Journals / Turkish Journal of Family Medicine and Primary Care / 2026 / Cilt: 19 Sayı: 2

Observation of Frank’s Sign in a Patient Applied to The Smoking Cessation Clinic

Sigara Bırakma Polikliniğine Başvuran Hastada Frank İşareti Gözlemlenmesi

Aynur Yıldırım(Konya Beyhekim Eğitim ve Araştırma Hastanesi)0000-0002-4120-5585
Pages
242–244
Publication Date
2025-06-09
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This case report presents a 42-year-old female patient who visited the smoking cessation clinic, reporting the presence of Frank's sign in herself and her family.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Smoking increases the risk of cardiovascular diseases and atherosclerosis.
📊
Key Findings & Data:Frank's sign is a diagonal crease in the earlobe, strongly associated with coronary atherosclerosis.
💡
Conclusion & Impact:This case report presents a 42-year-old female patient who visited the smoking cessation clinic, reporting the presence of Frank's sign in herself and her family.
🔬Design:Olgu Sunumu
📍Scope:Comprehensive Sample
⚙️Variables:Frank işareti · sigara bırakma · kardiyovasküler hastalık

Abstract

Smoking increases the risk of cardiovascular diseases and atherosclerosis. Frank's sign is a diagonal crease in the earlobe, strongly associated with coronary atherosclerosis. Detection of Frank's sign can help take early precautions regarding cardiovascular diseases. This case report presents a 42-year-old female patient who visited the smoking cessation clinic, reporting the presence of Frank's sign in herself and her family.

Özet

Sigara kardiyovasküler hastalık ve ateroskleroz riskini artırır. Frank işareti kulakta çapraz deri kıvrımıdır. Koroner ateroskleroz ile güçlü bir şekilde ilişkilendirilmiştir. Frank işareti tespiti kardiyovasküler hastalıklar açısından erkenden önlem almamıza yardımcı olabilir. Bu olgu sunumunda sigara bıraktırma polikliniğine başvuran 42 yaş kadın hastanın kendisinde ve ailesinde frank işareti bulunma durumu bildirilmiştir.

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Cite This Article

Yıldırım, A. (2025). Observation of Frank’s Sign in a Patient Applied to The Smoking Cessation Clinic. Turkish Journal of Family Medicine and Primary Care, Cilt: 19 Sayı: 2, 242–244. https://doi.org/10.21763/tjfmpc.1607307

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References (17)

  1. World Health Organization (WHO). The top 10 causes of death [Internet]. 2018 [cited 2024 Nov 20]. https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death
  2. Türkiye Endokrinoloji ve Metabolizma Derneği – Obezite, Lipid Metabolizması, Hipertansiyon Çalışma Grubu. Dislipidemi tanı ve tedavi kılavuzu. 2021. Erişim Tarihi: 25.12.2024
  3. Yıldız Fındık Ü, Yıldızeli Topçu S, Üstündağ H ve ark. Cerrahi hastalarının hastanede sigara içme durumlarının belirlenmesi (*). İ.Ü.F.N. Hem. Derg. 2010;18(1):26–32.
  4. Frank ST. Aural sign of coronary-artery disease. N Eng J Med. 1973;289(6):327-28.
  5. Baboujian A, Bezwada P, Ayala-Rodriguez C. Diagonal earlobe crease, a marker of coronary artery disease: a case report on frank’s sign. Cureus. 2019;11(3):e4219.
  6. Griffing G. Frank’s sign. N Engl J Med. 2014;370(10).
  7. Stoyanov GS, Dzhenkov D, Petkova L, et al. The histological basis of frank’s sign. Head Neck Pathol. 2021 Jun 1;15(2):402–7.
  8. Abrahim M. Unified anatomical explanation of diagonal earlobe creases, preauricular creases, and paired creases of the helix. Cureus. 2022;14(8):e27929.
  9. Himmatrao Saluba B, Himmatraoc P, Pramodini Himmatrao B. A premonitory diagnostic sign of impeding ischemic heart disease. J Family Med Prim Care. 2018;7(6):1361–7.
  10. Fabijanic D, Culic V. Diagonal ear lobe crease and coronary artery disease. Am J Cardiol. 2012;110(9):1385–6.
  11. Johar N, Sunil MK, Taneja N, et al. Ear lobe crease: a marker of coronary heart disease. Medico-legal Update. 2021;21(3):35–8.
  12. Shmilovich H, Cheng VY, Rajani R, et al. Relation of diagonal ear lobe crease to the presence, extent, and severity of coronary artery disease determined by coronary computed tomography angiography. Am J Cardiol. 2012;109(9):1283–7.
  13. Bazoukis G, Papadatos SS, Varrias D, et al. The importance of inspection in clinical cardiology: frank’s sign. Clin Case Rep. 2022;10(7):e6150.
  14. Elawad OAMA, Albashir AAD. Frank’s sign: dermatological marker for coronary artery disease. Oxf Med Case Reports. 2021;9:omab089.
  15. Pacei F, Bersano A, Brigo F, et al. Diagonal earlobe crease (Frank’s sign) and increased risk of cerebrovascular diseases: review of the literature and implications for clinical practice. Neurol Sci. 2020;41(2):257–62.
  16. Liu Z, Qiu J, Xu J, et al. Ear crease features are associated with complexity of coronary lesions. Med Sci Monit. 2020;26:e923343-1–9.
  17. Christoffels VM, Pu WT. Developing insights into cardiac regeneration. Development. 2013;14(19):3933–7.