SavedAdd your journal

Journals / Uludağ Üniversitesi Tıp Fakültesi Dergisi / 2020 / Cilt: 46 - Sayı: 2

Drosophila melanogaster Model in Neurodegenerative Disease Research

Nörodejeneratif Hastalık Araştırmalarında Drosophila melanogaster Modeli

Cem HAZIR
Gamze BORA
Hayat ERDEM YURTER
Pages
237–245
Publication Date
2020-08-01
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this review, advantages of D. melanogaster as a model organism and its use in neurodegenerative diseases are discussed.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Modelling human diseases in Drosophila melanogaster have been accelerated advances in many areas including investigations on pathophysiology, identification of new genes and genetic modifiers, explanations of clinic variability, development of new diagnosis and treatment approaches and drug investigations.
📊
Key Findings & Data:In this review, advantages of D. melanogaster as a model organism and its use in neurodegenerative diseases are discussed.Modelling human diseases in Drosophila melanogaster have been accelerated advances in many areas including investigations on pathophysiology, identification of new genes and genetic modifiers, explanations of clinic variability, development of new diagnosis and treatment approaches and drug investigations.
💡
Conclusion & Impact:In this review, advantages of D. melanogaster as a model organism and its use in neurodegenerative diseases are discussed.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Drosophila melanogaster · model organizma · nörodejeneratif hastalık

Abstract

Modelling human diseases in Drosophila melanogaster have been accelerated advances in many areas including investigations on pathophysiology, identification of new genes and genetic modifiers, explanations of clinic variability, development of new diagnosis and treatment approaches and drug investigations. In this review, advantages of D. melanogaster as a model organism and its use in neurodegenerative diseases are discussed.Modelling human diseases in Drosophila melanogaster have been accelerated advances in many areas including investigations on pathophysiology, identification of new genes and genetic modifiers, explanations of clinic variability, development of new diagnosis and treatment approaches and drug investigations. In this review, advantages of D. melanogaster as a model organism and its use in neurodegenerative diseases are discussed.

Özet

İnsan hastalıklarının Drosophila melanogaster’de modellenmesi sayesinde, patofizyolojilerin araştırılması, yeni genlerin ve genetik düzenleyicilerin tanımlanması, klinik çeşitlilik nedenlerinin açıklanabilmesi, yeni tanı ve tedavi yaklaşımlarının geliştirilmesi, ilaç araştırma çalışmalarının yapılabilmesi gibi birçok alandaki gelişmeler hız kazanmıştır. Bu derlemede D. melaonogaster’in model organizma olarak avantajları ve nörodejeneratif hastalıklarla ilişkili araştırmalarda kullanılmasına ilişkin bilgiler verilmektedir.

🔖

Cite This Article

HAZIR, C., BORA, G., YURTER, H. E. (2020). Drosophila melanogaster Model in Neurodegenerative Disease Research. Uludağ Üniversitesi Tıp Fakültesi Dergisi, Cilt: 46 - Sayı: 2, 237–245. https://ajindex.com/articles/134784

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (19)

  1. Jenning BH. Drosophila – a versatile model in biology and medicine. Materials Today. 2011;14:190-195
  2. The Nobel Price in Physiology or Medicine (1933).
  3. Tolwinski NS. Introduction: Drosophila- a model system for developmental biology. J Dev Biol. 2017;5:9
  4. Allocca M, Zola S, Bellosta P. The fruit fly, Drosophila melanogaster: the making of a model (Part I). In: Perveen FK, (eds). Drosophila melanogaster: Model for Recent Advances in Genetics and Therapeutics. Rijeka, Croatia: InTech;2018:113-130
  5. Ankeny RA, Leonelli S. What’s so special about model organisms. Studies in History and Philosophy of Science. 2011;42:314-323
  6. Hedges SB. The origin and evolution of model organisms. Nature. 2002;3:838-849
  7. Bachli G. TaxoDros: The database on taxonomy of Drosophilidae, (taxodros.uzh.cs). (1999-2006)
  8. Gonzalez C. Drosophila melanogaster: a model and tool to investigate malignancy and identify new therapeutics. Nature Rev. 2013;13:172-183
  9. McGurk L, Berson A, Bonini NM. Drosophila as in vivo model for human neurodegenerative disease. Genetics. 2015;201:377-402
  10. Sang TK, Jackson RG. Drosophila models of neurodegenerative disease. The Journal of the American Society for Experimental NeuroTherapeutics. 2005;2:438-446
  11. Pandey UB, Nichols CD. Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery. Pharmacol Rev. 2011;63:412-431
  12. Baenas N, Wagner AE. Drosophila melanogaster as an alternative model organism in nutrigenomics. Genes Nutr. 2019;14:1-11
  13. Moreno MA, Farr CL, Kaguni LS, Garesse R. Drosophila melanogaster as a model system to study mitochondrial biology. Methods Mol Biol. 2007;372:33-49
  14. Flatt T. Life history evolution and the genetics of fitness components in Drosophila melanogaster. Genetics. 2020:214:3-48
  15. He Y, Jasper H. Studying aging in Drosophila. Methods. 2014;68:129–133
  16. Ryvkin J, Bentzur A, Krispil SZ, Ophir GS. Mechanisms underlying the risk to develop drug addiction, insights from studies in Drosophila melanogaster. Front Physiol. 2018;9:1-12
  17. Yamaguchi M, (eds). Drosophila models for human diseases. 1st edition. Singapore: Springer; 2018
  18. Potter CJ, Turenchalk GS, Xu T. Drosophila in cancer research an expanding role. Trends in Genetics. 2000;16:33-39
  19. Villegas SN. One hundred years of Drosophila cancer research: no longer in solidute. Disease Models and Mechanisms. 2019;12:1-5. 20.