Journals / Uludağ Üniversitesi Tıp Fakültesi Dergisi / 2013 / Cilt: 39 - Sayı: 1

The Role of H-FABP at Emergency Department for Early Detection of Cardiac Damage in Carbon Monoxide Poisoning

Karbon Monoksit Zehirlenmesinde Kalp Tipi Yağ Asit Bağlayıcı Protein'in (H-Fabp) Kardiyak Hasarı Erken Tanımadaki Yeri

Pages
15–18
Publication Date
2013-03-01
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this study, sufficient data were not obtained to conclude that whether or not H-FABP provides an advantage in early period for diagnosing cardiac damage resulted from CO poisoning.

📌 3 Key Takeaways

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Objective & Hypothesis:Carbon monoxide (CO) poisoning leads to cardiac damage by causing tissue hypoxia.
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Key Findings & Data:Carboxi-hemoglobin (COHb) levels, electrocardiographic (ECG) changes, creatinine kinase, creatinine kinase myoglobin, troponin I and H-FABP levels were investigated in blood gas of 60 patients admitted to Emergency Department and diagnosed as having CO poisoning.
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Conclusion & Impact:In this study, sufficient data were not obtained to conclude that whether or not H-FABP provides an advantage in early period for diagnosing cardiac damage resulted from CO poisoning.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Karbon monoksit zehirlenmesi. H-FABP. Kardiyak hasar · Carbon monoxide poisoning. H-FABP. Cardiac damage

Abstract

Carbon monoxide (CO) poisoning leads to cardiac damage by causing tissue hypoxia. Some electrocardiographic changes and biochemical indicators were reported in cardiac damage occurring due to CO poisoning. In this study, it is aimed to reveal whether or not Human Fatty Acid Binding Protein (H-FABP) provides an advantage for diagnosing cardiac damage depending on CO poisoning in early phase. Carboxi-hemoglobin (COHb) levels, electrocardiographic (ECG) changes, creatinine kinase, creatinine kinase myoglobin, troponin I and H-FABP levels were investigated in blood gas of 60 patients admitted to Emergency Department and diagnosed as having CO poisoning. Median COHb levels of the patients were determined as 21.8 ( min-max=7.3-42.7). Negative T wave in ECG of 24 patients and ST segment eleva-tion in ECG of 1 patient were detected. Cardiac biochemical indicators and H-FABP levels of the patient with ST segment elevation were positive. In this study, sufficient data were not obtained to conclude that whether or not H-FABP provides an advantage in early period for diagnosing cardiac damage resulted from CO poisoning.

Özet

Karbon monoksit (CO) zehirlenmesi yaygın doku hipoksisi oluşturarak kardiyak hasara neden olur. Karbon monoksit zehirlenmesine bağlı oluşan kardiyak hasarda biyokimyasal belirteçler ve elektrokardiyografik değişiklikler bildirilmiştir. Bu çalışmada CO zehirlenmesine bağlı kardiyak hasarın gösterilmesinde erken dönemde insan yağ asit bağlayıcı proteinin (H-FABP) avantaj sağlayıp sağlamadığını göstermeyi amaçladık. Hastanemiz acil servisine başvuran ve CO zehirlenmesi tanısı alan 60 hastanın kan gazında karboksihemoglobin (COHb) düzey-leri, elektrokardiyografi (EKG) değişiklikleri, kreatinin kinaz, kreatinin kinaz miyoglobin, troponin I ve H-FABP düzeyleri incelenmiştir. Hastaların medyan COHb düzeyleri 21.8 (min-maks=7.3-42.7) olarak tespit edildi. 24 hastanın EKG'sinde T negatifliği ve bir hastanın EKG'sinde ST segment elevasyonu tespit edildi. ST segment elevasyonu olan hastanın kardiyak biyokimyasal belirteçleri ve H-FABP düzey-leri pozitif tespit edildi. Bu çalışmada ise CO zehirlenmesine bağlı kardiyak hasarın erken dönemde tespit edilmesinde H-FABP'nin avantaj sağlayıp sağlamadığını gösteren yeterli veriye ulaşılamamıştır.

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Cite This Article

AHUN, E., KÖKSAL, Ö., ARMAĞAN, E., YILDIRIM, H., ÖZDEMİR, F., AYDIN, Ş., KÖSE, A., DURAK, V. A., SIĞIRLI, D. (2013). The Role of H-FABP at Emergency Department for Early Detection of Cardiac Damage in Carbon Monoxide Poisoning. Uludağ Üniversitesi Tıp Fakültesi Dergisi, Cilt: 39 - Sayı: 1, 15–18. https://ajindex.com/articles/134789

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