Journals / The Turkish Journal of Ear Nose and Throat / 2026 / Volume: 26 Issue: 4

Nasal type natural killer/T cell lymphoma: case series and literature review

Nazal tip doğal katil/T hücreli lenfoma: Olgu serisi ve literatür derlemesi

Mehmet Düzlü(Gazi Üniversitesi Tıp Fakültesi Kulak Burun Boğaz Anabilim Dalı, Ankara, Türkiye)
Ayça Ant(Dr. Abdurrahman Yurtaslan Ankara Onkoloji Eğitim ve Araştırma Hastanesi Kulak Burun Boğaz Kliniği, Ankara, Türkiye)
Hakan Tutar(Gazi Üniversitesi Tıp Fakültesi Kulak Burun Boğaz Anabilim Dalı, Ankara, Türkiye)
Recep Karamert(Gazi Üniversitesi Tıp Fakültesi Kulak Burun Boğaz Anabilim Dalı, Ankara, Türkiye)
Melih Şahin(Gazi Üniversitesi Tıp Fakültesi Kulak Burun Boğaz Anabilim Dalı, Ankara, Türkiye)
Erolcan Sayar(Gazi Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı, Ankara, Türkiye)
Nesibe Cesur(Yenimahalle Eğitim ve Araştırma Hastanesi Patoloji Labaratuvarı, Ankara, Türkiye)
Pages
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Publication Date
2016-09-10
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this article, we report four cases of nasal natural killer/T-cell lymphoma who were followed-up in our clinic and discuss the diagnosis and treatment of the disease in light of the literature data.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Nasal type natural killer/T-cell lymphoma is a rare type of extranodal non-Hodgkin lymphoma which originates from nasal cavity and paranasal sinuses.
📊
Key Findings & Data:Exact diagnosis of nasal natural killer/T-cell lymphoma, which is a rapidly progressive clinical condition, may be established by immunohistochemical analysis on biopsy material after clinical suspicion.
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Conclusion & Impact:In this article, we report four cases of nasal natural killer/T-cell lymphoma who were followed-up in our clinic and discuss the diagnosis and treatment of the disease in light of the literature data.
🔬Design:Article
📍Scope:Comprehensive Sample
⚙️Variables:Chemotherapy · nasal cavity · natural killer/T cell lymphoma

Abstract

Nasal type natural killer/T-cell lymphoma is a rare type of extranodal non-Hodgkin lymphoma which originates from nasal cavity and paranasal sinuses. Exact diagnosis of nasal natural killer/T-cell lymphoma, which is a rapidly progressive clinical condition, may be established by immunohistochemical analysis on biopsy material after clinical suspicion. In this article, we report four cases of nasal natural killer/T-cell lymphoma who were followed-up in our clinic and discuss the diagnosis and treatment of the disease in light of the literature data.

Özet

Nazal tip doğal katil/T hücreli lenfoma nazal kavite ve paranazal sinüslerden kaynaklanan, nadir görülen bir ekstranodal non-Hodgkin lenfoma türüdür. Hızlı ilerleyen bir klinik durum olan nazal doğal katil/T hücreli lenfomanın kesin tanısı klinik şüphenin ardından biyopsi materyalinde immünohistokimyasal analiz yapılması sonucu konabilir. Bu yazıda, kliniğimizde takip edilen dört nazal doğal katil/T hücreli lenfoma olgusu bildirildi ve hastalığın tanı ve tedavisi literatür verileri ışığında tartışıldı

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Cite This Article

Düzlü, M., Ant, A., Tutar, H., Karamert, R., Şahin, M., Sayar, E., Cesur, N. (2016). Nasal type natural killer/T cell lymphoma: case series and literature review. The Turkish Journal of Ear Nose and Throat, Volume: 26 Issue: 4. https://ajindex.com/articles/1329426

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References (15)

  1. Jaffe ES, Harris NL, Stein H, Vardiman JW. Pathology and genetics of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press; 2001.
  2. Ooi GC, Chim CS, Liang R, Tsang KW, Kwong YL. Nasal T-cell/natural killer cell lymphoma: CT and MR imaging features of a new clinicopathologic entity. AJR Am J Roentgenol 2000;174:1141-5.
  3. Jaffe ES, Krenacs L, Kumar S, Kingma DW, Raffeld M. Extranodal peripheral T-cell and NK-cell neoplasms. Am J Clin Pathol 1999;111:46-55.
  4. Aozasa K, Zaki MA. Epidemiology and pathogenesis of nasal NK/T-cell lymphoma: a mini-review. ScientificWorldJournal 2011;11:422-8.
  5. Al-Hakeem DA, Fedele S, Carlos R, Porter S. Extranodal NK/T-cell lymphoma, nasal type. Oral Oncol 2007;43:4-14.
  6. Mestiri S, Zeglaoui I, Sriha B, Belcadhi M, Bouzouita K, Korbi S. Extra-nodal T lymphomas of the nasal cavities and sinuses. Ann Otolaryngol Chir Cervicofac 2008;125:188-92. [Abstract]
  7. Kato N, Yasukawa K, Onozuka T, Kikuta H. Nasal and nasal-type T/NK-cell lymphoma with cutaneous involvement. J Am Acad Dermatol 1999;40:850-6.
  8. Zhong BN, Zhang XH, Li M, Cao HG, Li N, Liu CY, et al. Study of the pathology, immunophenotype, etiology and genetic marker of NK/T-cell lymphoma. Zhonghua Xue Ye Xue Za Zhi 2003;24:505-9. [Abstract]
  9. Wu X, Li P, Zhao J, Yang X, Wang F, Yang YQ, et al. A clinical study of 115 patients with extranodal natural killer/T-cell lymphoma, nasal type. Clin Oncol (R Coll Radiol) 2008;20:619-25.
  10. Jaccard A, Hermine O. Extranodal natural killer/T-cell lymphoma: advances in the management. Curr Opin Oncol 2011;23:429-35.
  11. Cleary KR, Batsakis JG. Sinonasal lymphomas. Ann Otol Rhinol Laryngol 1994;103:911-4.
  12. Kubat G, Mülazimoğlu S, Kaygusuz G, Küçük B, Yorulmaz İ. İnvaziv fungal sinüzit ile karışan sinonazal ekstranodal NK/T hücreli lenfoma: Olgu sunumu. KBB-Forum 2013;13:98-103.
  13. Liang R. Advances in the management and monitoring of extranodal NK/T-cell lymphoma, nasal type. Br J Haematol 2009;147:13-21.
  14. Vose J, Armitage J, Weisenburger D. International peripheral T-cell and natural killer/T-cell lymphoma study: pathology findings and clinical outcomes. J Clin Oncol 2008;26:4124-30.
  15. Schmitz N, Trümper L, Ziepert M, Nickelsen M, HoAD, Metzner B, et al. Treatment and prognosis of mature T-cell and NK-cell lymphoma: an analysis of patients with T-cell lymphoma treated in studies of the German High-Grade Non-Hodgkin Lymphoma Study Group. Blood 2010;116:3418-25.