaum MA, Grimm S, Mehta MP (eds). Primary intracranial neoplasms. In: Halperin EC, Wazer DE, Perez CA, Brady LW, eds. Principles and Practice of Radiation Oncology, 6th ed. Philadelphia, LWW, 2013; 938-973
  2. Stupp R, Brada M, Van Den Bent, Tonn JC, Penthheroudakis G, ESMO Guidelines Working Group. High-grade Glioma: Esmo Clinical Practice Guidelines For Diagnosis, Treatment And Follow-Up. Ann Oncol, 2014, 25, Suppl 3
  3. Gzell C, Back M, Wheeler H, Bailey D, Foote M. Radiotherapy in Glioblastoma: The Past, The Present And The Future. Clin Oncol, 2017, 29 (1): 15-25
  4. Gondi V, Pugh SL, Tome WA, et al. Preservation of memory with conformal compartmnt during whole-brain radiotherapy for brain metastases (RTOG 0933): a phase II multi-institutional trial. J Clin Oncol, 32 (34): 3810-6
  5. Lawenda BD, Gagne HM, Gierga DP, et al. Permanent alopecia after cranial irradiation: dose-response relationship. Int J Radiat Oncol Biol Phys. 2004, 60 (3): 879-87
  6. Severs GA, Griffin T, Werner-Wasik M. Cicatricial alopecia secondary to radiation therapy: case report and review of the literatüre. Cutis 2008, 81 (2): 147-53
  7. Roberge D, Parker W, Niazi TM, Olivares M. Treating the contents and not the container: dosimetric study of hair-sparing whole brain intensity modulated radiation therapy. Technol Cancer Res Treat, 2005, 4 (5): 567-70
  8. Mancini BR, Kim LH, Shaitelman SF, et al. Intensity modulated or volumetric modulated radiation therapy (IMRT or VMAT) to reduce alopecia, xerostomia, and otitis after whole brain radiation therapy for brain metastases: a planning analysis. Int J Radiat Oncol Biol Phys. 2010, 78 (3), suppl, abstract no 3422, page S840
  9. Mahadevan A, Sampson C, LaRosa S, et al. Dosimetric Analysis Of The Alopecia Preventing Effect Of Hippocampus Sparing Whole Brain Radiation Therapy. Radiat Oncol, 2015, 10: 245
  10. Kao J, Darakchiev B, Conboy L, et al. Tumor Directed, Scalp Sparing Intensity Modulated Whole Brain Radiotherapy For Brain Metastases. Technol Cancer Res Treat, 2015, 14 (5): 547-555
  11. Schiopu SR, Habl G, Hafner M, et al. Craniospinal irradiation using helical tomotherapy for central nervous system tumors. J Radiat Res, 2017, 58 (2): 238-246
  12. Sood S, Pokhrel D, McClinton C, et al. Volumetric-modulated arc therapy (VMAT) for whole brain radiotherapy: not only for hippocampal sparing, but also for reduction of dose to organs at risk. Med Dosim, 2017, 42 (4): 375-383. 13. https://ctep.cancer.gov 14. https://www.