Journals / Uludağ Üniversitesi Tıp Fakültesi Dergisi / 2016 / Cilt: 42 - Sayı: 1

The Association Between Disease Scores and N Terminal Brain Natriuretic Peptide Levels in The Patients With Liver Cirrhosis

Karaciğer Sirozlu Hastalarda N-Terminal Beyin Natriüretik Peptid Seviyeleri ile Hastalık Göstergeleri Arasındaki İlişki

Pages
9–11
Publication Date
2016-03-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

NT pro-BNP increases with the severity of liver disorder in the patients with chronic liver disease who do not have cardiac failure and it can be accepted as an inexpensive, non-invasive serological marker providing rapid results which can be used as a predictor for mortality.

📌 3 Key Takeaways

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Objective & Hypothesis:Brain Natriuretic Peptide (BNP) and pro-Brain Natriuretic Peptide (pro-BNP) levels have diagnostic value for congestive cardiac failure.
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Key Findings & Data:In this study, it was aimed to assess whether N terminal Brain Natriuretic Peptide (NT pro-BNP) level increases as severity of underlying liver disease, Child-Pugh and model for end-stage liver disease (MELD) scores worsen, to disclose the association between the severity of liver disease and the levels of NT pro-BNP.
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Conclusion & Impact:NT pro-BNP increases with the severity of liver disorder in the patients with chronic liver disease who do not have cardiac failure and it can be accepted as an inexpensive, non-invasive serological marker providing rapid results which can be used as a predictor for mortality.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Beyin NatriüretikPeptidi. Karaciğer sirozu. Child-Pugh · Brain natriuretic peptide. Liver cirrhosis. Child-Pugh

Abstract

Brain Natriuretic Peptide (BNP) and pro-Brain Natriuretic Peptide (pro-BNP) levels have diagnostic value for congestive cardiac failure. In this study, it was aimed to assess whether N terminal Brain Natriuretic Peptide (NT pro-BNP) level increases as severity of underlying liver disease, Child-Pugh and model for end-stage liver disease (MELD) scores worsen, to disclose the association between the severity of liver disease and the levels of NT pro-BNP. There was a significant difference when NT pro-BNP levels were evaluated by Child-Pugh and MELD score (p<0,05). A significant difference was found when controls and group of the patients were compared with regard to pro-BNP levels (p<0.05). NT pro-BNP increases with the severity of liver disorder in the patients with chronic liver disease who do not have cardiac failure and it can be accepted as an inexpensive, non-invasive serological marker providing rapid results which can be used as a predictor for mortality.

Özet

Beyin NatriüretikPeptidi (BNP) ve pro-Beyin NatriüretikPeptidi (pro-BNP) düzeyleri konjestif kalp yetersizliğinde tanısal değere sahiptir. Bu çalışmada, karaciğer hastalıklarının şiddeti ile N terminal Beyin Natriüretik Peptidi (NT pro-BNP) seviyeleri arasındaki ilişkinin ortaya konması için, karaciğer sirozu tanılı hastalarda altta yatan karaciğer hastalığının ciddiyeti, Child-Pugh ve Model forend-stageliverdisease (MELD) skorunda artış olmasıyla birlikte NT pro-BNP düzeyinde yükselme olup olmadığının değerlendirilmesi amaçlanmıştır. Hasta grubunda Child-Pugh ve MELD skoruna göre NT pro-BNP düzeyleri değerlendirildiğinde anlamlı fark vardı (p<0,05). Pro-BNP seviyeleri açısından hasta ile kontrol grubu karşılaştırıldığında arada anlamlı farklılık saptandı (p<0,05). NT pro–BNP kalp yetmezliği olmayan kronik karaciğer hastalığı olan kişilerde karaciğer hastalığının şiddeti ile artmaktadır ve mortalitenin ön belirleyicisi olarak kullanılabilecek ucuz, noninvaziv ve çabuk sonuç alınabilecek serolojik bir belirteç olarakdeğerlendirilebilir

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Cite This Article

VEYSELOĞLU, L., PEKGÖZ, M., GÜREL, S. (2016). The Association Between Disease Scores and N Terminal Brain Natriuretic Peptide Levels in The Patients With Liver Cirrhosis. Uludağ Üniversitesi Tıp Fakültesi Dergisi, Cilt: 42 - Sayı: 1, 9–11. https://ajindex.com/articles/134692

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